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Effect of LSD on reinforcement learning in humans (2022)

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Re: Effect of LSD on reinforcement learning in humans (2022)

#91

Earlier quoted context omitted.

75ug would definitely be 'noticeable' if you took it sublingual. But this was an IV so I wouldnt know how much dilution there would be before passing the blood brain barrier. My best guess is that it would lower effective dose and how strong thr initial onset was.

Almost all drugs show higher potency when administered intravenously...

No, IV 'only' has 100% bioavailability. This does not reflect potency.

Re: Effect of LSD on reinforcement learning in humans (2022)

#92
post #73
post #69

Earlier quoted context omitted.

I think most people get over-sold blotters. Every now and then there's a study checking how much LSD is actually on sold-as-200ug blotters, and it's typically 60-80. This also leads to heavy overdoses when getting your hands on actual 200ug blotters...

FWIW I once got super high from a bottler. So high that I suspected it was either over dosed or even not LSD. I sent a similar one for analysis. Turned out it was pure LSD and about 125mg as advertised.

125mg is quite strong indeed yes. (Sorry, could not resist) ;-)

Re: Effect of LSD on reinforcement learning in humans (2022)

#93

Earlier quoted context omitted.

Im guessing you aren't injecting it

Are you? Getting access to liquid LSD and the means to IM or IV it are certainly not typical, or anywhere near the prevalence of access to the oral form

I mean it's water soluble and you can get syringes and medicinal NaCl solution in a pharmacy just fine, so if you really want to go down that road it's no problem. Just begs the question why anyone would do that.

Re: Effect of LSD on reinforcement learning in humans (2022)

#94

Earlier quoted context omitted.

> possibly I'm high but I find this rather amusing. Enjoy but don't play doctor until you get your degree. I'm not saying it's safe. In fact I think there's significant potential for harm from careless use of psychs, and I can't recommend it from a safety perspective. That being said, if you were going to use it - and this goes for any drug - you MUST test it. You cannot OD on 4 tabs of LSD. If it's actually 2C-B (it…

hey, it was and is all super friendly. and I am not saying it is unsafe. (have no idea, never partook. naturally exhibited behavior that apparently the "initiated" will interpret as micro-cruising. just this very day was attentively looking at bark, but thankfully no one caught me in the act.) so can we agree as hackernews friends that you exhibited questionable judgement (all ok, who is perfect) and you shouldn't go…

> "lsd is great, you should try it" is fine. "take this much and if you're on this is fine. i survived" is not, imho.

I guess I should have worded it differently.

The dose I took was actually ~1/2 a tab, as compared to starting with a full tab (the exact ug is basically impossible to know). Some people would view this as "wasting it". I think starting with a full tab would likely be overwhelming for some people, but I don't mean to say any ug is "safe" or recommended. It's just that a lot of people are going to do it anyway, and if they do I'd rather they have the best chance at being safe. This stuff isn't really well medically documented so it's basically all off "experiences".

I haven't used it in years, and I wasn't doing super well at the time.

Re: Effect of LSD on reinforcement learning in humans (2022)

#95

Earlier quoted context omitted.

hey, it was and is all super friendly. and I am not saying it is unsafe. (have no idea, never partook. naturally exhibited behavior that apparently the "initiated" will interpret as micro-cruising. just this very day was attentively looking at bark, but thankfully no one caught me in the act.) so can we agree as hackernews friends that you exhibited questionable judgement (all ok, who is perfect) and you shouldn't go…

> "lsd is great, you should try it" is fine. "take this much and if you're on this is fine. i survived" is not, imho. I guess I should have worded it differently. The dose I took was actually ~1/2 a tab, as compared to starting with a full tab (the exact ug is basically impossible to know). Some people would view this as "wasting it". I think starting with a full tab would likely be overwhelming for some people, but…

tbh am possibly too risk averse to have taken lsd on other medication myself, much less a-d. Depression sucks. Glad and hope you are doing better these days.

Re: Effect of LSD on reinforcement learning in humans (2022)

#96
post #75

Earlier quoted context omitted.

Even 15/20ug is quite a bit, which I would sometimes consider a minidose (depending on the setting). I detect even down to 5-7ug LSD that I'm dosed (though I'm quite experienced with all kinds of dosages). 75ug is definitely tripping-level. No way someone couldn't detect that they are dosed, just the contrast/visual-enhancing qualities alone should be enough to detect that, maybe even some LSD-typical distortions can…

Sorry but I have to ask. In what kinds of contexts did you become experienced? Is LSD in at least a gray area anywhere on earth? The country I come from that is an illegal drug, but it being a neuroplasticity enhancer is what attracted my attention. I've also read about microdosing which can enhance focus or creativity. Can it be prescribed for treating depression or other mental deficits or the approvals are not at…

Recreationally dosing in all kinds of settings and doses (e.g. microdosing in almost any setting on very different doses etc.). I have accurately tested LSD, so I know the exact dose I'm taking. Also I've done a bit of research of various scientific articles.

It's unfortunately not really legal though where I'm living.

AFAIK there are a few psychiatrists/researchers around the world where it's approved for clinical studies, where you could try it in a clinical setting. But unfortunately you're often still on your own with trying it. I tried microdosing it for treating ADHD, but I'm not really sure if it really helped there, and I'm back on the usual medications, YMMV though, as LSD has mild stimulant properties as well.

I may try a combination/mix of LSD and other ADHD medications in the near future though.

It being a neuroplasticity enhancer doesn't necessarily mean that it's enhancing in a good/healthy way. I noticed that my thoughts/imagination have gone a bit more "visual" (not sure if that's really the right term), I'm not sure if it really made me more creative. I think for me it mostly manifested my mind further and I'm a bit more in tune with nature etc. (much more conscious of all the "ecocrimes" humanity is doing).

This may not always be a good thing if e.g. you're prone to conspiracy theories. It can also mean that it's promoting growth in areas in the brain that shouldn't be connected (e.g. leading to psychosis), it's still a powerful substance which should be handled carefully.

But in general I think it still takes some time until this is a clinically approved substance. I think it will likely be for stuff like depression or PTSD or generally disorders originating mostly in the frontal lobe. I have certainly noticed the antidepressive properties of it (although I never had a real depression while taking it).

Re: Effect of LSD on reinforcement learning in humans (2022)

#97
post #75

Earlier quoted context omitted.

Even 15/20ug is quite a bit, which I would sometimes consider a minidose (depending on the setting). I detect even down to 5-7ug LSD that I'm dosed (though I'm quite experienced with all kinds of dosages). 75ug is definitely tripping-level. No way someone couldn't detect that they are dosed, just the contrast/visual-enhancing qualities alone should be enough to detect that, maybe even some LSD-typical distortions can…

Just a question but are you able to accurately measure down to 5-7ug to know that's how much you're testing? As I'm familiar with, tabs and other dosing with exception to volumetric are well known for large discrepancies in reported vs actual dose

Yeah liquid dosing, pretty sure I did it right, got accurate dosed acid as well (which is rare AFAIK). But even if it wouldn't super accurate, it's much more likely to be less acid than more.

But I'm quite hypersensitive to substances in general I think, so my experience may not be representative.

Re: Effect of LSD on reinforcement learning in humans (2022)

#98

Earlier quoted context omitted.

Not the parent, but you are correct in that NP-Hard includes also harder problems than the problems in NP. "At least NP-hard" is just "NP-hard".

I read that differently. There are harder problems in NP, in the same way there are 7ft tall people in the set of people over 6ft tall. So ‘at least NP hard’ I understood as ‘in NP but maybe in a subset of NP that is harder’.

Oh, so you mean like, supposing that NPI exists, an NPI problem? https://en.wikipedia.org/wiki/NP-intermediate

> There are harder problems in NP

That is an unresolved question. It might turn out that every problem in NP is equally hard. (Up to a polynomial translation cost.)

Re: Effect of LSD on reinforcement learning in humans (2022)

#99

This is a rather strange definition of 'learning', a better term would be 'behavioral modification.' Here's a definition of the practice: > "From an affective neuroscience perspective, our understanding of psychiatric illness may be advanced by neuropsychological test paradigms probing emotional processes. Reversal learning is one such process, whereby subjects must first acquire stimulus/reward and stimulus/punishme…

That's interesting, I've never heard about it attenuating 3D visualization capability. I know that some people are good at it and some people are not capable. My understanding of psychedelics is based in the plasticity model, so I felt or assumed that 3D visualization was just a flexing or practice using those skills, not acquisition of new skills

It might be plasticity in the sense that realizing those skills are worth spending time and energy on could be a result of ingesting such substances.

Re: Effect of LSD on reinforcement learning in humans (2022)

#100

Earlier quoted context omitted.

> ~50ug (which honestly I'd recommend for beginners) So says the guy who took LSD while on antidepressents. > EDIT: Sidenote, safety first friends. possibly I'm high but I find this rather amusing. Enjoy but don't play doctor until you get your degree.

> possibly I'm high but I find this rather amusing. Enjoy but don't play doctor until you get your degree. I'm not saying it's safe. In fact I think there's significant potential for harm from careless use of psychs, and I can't recommend it from a safety perspective. That being said, if you were going to use it - and this goes for any drug - you MUST test it. You cannot OD on 4 tabs of LSD. If it's actually 2C-B (it…

You must be thinking of something like 25B-NBOMe, not 2C-B. 2C-B is not potent enough to be dosed on blotter, and its lethal dose is unknown but expected to be quite high. https://en.m.wikipedia.org/wiki/2C-B
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