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New insights into why aspirin works so well

eurekalert.org

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Re: New insights into why aspirin works so well

#151
post #100

Earlier quoted context omitted.

Which is riskier? One comment says it's paracetamol, another says it's ibuprofen..

He's probably referring to paracetamol's narrow therapeutic index[1]. 1 paracetamol may relieve your headache, 10 will do lasting damage to your liver, or even be fatal[2]. It's kind of nuts. Of course, Ibuprofen is not without (GI) issues, but I don't think it kills as many people as paracetamol does. [1] The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative…

Paracetamol toxicity is the foremost cause of acute liver failure in the Western world,

yup people are shocked when they learn it is good ol' Tylenol that is killing people or making them deathly ill, not those evil steroids or opioids hyped by the media. That is not to say those are not dangerous, but paracetamol is way easier to accidentally overdose. Taking to much of an oral steroid at once will not cause liver failure. Neither will too much codeine.

Re: New insights into why aspirin works so well

#152
post #108

Earlier quoted context omitted.

I have a friend who has suffered from something known as juvenile idiopathic arthritis since he was still a teenager, and he doesn't function very well without pretty decent doses of CBD for the past long while I've known him. I recognize legality issues are prohibitive in many parts of the world but if this is an option to you I would suggest trying this or anything else that takes the actual inflammation down inste…

According to Wikipedia [1] there is no proven medical effect to curcumin (the yellow substance from turmeric): Laboratory and clinical research have not confirmed any medical use for curcumin. It is difficult to study because it is both unstable and poorly bioavailable. It is unlikely to produce useful leads for drug development. [1]: https://en.wikipedia.org/wiki/Curcumin#Stability

There are no proven medical effects to many medicines that work wonderfully.

Re: New insights into why aspirin works so well

#153
post #31

Earlier quoted context omitted.

There's something like a downward spiral into hell that is opiates which starts with low doses like what you're on and escalates into worse and worse bullshit because you're not even trying to treat the underlying inflammation before masking the pain with opiates, and then the movement the pain is trying to prevent you from doing happens anyways and you just end up with more damage. I'm telling you these alternatives…

believe me, i know all about pain, from experience. cannabis derived products are not going to do anything, and i have no idea what you were going on about with tumeric. the only real actual pain-killers are opioids.

Arthritic pain can be treated by things other than pain killers, such as compounds with anti-inflammatory properties. That'd be the logic for turmeric I assume, in that same vein you have everything containing rosemarinic acid (Spearmint, oregano, rosemary).

Re: New insights into why aspirin works so well

#154

Earlier quoted context omitted.

No. Science has all along been testing if something works and then finding out why. Often the „why“ is orders of magnitudes harder to find out than the „if“. For example, we can observe how the brain functions in some instances, but why it works like does will elude us perhaps forever. Highly complex systems like the inner biomechanical workings of our brains are essentially a black box.

"Why" questions in general are pretty difficult question to answer in a satisfactory way. [1] https://www.youtube.com/watch?v=36GT2zI8lVA

I think “how” is more appropriate in the GP’s comment.

Re: New insights into why aspirin works so well

#155

"it can cause detrimental side effects such as internal bleeding and organ damage" NSAIDs are also ototoxic, meaning that they cause hearing damage.

Yeah, for all the hype about opioids being bad, these 'safe' drugs are way more dangerous than commonly purported. Acetaminophen is especially bad because the toxicity threshold is only slightly above the therapeutic dose. That is why they have to put so many warnings on this 'safe' drug. Yet let's blame opioids. https://en.wikipedia.org/wiki/Therapeutic_index

10:1 is still a pretty big ratio. You could take 20 Panadol every few hours before getting sick. That’s a LOT.

Re: New insights into why aspirin works so well

#156

When you say in 2023 that they have "new insights" as to why a common over the counter drug works it really doesn't instill great confidence in pharma. Seems like we're still grinding up rhino horns and tiger penis and hoping for the best outcome, just that we do it with extensive testing now so we get a statistically acceptable outcome viable for marketing.

If we could reliably show that ground rhino horns and tiger penises work, we'd be using them, or finding an easily mass produced derivatives.

If they'd work we we would quickly start trying to find the one chemical in them that is responsible for that, and once successful find a way to synthesize it from cheaper to source ingredients. In the end you'd just have an ointment that says "active ingredient: acetylsalicylic acid" and it's up to the marketing department whether they want to mention rhinos or not.

Re: New insights into why aspirin works so well

#157
post #6

Earlier quoted context omitted.

They are very safe when taken as prescribed but quite dangerous when you don't read the directions. Although IIRC taking fever reducers when sick significantly increases how long it takes to recover. Those fevers are there for a reason.

I guess theres always a caveat, but fevers can get too high and go for too long, in which case reducing the fever might be a good idea. But if it gets to that point, you should be working with a doctor to make those decisions.

This is a misnomer though. Your body will not make the fever too high in the case of fighting a virus, so danger is low. From an evolutionary standpoint this would make no sense. For a bacterial infection I think the chance of going to the danger zone is higher though.

Typically it's better to just let the fever ride when you have a virus, unless it's making you you so uncomfortable you can't rest/sleep.

Re: New insights into why aspirin works so well

#158
post #16

Earlier quoted context omitted.

thanks, but no thanks

There's something like a downward spiral into hell that is opiates which starts with low doses like what you're on and escalates into worse and worse bullshit because you're not even trying to treat the underlying inflammation before masking the pain with opiates, and then the movement the pain is trying to prevent you from doing happens anyways and you just end up with more damage. I'm telling you these alternatives…

Opiod abuse is no joke and they are about as addictive as prescription drugs get, and yet the abuse rate is something like 50% in developed Western countries (Abuse ranging from taking them slightly longer than you're supposed to, to taking more than your prescribed dose all the way to crushing and injecting). There are many millions of people who take opiods and don't get addicted or abuse them in any negatively impactful way.

Your comment is based on a personal bias and in no way based on medical fact. There are many types of pain that only opiods can treat. We absolutely need more options that are as powerful and less addictive.

The mechanism for addiction is well understood, but what we don't understand is why some people can take opiods, even extremely powerful ones and don't become drug fiends.

I am sitting here with two 250ml bottles of Morphine next to my bed, there is nothing stopping me from drinking it all. I know how it makes me feel, I know it eases my depression, removes my pain, clears my mind and calms my anxiety, I have restful sleep when I take it right before bed and yet I have never taken it when I didn't need to, never increased the dose, in fact I often take a lower dose than prescribed and sometimes don't take it as scheduled and subject myself to some of the pain until it reaches a point where I require relief, my goal is not to completely escape all pain, all the time, I like to remind myself that i am in control and that I'm not afraid of the pain and that experiencing 'some' pain is not a bad thing. However, I have seen all the documentaries and dramatisations and accounts of people who do the complete opposite. Perhaps it's because I have taken Ritalin for most of my life and am used to the sensations of cravings, perhaps it's because I don't drink alcohol and don't smoke, I do not have any addictive tendencies whatsoever (unless we're talking about chocolate!), maybe it's genetics, maybe it's socioeconomic, but for sure, for me in any case opioids have vastly and dramatically improved my quality of life and I'm grateful that we have such drugs available. Obviously there is work to be done on education, monitoring and support. I wonder if the opioid crisis is so bad in the US because of the private system and lack of coordinated care between specialists and clinics as well as lax pharmacy monitoring.

Re: New insights into why aspirin works so well

#159
post #155

Earlier quoted context omitted.

Yeah, for all the hype about opioids being bad, these 'safe' drugs are way more dangerous than commonly purported. Acetaminophen is especially bad because the toxicity threshold is only slightly above the therapeutic dose. That is why they have to put so many warnings on this 'safe' drug. Yet let's blame opioids. https://en.wikipedia.org/wiki/Therapeutic_index

10:1 is still a pretty big ratio. You could take 20 Panadol every few hours before getting sick. That’s a LOT.

not really. you will be quite sick before you hit 10. also, double dosing is a major problem and makes it easier to hit the threshold .

Re: New insights into why aspirin works so well

#160

Earlier quoted context omitted.

There's something like a downward spiral into hell that is opiates which starts with low doses like what you're on and escalates into worse and worse bullshit because you're not even trying to treat the underlying inflammation before masking the pain with opiates, and then the movement the pain is trying to prevent you from doing happens anyways and you just end up with more damage. I'm telling you these alternatives…

"just try weed bro" is the absolute worst most condescending advice you can give to someone suffering from chronic pain who didn't ask for advice. Do you really, really think someone just "went to opiates" before trying absolutely everything to identify and treat the underlying cause?

CBD is not equal to THC, its not psychoactive at all. So no it is not “just try weed bro” and the fact you are so confident about something you know nothing about is quite shocking to be honest. Also opiates are over prescribed for many things they shouldn’t be, so yes a lot of doctor “just went to opiates” and it is literally ruining lives.

P.S. the only condescending person in this thread is you.

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