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Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

independent.co.uk

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Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#201

Post by anovikov »

Rury wrote: post #194
anovikov wrote: post #26

Cynically speaking, main reason people lose weight, is looks and advantage in dating it gives (unless they are morbidly obese and at risk of severe illness or death due to that, of course). If there was a $25 a month drug that lets everyone become skinny, then what's the point? Advantage will cease to exist.

Perhaps some people have that mindset, but a lot of people do it for health. And I know some people may find that BS, but if you have ever lost significant amounts of weight before, you know how much better you feel and function.

I only wanted to say that a $1000 obesity drug is better than $25 obesity drug.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#202

Post by anonporridge »

lincolnq wrote: post #155
GaryNumanVevo wrote: post #137

Earlier quoted context omitted.

Surely eating healthier and exercising costs less than $12k a year right?

…no? Exercising 2h/week (close to the minimum) costs 100 hours per year, at $100/hr that’s close to 10k already and that doesn’t include the attention cost, or anything to do with diet

Every human still needs at least that amount of exercise (and ideally a lot more) to avoid cardiopulmonary disease, age related strength, balance, and bone density deterioration, and a myriad of other health issues, even if we could take a pill to cure obesity.

If you have to do it anyway to have a long healthspan, and it generally has the side effect of assisting in controlling weight, then why lean on the costly drug?

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#203

Post by anonporridge »

wincy wrote: post #190
GaryNumanVevo wrote: post #137

Earlier quoted context omitted.

Surely eating healthier and exercising costs less than $12k a year right?

Exercising has nothing to do with weight loss, although it’s still good for you with obvious benefits. Just losing weight is in my experience purely diet if you’re living any sort of standard American lifestyle where you’re really sedentary, or even moderately active. Maybe if you were like thru hiking you’d lose weight from exercise?

This is completely absurd in my personal experience. The amount of long duration, low intensity cardio I do has a massive effect on decreasing my weight with no dietary changes.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#204

Post by anaisbetts »

bedast wrote: post #36

Mounjaro is not an obesity drug. It's a type 2 diabetes drug. Do not call it an obesity drug. The headline is editorialized. The linked article's headline: The ‘next Ozempic’ became a social media sensation. Then everything changed The coupon didn't go away. The coupon's terms changed. I'm using the coupon now. Because I have type 2 diabetes. The coupon changed because people were using it to get the drug for off-lab…

> Leave the diabetes drugs alone.

Is artificially partitioning what is almost certainly the same medication (with the same manufacturing process) into two separate product lines actually a Good Thing? This means that when Mounjaro has supply problems even with the split, diabetics won't be able to get it because part of the supply is inaccessible to them since it is dedicated to a different "product".

Instead we should advocate for the real solution, which is to demand the manufacturer drastically increase production - Mounjaro along with Semaglutide have literally capital-S Solved one of the most urgent health epidemics of the 21st century, and the solution isn't to shame people for using it, the solution is to make it available to anyone who needs it.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#205

Post by nradov »

eyelidlessness wrote: post #193
HyperSane wrote: post #162

Earlier quoted context omitted.

With very few exceptions obesity is simply the result of eating more calories than needed for a long time. Very obese people eat a LOT of food. 10,000 calories/day for years is not uncommon.

From high school through nearly all of my adult life I’ve been obese. For the last several years my weight has barely fluctuated, but it’s fluctuated between caution about being underweight and a few pounds “overweight” that barely even count. I’ve eaten almost exactly the same the whole time. The two factors which changed: - I take ADHD meds, amphetamines, which are appetite suppressants. They haven’t made me eat le…

Odds are you are consuming more than 2000 kcal/day. Most people underestimate. Have you tried weighing and recording everything you consume for a couple weeks?

Anyone who wants to lose weight should start with a resting metabolic rate test in order to establish a baseline. You just sit in a chair for a few minutes while a machine measures your inhaled and exhaled gasses to calculate energy expenditure. If you consume fewer calories than your RMR then it is impossible to not lose weight.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#206

Post by HyperSane »

eyelidlessness wrote: post #193
HyperSane wrote: post #162

Earlier quoted context omitted.

With very few exceptions obesity is simply the result of eating more calories than needed for a long time. Very obese people eat a LOT of food. 10,000 calories/day for years is not uncommon.

From high school through nearly all of my adult life I’ve been obese. For the last several years my weight has barely fluctuated, but it’s fluctuated between caution about being underweight and a few pounds “overweight” that barely even count. I’ve eaten almost exactly the same the whole time. The two factors which changed: - I take ADHD meds, amphetamines, which are appetite suppressants. They haven’t made me eat le…

People are notorious for underestimating how many calories they are eating. Modern food is so cheap and delicious it isn't hard to eat 1000 calories in a few minutes. I lost weight by only eating food with accurate calorie information available that I could weight to the gram. I then used MyFitnessPal to track it and keep a 1000 calorie/day deficit.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#207

Post by nradov »

Dove wrote: post #187
HyperSane wrote: post #178

Earlier quoted context omitted.

All obesity is fundamentally caused by eating too much because fat contains energy that HAS to come from food.

Well, blood sugar contains energy that has to come from somewhere, too, but one would hardly say this means type 2 diabetes is fundamentally caused by eating too much. Shoot, tumors contain energy that has to come from somewhere... Of course, you could rightly reply that there are a lot of complicated things that happen between the food and the problem, and while those diseases require an energy surplus, that neither…

Type 2 diabetes is fundamentally caused by eating too much of carbohydrates. Most type 2 diabetics can put the condition into remission by changing their diet.

https://www.virtahealth.com/research

There are many people who have cured their obesity with a little bookkeeping and self control. Sue Reynolds and David Goggins are a couple of prominent examples, but there are many others. It's not easy, but it's certainly possible.

https://suereynolds.net/book/ https://davidgoggins.com/book/

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#208

Post by HyperSane »

kilgnad wrote: post #196
HyperSane wrote: post #162

Earlier quoted context omitted.

With very few exceptions obesity is simply the result of eating more calories than needed for a long time. Very obese people eat a LOT of food. 10,000 calories/day for years is not uncommon.

1 in 3 people in the US are obese. It is not just about eating more calories than needed for a long time. The story is much much more complicated then that given that 1 in 3 people are obese. It's like saying an overdose on heroin is simply someone doing too much heroin at a time.

"It is not just about eating more calories than needed for a long time."

Yes it is. It really is as simple as that, people just don't want to hear it. Historically food was scarce that it was nearly impossible to sustain a calorie surplus long enough to get fat. But some people did, that is why the rich used to be called "fat cats" but now calories are so cheap and delicious and lifestyles are so sedentary that it is very easy for almost anyone to sustain the caloric surplus needed to become very fat. I had a cousin who reached 650 pounds and then died. He would spend hours every day eating and almost as long shitting.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#209

Post by HyperSane »

perfecthjrjth wrote: post #188
HyperSane wrote: post #178

Earlier quoted context omitted.

All obesity is fundamentally caused by eating too much because fat contains energy that HAS to come from food.

Calories In Calories Out (CICO) doesn't explain obesity. You are dealing with biochemical machines (humans). CI enters this biochemical machine; here, the signal system should be effective to 'equalize'. Otherwise, you get all kinds of problems: obesity, t2d, cardiovascular events, etc. These new generation of drugs (semaglutide, tirzapatide) deal with the signaling system (endocrine signaling, that is).

"Calories In Calories Out (CICO) doesn't explain obesity."

Yes it does, because it is basically just repeating basic laws of thermodynamics. Obesity is actually just the body working as intended by storing the excess energy for future use during a famine. CICO is why obesity used to be very rare in past when calories were expensive and is now common when calories are very cheap and artificially delicious.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#210

Post by HyperSane »

kilgnad wrote: post #197
HyperSane wrote: post #178

Earlier quoted context omitted.

All obesity is fundamentally caused by eating too much because fat contains energy that HAS to come from food.

No. Absorption rates are different. Liquefied fat of the same calories translates to more fat then plant with the same calories. That's just an extreme example. The real culprit is processed foods.

The difference should not be enough to be the difference from a body fat percentage of 15% to 80%.
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