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Lemon-derived nanoparticles block the progression of kidney stones

pubs.acs.org

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Re: Lemon-derived nanoparticles block the progression of kidney stones

#71

Post by qup »

sleepybrett wrote: post #52
malloci wrote: post #38

Earlier quoted context omitted.

I’ve known two people who have had kidney stones and I don’t think either of them would have been able to withstand the pain from the stone enough to go on a rollercoaster. Then again, maybe the promise of ending the pain will give enough motivation to grit it out.

I don't find they, at least the three I've passed, as particularly painful. It's more like an intense discomfort. I find myself in a cycle of pacing, laying down and sitting (mostly on the toilet, you feel like you have to pee constantly). It's like discomfort limbo.

Based on everyone else I've ever spoken with who had kidney stones (about six people), your experience is unusual.

Several have described it as the worst experience of their life, including one who has it recur a couple of times per year.

Re: Lemon-derived nanoparticles block the progression of kidney stones

#72

Post by lll-o-lll »

sleepybrett wrote: post #52
malloci wrote: post #38

Earlier quoted context omitted.

I’ve known two people who have had kidney stones and I don’t think either of them would have been able to withstand the pain from the stone enough to go on a rollercoaster. Then again, maybe the promise of ending the pain will give enough motivation to grit it out.

I don't find they, at least the three I've passed, as particularly painful. It's more like an intense discomfort. I find myself in a cycle of pacing, laying down and sitting (mostly on the toilet, you feel like you have to pee constantly). It's like discomfort limbo.

I think you’ve just been lucky. For me this was like being kicked in the balls. Except continually, for five days straight.

It’s organ pain, the worst of pains. My doctor said that research had shown it to be worse than birth pains (although my wife vehemently disagrees with this). Intense discomfort doesn’t begin to describe it.

Re: Lemon-derived nanoparticles block the progression of kidney stones

#74

Post by bmitc »

mrmincent wrote: post #67
bmitc wrote: post #61

Earlier quoted context omitted.

I don't think size has much to do with it, or at least there is no deterministic correlation to pain. Mine, just removed, was only 3-4mm, but it caused immense pain. The pain was 11/10, such that I cried and vomited from the pain, and the pain pushed through toradol, hydrocodone, and oxycodone. The second hydrocodone IV juice I got was described as 10x more potent than morphine. On my second ER visit in just two days…

That sounds horrible, something I don’t ever want to experience. I’m sorry you had to go through that, you’ve just convinced me to start including more lemon juice in my diet.

Yea, 0/10, would not recommend. Lol. Even dealing with the stent for four weeks was unpleasant. Everything's out now, and I'm so much better now. I think even just a lot water is supposed to help since it decreases concentrates.

Re: Lemon-derived nanoparticles block the progression of kidney stones

#75

Post by bmurphy1976 »

eigenvalue wrote: post #68
sgtnoodle wrote: post #39

Earlier quoted context omitted.

Do you to think crystals can form that quickly to have been caused by a single day of dehydration? I had one a couple years ago. My theory is that I had accumulated crystalization the year prior. I had a heart nerve issue and my heart rate was significantly reduced for several months, getting as bad as 30 bpm for a couple weeks. Normally it's about 80 bpm. My kidneys were definitely underperforming as indicated by bl…

I actually don’t know much about it from a medical standpoint. But just from a pure Bayesian reasoning it seems overwhelmingly likely to me that it was the precipitating cause, since I never had it before that. I do think most doctors are very weak at identifying or even understanding patterns that are very unusual and which they haven’t seen before or read about. They generally don’t rely on first principles thinkin…

They take time to build up. You probably knocked it loose during your exercise regimen and it got stuck in a new much worse place.

I get them regularly and I swear there are times where I feel a tightness that I attribute to one getting built up. Then one day the pain comes.

Re: Lemon-derived nanoparticles block the progression of kidney stones

#76

Post by bmitc »

bmurphy1976 wrote: post #70
bmitc wrote: post #61

Earlier quoted context omitted.

I don't think size has much to do with it, or at least there is no deterministic correlation to pain. Mine, just removed, was only 3-4mm, but it caused immense pain. The pain was 11/10, such that I cried and vomited from the pain, and the pain pushed through toradol, hydrocodone, and oxycodone. The second hydrocodone IV juice I got was described as 10x more potent than morphine. On my second ER visit in just two days…

Was your pain acute? I get a stone in my right kidney every 5 to 7 years. My pain is usually very acute. I like to describe it as somebody slamming a large needle into my abdomen. Think Uma Thurman in Pulp Fiction. These days my regimen is to avoid caffeine. I don't know if it's working, I had a year long relapse during COVID as caffeine free coke became unavailable. I'm due for my next one.

The pain was beyond acute. When it first occurred I was sitting on the couch. I went from being perfectly normal, to being slightly uncomfortable, to thinking I had a back or stomach cramp, to thinking I needed to use the restroom, to thinking I needed to go to urgent care, to knowing I needed to go to the emergency room all in about 5-10 minutes. But at times, the pain was so radiating that I thought my abdomen would explode. I honestly thought I would die any minute.

I've been caffeine free since 2020, stopping it due to severe anxiety during that whole debacle of a year. I have been dealing with acid reflux in the prior months, and I have a suspicion my stone was caused by low water intake and Tums. Hopefully the stone analysis correlates with that because it would be an easy fix. I'm certainly increasing my water intake now and staying completely away from Tums.

I hope to everything this is my only experience. It was my first stone, and I hope my last.

Re: Lemon-derived nanoparticles block the progression of kidney stones

#77

Post by bmurphy1976 »

malloci wrote: post #38
pubby wrote: post #34

Two fun facts about kidney stones: 1) Roller coasters help dislodge and pass kidney stones because of their high-intensity jerky motions. 2) Although calcium supplements increase the risk of kidney stones, dietary calcium seems to reduce it.

I’ve known two people who have had kidney stones and I don’t think either of them would have been able to withstand the pain from the stone enough to go on a rollercoaster. Then again, maybe the promise of ending the pain will give enough motivation to grit it out.

I had one that took a year to pass (and it was a big one). Only knocked me out for a couple hours every 2 to 3 months. Finally scheduled a procedure and I passed it one week before on Thanksgiving morning while cooking our dinner.

Had another smaller one that had me on hardcore painkillers for two straight weeks. It was so bad I wasn't eating or taking care of myself. I just popped pills and slept. Thankfully I was able to pull myself together and go back to the doctor to get on a different medication that at least allowed me to function minimally until I could pass it.

Point is you never really know what's going on in there and I certainly did go on some rides during the year of the larger yet somehow less bothersome stone.

Re: Lemon-derived nanoparticles block the progression of kidney stones

#78

Post by ChatGTP »

bitL wrote: post #42
ChatGTP wrote: post #20

Does anyone know if you can drink something to reduce the size of an existing stone ? I know it’s likely a “no”, but any novel treatments on the horizon ? I’ve received EWS and it’s not fun, did seem to reduce the size of a big stone I had though, 20mm

Take potassium citrate; eventually, drink a lot of beer.

Thanks I'll look it up!

Also, I took some time off the booze, oh the irony...

Re: Lemon-derived nanoparticles block the progression of kidney stones

#79

Post by car »

or113 wrote: post #73

Ask HN: I have Sialolithiasis, which is like kidney stones but in the upper throat/jaw. Any research like that? recommendations?

That’s stones in the salivary gland ducts. Can occur together with kidney stones. Sometimes caused by certain medications.

Re: Lemon-derived nanoparticles block the progression of kidney stones

#80

Post by aaron695 »

Here's my goat with urinary stones - https://imgur.com/a/q7K26Z5

They paw the ground when in pain. Stones can kill in 24 hours. A lot of money later he was ok.

We fed him ammonium chloride in case it was a struvite a phosphorus based stone (magnesium ammonium phosphate)

But in the end it was a calcium based stone which requires an operation, which can be deadly and costly, so this is interesting.

Full paper here - https://www.researchgate.net/publication/368169226_Lemon-Der...

But lemons will make struvite's worse since they are alkalizing and you need acidic.

(This is just rough in my head, research the medical stuff properly)

The sooner we have cheap devices that can see inside bodies the better.

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