Ozempic drug supresses desire to smoke, drink and more?

Post by code_duck » Sat, May 20, 2023, 6:55 AM UTC

vore wrote: post #309

usernew wrote: post #299

Earlier quoted context omitted.

and... this person now takes these last-measure pills forever? or here in the real world, do they use the pills to lose weight, and then maintain that normal weight forever with... perhaps a diet trick that works? people who have to take last-measure medication usually don't stop eating when they are full. i know, it's weird to tell someone who doesn't stop eating when they're full, how to still maintain weight if th…

Obesity is often a chronic medical condition that’s not solely controllable by willpower. There is no difference between taking pills for treating obesity as a chronic condition vs any other chronic condition, like type 1 diabetes. Decades of treating obesity as a personal failing have resulted in worse and unsustainable health outcomes. And again, you are being far too presumptuous about OP’s interventions. And I ce…

Post by rblatz » Sat, May 20, 2023, 7:01 AM UTC

riceart wrote: post #271

justinclift wrote: post #206

Earlier quoted context omitted.

Out of curiosity, do you drink much water each day? I'm kind of wondering if the people having a bad result don't drink enough water each day to clear out their systems? Yeah, that's a simplistic take... but still, curiosity. :)

Has nothing to do with it. A1c measures the percentage of hemoglobin A1 in red blood cells bound to sugars (glycated hemoglobin). Since red blood cells normally circulate for months this gives a surrogate marker for average blood glucose levels over 3-6 months. Dehydration is not a confounder for an A1c test since the percentage is relative to the hemoglobin present. The primary confounder to A1c are blood disorders…

Post by Earw0rm » Sat, May 20, 2023, 7:03 AM UTC

yieldcrv wrote: post #211

ramraj07 wrote: post #196

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For a long time we have known the existence of a network of hormones controlling our apetite on the gut brain axis, with names like ghrelin, leptin, glp-1, orexin, somatostatin, list goes on [1]. Issue was the network was tres complicé and hard to perturb without getting the opposite effect than what we wanted. Finally with glp-1, sglt2 and pcsk9 inhibition we are starting to be able to correct in the right way. To a…

can we do this for working out and exercise? I’m lean but dont do that and can recognize the benefits. It would be cool if we could pharmacologically make that appealing too. What if we could just continually swap in states. Executive work mode, ah it feels so good to think and focus. Empath mode, ah it feels so good to build relationships. Brolic mode, ah it feels so good to think about working out, and actually wor…

Post by eshack94 » Sat, May 20, 2023, 7:09 AM UTC

rblatz wrote: post #304

jmpman wrote: post #151

I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself…

I started taking it in November and I’m down 30 pounds and my retina has detached 2x for no apparent reason since then. My drinking is unchanged, except I get full sooner and drink slower. Because of the discomfort.

Post by vore » Sat, May 20, 2023, 7:25 AM UTC

usernew wrote: post #331

vore wrote: post #309

Earlier quoted context omitted.

Obesity is often a chronic medical condition that’s not solely controllable by willpower. There is no difference between taking pills for treating obesity as a chronic condition vs any other chronic condition, like type 1 diabetes. Decades of treating obesity as a personal failing have resulted in worse and unsustainable health outcomes. And again, you are being far too presumptuous about OP’s interventions. And I ce…

>not solely controllable by willpower so, would you say a solution to the problem that lets you eat as much as you want, so you don't have to use your willpower, be an appropriate solution to suggest? There is a difference between taking last-resort medication for the rest of your life, and eating apples.

  Substantial weight loss is possible across a range of treatment modalities, but long-term sustenance of lost weight is much more challenging, and weight regain is typical1–3. In a meta-analysis of 29 long-term weight loss studies, more than half of the lost weight was regained within two years, and by five years more than 80% of lost weight was regained (Figure 1)4. Indeed, previous failed attempts at achieving durable weight loss may have contributed to the recent decrease in the percentage of people with obesity who are trying to lose weight5 and many now believe that weight loss is a futile endeavor6.