Antidepressants help bacteria resist antibiotics: study

Post by wizzwizz4 » Wed, Jan 25, 2023, 11:18 PM UTC

metadat wrote: post #109

grammers wrote: post #91

Earlier quoted context omitted.

Exactly. And as long as antibiotics are produced in factories where the left overs are just sent into the drain as well (see India, China), anything else it just a tip of the iceberg. We need true emergency antibiotics - not once that are produced the way they are produced and not once that can still be used for animals.

Do you have any sources verifying the claim that these countries dump harmful chemicals directly down the drain without any neutralizing chemistry? Tragic and stupid beyond belief if this is true. Equivalent to using one's own kitchen sink as a toilet bowl.

Post by pfannkuchen » Wed, Jan 25, 2023, 11:59 PM UTC

Calavar wrote: post #57

pfannkuchen wrote: post #19

I’m a bit confused why antibiotic resistant bacteria is so scary. My layman understanding is that antibiotics gum up the mechanism to produce the cell wall. Sure, bacteria may develop where the mechanism works a bit differently and is not affected by a certain chemical. But it seems like “disrupt cell wall production” is a huge target and we could probably disrupt it in many other ways. Humans lack a cell wall entire…

This is a very good question. The practical issues with antibiotic resistance may not be that obvious to a layperson because they tend to pop up in the hospital setting as opposed to the clinic setting that most people are familiar with. The antibiotic bottleneck centers around patients who show up to the hospital with very vague signs of infection (fever, sweats, rigors, lethargy, etc.) and are sick . Like on the ve…

Post by password11 » Thu, Jan 26, 2023, 12:09 AM UTC

tokai wrote: post #53

nerdponx wrote: post #38

Earlier quoted context omitted.

But SSRIs reverse depression symptoms, they don't prevent it from happening in the first place. so the mechanism would have to be not just protection but some kind of restoration or rebalancing, maybe by selectively protecting some bacteria but not others. That seems a little less plausible to me.

SSRIs do lower the risk of further depressive episodes. "To conclude, this review provides evidence that continuing SSRIs for 1 year reduces risk of MDD and relapse." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761909/

Post by [deleted] » Thu, Jan 26, 2023, 12:40 AM UTC

lr4444lr wrote: post #30

andy_ppp wrote: post #7

I wonder if antidepressants protect your gut microbiome and the SSRI aspect is over stated. Would be very hard to disambiguate those two effects I suspect.

That was exactly my first thought. We could definitely throw the SSRI efficacy into doubt though by sampling CS fluid or something for actual serotonin content in cohorts who are subjectively feeling improved by SSRIs.

Post by refurb » Thu, Jan 26, 2023, 1:32 AM UTC

Ovah wrote: post #108

tokai wrote: post #4

Interesting and potentially dangerous. But as long as many millions of pigs are covered in antibiotic foam (which is just rinsed off into the drain), I'm not gonna lie sleepless over this. Resistant bacteria will cause humanity huge troubles if we don't manage to do something radical soon.

Is there any evidence that antibiotic resistance in any significant way crosses from livestock pathogens to human pathogens? I had a medical professor lecturing a couple years back saying it was basically a myth.