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Earlier quoted context omitted.
“Single” in this case refers to the polymorphism not the segment length.
Could you elaborate on this? Are you claiming that SNPs do not generally refer to only one nucleotide?
I loved reading this. A nice short but true mystery solving story. But the epilogue about how being an electronics engineer gave them a bit of a unique edge feels like a self-serving stretch. The techniques in the story seem accessible to any reasonably well-learned individual if they’re motivated enough to sleuth. All the advanced work was done by other people. And there’s a tinge of the classic, “the established di…
It's a classic for a reason :)
Amazing! I wonder how much this rules out the espionage, or the connection to Jo Thomson though. I wonder if she sold him the poison or something. In any case, I am morbidly fascinated by stories of people dying alone, without children, and being forgotten. Perhaps because I feel it could be my own fate. Certainly more common than any of us are prepared for, as we are all decendents of the genetic winners.
No more successful relationships or sinister ways of ensuring genetic survival are required.
Amazing! I wonder how much this rules out the espionage, or the connection to Jo Thomson though. I wonder if she sold him the poison or something. In any case, I am morbidly fascinated by stories of people dying alone, without children, and being forgotten. Perhaps because I feel it could be my own fate. Certainly more common than any of us are prepared for, as we are all decendents of the genetic winners.
What fascinates me about this thought is that being a genetic winner in modern society could just mean you were qualified enough to donate to a sperm bank. No more successful relationships or sinister ways of ensuring genetic survival are required.
I loved reading this. A nice short but true mystery solving story. But the epilogue about how being an electronics engineer gave them a bit of a unique edge feels like a self-serving stretch. The techniques in the story seem accessible to any reasonably well-learned individual if they’re motivated enough to sleuth. All the advanced work was done by other people. And there’s a tinge of the classic, “the established di…
One year ago: https://www.youtube.com/watch?v=DCDOYDNZUMI 7 months ago: https://www.youtube.com/watch?v=ve_JrmYsU0I
Earlier quoted context omitted.
Could you elaborate on this? Are you claiming that SNPs do not generally refer to only one nucleotide?
According to wikipedia [1] it is a single nucleotide (or rather a single base pair). But you obviously need more base pairs to identify which base pair you are looking at in the DNA. Presumably 50-150 base pairs is the length of DNA fragments required to be able to identify where in the genome it is. [1]: https://en.wikipedia.org/wiki/Single-nucleotide_polymorphism
But that's not a SNP, then, that's a read that happens to contain a SNP.
Generally a SNP is addressed by giving the reference base, the mutated base, the chromosome, the base position in that chromosome, and the assembly used to align the read to that location. For example, a T->C mutation at chr2:25164877 using hg38.
Yes, you need to have the whole read to align to your genome assembly to detect the SNP. But before you do that, you don't know whether you have a SNP. And after you do that, the rest of the read is not useful if what you care about is the SNP.
Earlier quoted context omitted.
Could you elaborate on this? Are you claiming that SNPs do not generally refer to only one nucleotide?
There is another acronym, MNP, that means Multiple Nucleotide Polymorphism, but it's rarely used. It's very common to use SNP even if the variation is two or three nucleotides.
Alternately, they're talking about their sequencing reads and calling them SNPs.
I think I should just chalk this one up to my own personal Gell-Mann amnesia and let the article authors do their thing.
> Note that SNPs have around 50 to 150 base pairs of nucleotides What does this mean? SNPs being, by definition, single nucleotide polymorphisms, how does the author jump from 1bp to 50-150bp? Or is he referring to the surrounding DNA region?