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Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

independent.co.uk

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Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#91

Post by bedast »

counttheforks wrote: post #84
bedast wrote: post #70

Earlier quoted context omitted.

Yeah, feel free to spend the $1200/mo for it then. Because that's off-label use when there are drugs in this class with on-label weight loss use. And sometime this year, tirzepatide is expected to be among them. The coupon was changed because people were abusing it. This drug is approved for diabetes, not weight loss.

Why are you defending the price gouging of the american healthcare system? Do you really only care about yourself?

I care that many people I know are losing glycemic control because they're going on a waiting list for their medication while Kim K and Elon Musk and TikTok promote easy mode cosmetic weight loss.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#92

Post by wonderwonder »

Retric wrote: post #34
ancientworldnow wrote: post #31

Earlier quoted context omitted.

Americans on average eat 400-700 more calories per day than in the 1970's. That explains it pretty well.

That’s simply restating the problem, the question is why people are eating more calories even as they are doing less physical labor.

My theory is over work, stress and a general feeling of being overwhelmed. It seems that there is never time to just relax and move at a normal pace anymore.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#93

Post by DangitBobby »

HDThoreaun wrote: post #74
msrenee wrote: post #64

Earlier quoted context omitted.

Are they the solution to obesity? I'm curious as to whether the weight stays off long term. 10 or more years at least or else it's just another bandaid. What we need is better access to nutritious food that doesn't take up so much of folk's scant downtime and tight income. I understand there's lots of reasons people are obese that aren't just laziness, but the drug doesn't solve those either. They're still not gettin…

Depressed people take ssri’s their entire life. People with ADHD take adderal or the like. I don’t see any reason to think of obesity as a different type of disease. Some people just find it extremely difficult to keep off weight, it doesn’t matter what kind of food they’re eating. Yes they could eat less, just like I could keep my thermostat at 45 in the winter to save on my heating bill. But that’s not a realistic…

It 100% matters what food you are eating, no matter who you are or what conditions you may have.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#94

Post by 6510 »

One of the flaws of our culture is that we madly overrate convenience. We think everything should be as easy as possible. It is taken as self evident but if you spend some thought on it it is hard to escape how important effort and accomplishment are. If we learn how to push ourselves we can take on slightly larger goals every time. Don't take my words as some kind of expert on the topic, if anything it reminds me constantly how damn lazy I am and how much worse it got. What kind of challenge you take up or find yourself in doesn't matter, it is all the same discipline. If I'm not careful the significant other will do all the house chores, cook the food and pay for everything. Imagine how appealing that sounds! This comment could have been a very lengthy article full of good references, the kind I haven't written in a long time. For this audience it could have used programming as it's context. What if after learning to read and write we would all learn to use a cli? Anyone could learn basic SQL and if we ever get the tools sorted out we could all consume API's. Very little effort and a huge reward. In stead some of us have to fight the html forms so that a baby can make very limited use of it. Lets have them type their name and their email and their address by hand? What horrific waste of time?

We already force people to go to school and in some countries you have to join the military but after that we are free to never exercise again and stuff our face with any kind of food we want the year round. If we are financially successful we will never have to use our brain. Can get drunk and stoned every day.... wonderful? You can smoke, drink coffee and watch tiktok indefinetly... at least until any kind of challenge presents it self. Then ur fucked. Not very funny in a personal context but as a society or a culture things should get rather bizarre as we pile up more and more convenience. We already have to import people to do the work.

It seems cheap universal healthcare isn't as hard as it seems. Putting out a small fire and cleaning up is cheaper than letting the entire city burn down before doing anything.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#95

Post by treis »

bedast wrote: post #65
Bluecobra wrote: post #11

> When someone takes an anti-obesity medication like Mounjaro, the amount of fat the body wants to maintain is re-regulated, usually to a lower weight. “When you take the medication away, that defended fat mass goes back up, and weight is regained,” Jastreboff said. “In order to continue to maintain the new re-regulated defended fat mass, and weight reduction, you have to continue taking the medication.” This doesn’t…

The biggest problem using these drugs for weight loss is they need to be used as part of a program that also includes making lifestyle changes. If you don't push the changes and just do things to your limits, when you stop the drug, your unchanged habits make you gain the weight back. This is one of the biggest things people with obesity struggle with. This is seen as a miracle cure for obesity because it doesn't req…

That's just not really true. People tend to gain weight and stabilize. It's not like they suddenly get will power. Most everyone has a weight they will end up at if they eat to satiation. These drugs lower that weight.

Of course will power and environment changes can keep you at a lower weight but it's a constant struggle against your body.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#96

Post by lm28469 »

fourseventy wrote: post #55
smallpipe wrote: post #13

The obese are mad at the diabetics, the diabetics are mad at the obese, while they should be mad at their failure of politicians who won’t regulate the drug market like any other functioning democracy. It’d be funny if it wasn’t so tragic

They should be mad at themselves for failing to take ownership over their own lives and health. But no, its someone elses fault that they eat an entire box of oreos every night.

That only works if you consider that everyone starts life as a well educated and healthy adult

When you factor in junk food marketing targeted to kids it starts to be a bit different. Then you add lobbies fighting to keep fast food in schools, the sugar industry, "fat makes you fat" and other clearly bs takes ...

What happened between the 50s and today that made https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6002a2.htm

Is it because 5 years old kids can't put the box of oreo down ? They must be stupid right ? Why can't they possess high level long term thinking ??? Don't they know about insulin resistance ? and calories ?

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#97

Post by RobotToaster »

lm28469 wrote: post #17
smallpipe wrote: post #13

The obese are mad at the diabetics, the diabetics are mad at the obese, while they should be mad at their failure of politicians who won’t regulate the drug market like any other functioning democracy. It’d be funny if it wasn’t so tragic

> who won’t regulate the drug market And the food industry, the real root cause of all of this

Regulating both would be good start.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#98

Post by [deleted] »

HDThoreaun wrote: post #54
lm28469 wrote: post #17

Earlier quoted context omitted.

> who won’t regulate the drug market And the food industry, the real root cause of all of this

Personally I’d like to thank the food industry for creating all these amazing products. I don’t think it’s anyone’s fault that some people find it very difficult to control the urge to eat too much, and I definitely don’t think I should be punished for that by making tasty food more expensive/harder to find.

[deleted]

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#99

Post by insapio »

HDThoreaun wrote: post #37

https://astralcodexten.substack.com/p/semaglutidonomics These new weight loss medications are the solution to obesity. Imo this is one of the biggest medical advances of the century and at least in urban areas of wealthy countries, I don’t think we’ll see obese people anymore in 10 years. The pharma companies realized they’ve got something truly revolutionary so they took the old tried and true drug dealer strategy.…

I take Mounjaro. For obesity. I thought back in '05 when I first started learning about DPP-4 inhibitors it wouldn't be too long before we realized obesity/T2DM were aspects of the same whole, but it'd take decades before we got to an effective therapy.

This is pretty much it. Zero side effects (other than the side effects from losing weight too fast, still have to pay attention to diet). We'll see if there's long term pancreatic/other issues down the line; but comparing risk against obesity, I still feel like I come out ahead on risk.

I expect to be taking some low level of a GLP/GIP/next-twincretin/next-tricretin forever. If I didn't now; I figure I'd keep running and dieting and meditating to steel my willpower; continue slighty overeating and slowly gaining fat and insulin resistance. And then I'd still end up taking a GLP/GIP years down the line after I finally developed T2DM.

I'd gladly spend $12k/year for the extra healthspan, and it seems many, many people are prepared to do the same.

Re: Diabetes drug Mounjaro was available at $25/month, then increased to $1k/month

#100

Post by pessimizer »

lm28469 wrote: post #59
HDThoreaun wrote: post #54

Earlier quoted context omitted.

Personally I’d like to thank the food industry for creating all these amazing products. I don’t think it’s anyone’s fault that some people find it very difficult to control the urge to eat too much, and I definitely don’t think I should be punished for that by making tasty food more expensive/harder to find.

Personally I'd like to thanks latin american cartels for making heroin feel so good, I don’t think it’s anyone’s fault that some people find it very difficult to control the urge to consume heroin, and I definitely don’t think I should be punished for that by making heroin more expensive/harder to find. Once your body is ravaged by years of junk food you're an addict in the medical sense of the term. When you give a…

Yes, they should make the food taste bad. That will make everyone better.
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