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Antidepressants help bacteria resist antibiotics: study

nature.com

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Re: Antidepressants help bacteria resist antibiotics: study

#21

Post by idontpost »

jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

> Being anti conspiracy and overly trusting of certain (cough cough) fields of science denotes an inability to rationalize.

That's some word salad right there.

Re: Antidepressants help bacteria resist antibiotics: study

#22

Post by lazyfanatic »

jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

once I know you have an agenda, I invalidate what you have to say.

Re: Antidepressants help bacteria resist antibiotics: study

#23

Post by frereubu »

dysoco wrote: post #20
bitxbitxbitcoin wrote: post #10

Earlier quoted context omitted.

That last sentence is often used to criticize economics but haven’t heard it on harder “sciences” before.

Not to diss on OP's comment, but out of context it sounds exactly like what COVID deniers usually say.

That's exactly what I took from "(cough cough) disorders".

Re: Antidepressants help bacteria resist antibiotics: study

#24

Post by ceejayoz »

lazyfanatic wrote: post #22
jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

once I know you have an agenda, I invalidate what you have to say.

Everyone has an agenda.

Re: Antidepressants help bacteria resist antibiotics: study

#25

Post by stackbutterflow »

efields wrote: post #17
stackbutterflow wrote: post #12

Earlier quoted context omitted.

The answer is phages. But last time I went into the rabbit hole the TLDR was that it is not patentable so there's no money in it. And everyone needs a different phages cocktail. I sleep at night knowing that push come to shove someone will step in and mass produce machines to create personal phage cocktails.

Is the implication here that antibiotics are more commercially viable, but phages are the real solution? I'm unfamiliar with phages, but a quick lookup revealed "virus that eats bacteria" and it's like, yeah… let's do that to combat bacterial infections. I'm guessing alignment between phage/bacteria is crucial.

Someone can correct me if I'm wrong but what I got was that there's nothing to patent because phages are found in sewers and mud pools as is. Also every individual with a bacterial infection needs a custom cocktail so there's no one-size-fits-all pill that can be mass produced.

Phages also have their own caveats but I don't remember what it is. The TLDR is that in the worst case scenario we still have phages and as far as I understand no bacteria can adapt to phages. But we need to figure out a way to make it commercially viable as you put it.

Re: Antidepressants help bacteria resist antibiotics: study

#26

Post by CollinEMac »

stackbutterflow wrote: post #12
tokai wrote: post #4

Interesting and potentially dangerous. But as long as many millions of pigs are covered in antibiotic foam (which is just rinsed off into the drain), I'm not gonna lie sleepless over this. Resistant bacteria will cause humanity huge troubles if we don't manage to do something radical soon.

The answer is phages. But last time I went into the rabbit hole the TLDR was that it is not patentable so there's no money in it. And everyone needs a different phages cocktail. I sleep at night knowing that push come to shove someone will step in and mass produce machines to create personal phage cocktails.

Could someone explain this to me like I'm 5?

Re: Antidepressants help bacteria resist antibiotics: study

#27

Post by make3 »

pfannkuchen wrote: post #19

I’m a bit confused why antibiotic resistant bacteria is so scary. My layman understanding is that antibiotics gum up the mechanism to produce the cell wall. Sure, bacteria may develop where the mechanism works a bit differently and is not affected by a certain chemical. But it seems like “disrupt cell wall production” is a huge target and we could probably disrupt it in many other ways. Humans lack a cell wall entire…

the products that both attacks the bacterias & are perfectly safe are probably very very hard to find, right. the product needs to be safe to flood your whole system with, because that's how pills work, you eat it and it diffuses everywhere in your system, there is zero targeting. Plus ideally it should kill all the bacterias very fast so none can develop resistance. it seems like it would be an incredibly hard balance.

Re: Antidepressants help bacteria resist antibiotics: study

#28

Post by phphphphp »

jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

I'm just a layman so perhaps you're referring to some top secret scientist internet but here on the normal internet it has been drilled into me through comments for as long as I can remember that a large part of anti-biotic resistance is being developed because of animal agriculture and that big food is responsible.

Re: Antidepressants help bacteria resist antibiotics: study

#29

Post by nerdponx »

londons_explore wrote: post #13
jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

> Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders This may be true in specific cases... But surely isn't true in general. It's the role of science and government to find out which anti-biotics, which hormones, and which pesticides case increased rates of which cancers. As soon as there is evidence suggesting a specif…

> It's the role of science and government to find out which anti-biotics, which hormones, and which pesticides case increased rates of which cancers.

Not necessarily.

One of several roles of government is to overcome coordination problems that would otherwise inhibit the production of public goods, such as new antibiotics and other better treatments for bacterial infections.

Another role of government is to regulate markets by creating incentives in the form of laws and legal regulations. In this case, government could estimate the societal cost of agricultural antibiotic use, and then impose taxes on agricultural antibiotic use equal to the amount of that cost. if those costs turn out to be punitive, then tough shit, they'll need to figure it out. The proceeds from tax is levied could then be redirected to basic research as needed.

Of course, this doesn't tend to work so well in practice due to any number of corruption and regulatory capture channels, so it tends to be easier to just ban harmful practices outright, which of course governments also have the power to do.

Re: Antidepressants help bacteria resist antibiotics: study

#30

Post by lr4444lr »

andy_ppp wrote: post #7

I wonder if antidepressants protect your gut microbiome and the SSRI aspect is over stated. Would be very hard to disambiguate those two effects I suspect.

That was exactly my first thought. We could definitely throw the SSRI efficacy into doubt though by sampling CS fluid or something for actual serotonin content in cohorts who are subjectively feeling improved by SSRIs.
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