A socio-positivistic statistical study that involves a molecular substance-human interaction is already epistemically imprecise and type-theoretically invalid. You would want a molecular-human statistical study, even for just one person to obtain more precise objective data. Throw the experimental design out and try a responsively appropriate approach for the subject matter, I would advise.
Heavy marijuana use increases schizophrenia in men, study finds
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Re: Heavy marijuana use increases schizophrenia in men, study finds
#72Original journal article (apparently not linked to in the Bloomberg piece): Association between cannabis use disorder and schizophrenia stronger in young males than in females (May 4 2023) https://www.cambridge.org/core/journals/psychological-medici... Interestingly, the journal article doesn't bother to mention how cannabis use disorder (CUD) is defined; however, Bloomberg's description "frequent use despite negativ…
> Interestingly, the journal article doesn't bother to mention how cannabis use disorder (CUD) is defined; however, Bloomberg's description "frequent use despite negative consequences" is essentially that of the DSM, and so is presumably what they're using. Yes, it does: "CUD was identified in the same registers and supplemented with the somatic part of the National Patient Register, defined as ICD-8 code 304.5 and I…
Good catch. I scanned for it but missed it.
Re: Heavy marijuana use increases schizophrenia in men, study finds
#73[flagged]
Maybe so, but please don't post unsubstantive comments to Hacker News.
Re: Heavy marijuana use increases schizophrenia in men, study finds
#74Study is probably crap. An association between cannabis use and schizophrenia says nothing about which way the arrow of causation flows. It could very well be that cannabis use causes schizophrenia, or it could be that people feeling early signs of schizophrenia are more likely to use cannabis. There is no way to tell from this kind of study. Science is hard.
"Please don't post shallow dismissals, especially of other people's work. A good critical comment teaches us something."
"Avoid generic tangents."
Re: Heavy marijuana use increases schizophrenia in men, study finds
#75Earlier quoted context omitted.
15mg THC is 3x as much as I’d suggest to someone that doesn't use edibles no matter how familiar they are with smoking
Agreed, it's surprising to me that I've met many people who claim that edibles are terrible/terrifying. They often don't know how much they took and if they do it's usually way too much for the first time. I suspect it's a combination of bad design (a single gummy being >=10mg) and the fact that most people just don't read and comprehend the labels.
the labels exacerbate the bad design, switching between grams and ounces throughout, with THC content being in mg, and the product itself needing to be broken up to the actual serving size of half a gummy
Re: Heavy marijuana use increases schizophrenia in men, study finds
#76[flagged]
Re: Heavy marijuana use increases schizophrenia in men, study finds
#77I find that weed's effects just heighten a person's extremes. I become slow, almost indecisively slow on the stuff. It does calm my ADHD slightly, but it also helps me sleep. I also only use the stuff at night, generally an hour or two before bed and after all my needs are taken care of.
It turns my neurotic brother into a short-tempered asshole. He uses the stuff several times daily.
Guess people react differently to a whole variety of substances. Who knew?
Re: Heavy marijuana use increases schizophrenia in men, study finds
#78Frequent mouse button clicks increase software hangs in desktop environments, study finds. (MJ is an ancient medicine, it can't and won't cause any disease; proper use is a remedy for many)
arsenic and mercury are also ancient medicines...you want to start ingesting them daily?
Re: Heavy marijuana use increases schizophrenia in men, study finds
#79Study is probably crap. An association between cannabis use and schizophrenia says nothing about which way the arrow of causation flows. It could very well be that cannabis use causes schizophrenia, or it could be that people feeling early signs of schizophrenia are more likely to use cannabis. There is no way to tell from this kind of study. Science is hard.
I have read that Schizophrenics tend toward heavy smoking as well. Given that, it makes sense that they might try smoking something a bit more potent, though I'm not sure it would have the effect they're looking for.
I read the article looking for evidence of causation and didn't see it, so it could be either way. Maybe the actual study was more clear on this point.
Re: Heavy marijuana use increases schizophrenia in men, study finds
#80You have these cells in your brain called Microglia. They are responsible for cleaning up neurons and plaques and other weird proteins. These Microglia are activated by the firing neurons which release 2-AG and AEA (Anadamide). AEA binds to the CB1 receptor in these Microglia. 2-AG binds to CB2. THC binds to CB1. CBD binds to CB2.
Autistic adults have significantly low blood serum levels of AEA. Autistic people’s neurons prune slower. Schizophrenic people’s neurons prune faster.
It seems the ECS system is the principal driving mechanism behind both conditions. We need a lot more research in this area, but it could be THC has a positive neurological affect on Autistic people whereas finding a blocker for AEA binding on Microglia may result in a positive neurological affect on Schizophrenic people.
The next few years will be especially interesting.