81–90 of 301 posts
Is the high cost of some of these drugs simply because they know the government will pay for it?
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Yeah, feel free to spend the $1200/mo for it then. Because that's off-label use when there are drugs in this class with on-label weight loss use. And sometime this year, tirzepatide is expected to be among them. The coupon was changed because people were abusing it. This drug is approved for diabetes, not weight loss.
Don't worry, it will be approved for the latter soon enough, perhaps under a different brand. No way to put this genie back in the bottle, sorry.
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That doesn’t explain why the rate of obesity has increased so dramatically over just a few decades. Like most widespread changes there are many root causes simply producing a massive surplus of food being an obvious requirement. If you’re selling food, getting people to consume more is simply more profitable. Various mechanisms kick in after someone gains weight to maintain that weight. Which is why the drug mentione…
"Choose" is the wrong word but you can certainly decide to change your weight, just as you can decide to give up smoking. It's hard to give up an addiction, and yes the companies peddling the addiction as an avenue to profit need to face a reckoning. But at the individual level, we can all choose what weight we want to be. Fatalism doesn't help anyone.
People can very much choose to lose weight, but it seems odd to say most people are then “choosing” to gain weight again. That said willpower does seems to account for a small percentage of overall weight so it very much does play a role.
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People aren’t stupid. Mounjaro is the most effective weight loss drug in existence. Better than wegovy and the other brand name semaglutides. If you think FDA approval is going to stop people from wanting and getting it you’re sorely mistaken.
Yeah, feel free to spend the $1200/mo for it then. Because that's off-label use when there are drugs in this class with on-label weight loss use. And sometime this year, tirzepatide is expected to be among them. The coupon was changed because people were abusing it. This drug is approved for diabetes, not weight loss.
Mounjaro is not an obesity drug. It's a type 2 diabetes drug. Do not call it an obesity drug. The headline is editorialized. The linked article's headline: The ‘next Ozempic’ became a social media sensation. Then everything changed The coupon didn't go away. The coupon's terms changed. I'm using the coupon now. Because I have type 2 diabetes. The coupon changed because people were using it to get the drug for off-lab…
This is an absurd argument. It's a drug. It has specific metabolic affects in humans that are valuable to people's health, among which are the control of blood glucose levels, and control of appetite and nutrient uptake, leading to loss of excess weight. That it is currently labeled only for Type 2 diabetes is a marketing decision by the manufacturer, not a characteristic of the drug.
Or, to put this another way: the drug is doing exactly the same thing whether you measure its effectiveness with a glucometer, or with a bathroom scale.
Mounjaro is not an obesity drug. It's a type 2 diabetes drug. Do not call it an obesity drug. The headline is editorialized. The linked article's headline: The ‘next Ozempic’ became a social media sensation. Then everything changed The coupon didn't go away. The coupon's terms changed. I'm using the coupon now. Because I have type 2 diabetes. The coupon changed because people were using it to get the drug for off-lab…
The diabetes and obesity versions are pharmacologically identical, the only difference is the name and price. Off label prescribing is extremely common, to treat specific drugs as special in that regard is silly.
Part of getting approval for on-label use of these drugs is understanding this part of it.
Pro tip, you can lose weight for free with no drugs at all.
This is easier for some people but not a solution for the general population.
Similarly, eating less is easier for some people while others are genetically or psychologically predisposed to eating more than they need.
The obese are mad at the diabetics, the diabetics are mad at the obese, while they should be mad at their failure of politicians who won’t regulate the drug market like any other functioning democracy. It’d be funny if it wasn’t so tragic
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Im well built, look decent with my shirt off and have a pretty good life but I hit a wall sometimes and just stress eat a gallon of ice cream. Lifting heavy weight for reps allows me to stay slightly ahead of my calorie consumption. I can see how a slightly more stressful life, less income and less time to work out could turn into a slippery slope where I would eat myself sick. I guess what I'm trying to say is that life is complicated. But your point stands.
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The real problem is not as a weight loss drug, but as a way to regulate diabetes. My girlfriend is on it, because the other medications don't work outside of insulin which has it's own difficulties. The sudden raise in price and her insurance refusing to pay for it means she either has to do it out of pocket or try and switch to something else which may or may not work. The real problem with using it as a weight loss…
> Eat too much and you get sick (seriously like 2 bites and you're done eating). While I’ve know some people experience more severe GI issues or nausea with the drug, this is quite the exaggeration. A drug that made it difficult or impossible to actually consume enough food to survive (more than “two bites”) would be wildly unsafe to prescribe.
Tragic to observe the typical Dallas Buyers Club dynamic at play. People are coordinating online and locally and doing border runs for the Mexico-available GLP-1 predecessors. The Mounjaro patent appears to be until '39, with no generics available at the moment. As one of the patients states in the article, obesity may very well lead them to diabetes. People will die. And with the shortage affecting current diabetics…
>obesity may very well lead them to diabetes. People will die. How scary! If only there was a reliable way for patients to prevent this disease :-(