Antidepressants help bacteria resist antibiotics: study • Hacker News Board

Re: Antidepressants help bacteria resist antibiotics: study

#91

Post by grammers » Wed, Jan 25, 2023, 8:34 PM UTC

tokai wrote: post #4

Interesting and potentially dangerous. But as long as many millions of pigs are covered in antibiotic foam (which is just rinsed off into the drain), I'm not gonna lie sleepless over this. Resistant bacteria will cause humanity huge troubles if we don't manage to do something radical soon.

Exactly. And as long as antibiotics are produced in factories where the left overs are just sent into the drain as well (see India, China), anything else it just a tip of the iceberg. We need true emergency antibiotics - not once that are produced the way they are produced and not once that can still be used for animals.

Re: Antidepressants help bacteria resist antibiotics: study

#92

Post by nerdponx » Wed, Jan 25, 2023, 8:46 PM UTC

debacle wrote: post #59

nerdponx wrote: post #33

Earlier quoted context omitted.

I'm not sure if this is a corollary or a counterpoint to what you're trying to say here, but not all agendas are equivalent. One person's agenda might be to make as much money as possible irrespective of consequences. Another person's agenda might be to decrease asthma rates. The fact that both people have some kind of agenda is basically irrelevant. This is the same hole as in the classic "both sides" political atti…

The Democrat party drummed up the "both sides" argument as cover for them turning their backs on the grassroots activism that got Barack Obama elected in 2008. In the same way, the modern focus on racial issues in the US is directly correlated with quelling the anti-classist Occupy movement. The lesser of two evils is still evil.

Source? Those are strong claims. I'm cynical enough to find them plausible, but they're strong enough that I'm not willing to take them for granted.

Re: Antidepressants help bacteria resist antibiotics: study

#93

Post by [deleted] » Wed, Jan 25, 2023, 8:46 PM UTC

dmix wrote: post #89

yawnxyz wrote: post #81

Earlier quoted context omitted.

Yay another phage thread! Phages do work, and we've treated a small bunch of people at Phage Australia for our clinical trial. There's a few things about using phages for treatments I think everyone should be aware of: (1) phages work!! The physicians we work with (and ourselves) are surprised every time they work. It's just really labor and time-intensive. (2) if antibiotics are "bite sized snacks" then phages are l…

I'm curious what drives customers to these services. Why would someone want to pay for a customized phage service? Someone who is taking lots of antibiotics or concerned about them?

[deleted]

Re: Antidepressants help bacteria resist antibiotics: study

#94

Post by bratwurst3000 » Wed, Jan 25, 2023, 8:47 PM UTC

John23832 wrote: post #49

bratwurst3000 wrote: post #45

Earlier quoted context omitted.

Isnt it that phages can be engeneered to a specific bacteria? Also the other way around. The can be programmed with the dna of the bacteria. So pcr the bacteria then make phages that atack them. My knowledge is bad . Could you elaborate where the engeneering problem is and the cost factors? Thanks

The problem is that they are highly specific. You would need the industrial machinery to manufacture a highly specific treatment. With anything in medicine/biology, specificity dramatically increases cost. There's also the pre-treatment testing that would be necessary to determine what to target. There's also the shipment of a bacterial specimen that would be used to create a phage (which is something we don't do cur…

Thank you very much. I google a bit and here in germany we are allready building a database and a stock of phagea for specific bacteria. They allready have over 1000 phages. They also have „phage cocktails“ for broadband. They also state your points. Thanks again. Here the link in german

https://www.dsmz.de/press/press-releases/singleview/zertifiz...

And this video is rly interesting https://m.youtube.com/watch?v=YI3tsmFsrOg

Re: Antidepressants help bacteria resist antibiotics: study

#95

Post by [deleted] » Wed, Jan 25, 2023, 8:49 PM UTC

kranke155 wrote: post #73

jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

Can you share sources, studies, be more specific ?

[deleted]

Re: Antidepressants help bacteria resist antibiotics: study

#96

Post by Traubenfuchs » Wed, Jan 25, 2023, 8:52 PM UTC

CorrectHorseBat wrote: post #87

Traubenfuchs wrote: post #34

Earlier quoted context omitted.

Not just higher life is plagued by viruses, bacteria as well. And bacteriophages are viruses that only target specific bacteria. They are among the most abundant "forms of life" in the whole world, as google details: > There are up to ten times more phages in the oceans than there are bacteria, reaching levels of 250 million bacteriophages per millilitre of seawater. If we were able to quickly find the right phage fo…

>Not just higher life is plagued by viruses, bacteria as well. And bacteriophages are viruses that only target specific bacteria. And not even viruses are safe from viruses: https://en.m.wikipedia.org/wiki/Virophage

I didn’t know. Ridiculous nonsense like that makes a somewhat intelligent, playful, curious designer of life a possibility to me...

Re: Antidepressants help bacteria resist antibiotics: study

#97

Post by Traubenfuchs » Wed, Jan 25, 2023, 8:55 PM UTC

hfsh wrote: post #78

Traubenfuchs wrote: post #34

Earlier quoted context omitted.

Not just higher life is plagued by viruses, bacteria as well. And bacteriophages are viruses that only target specific bacteria. They are among the most abundant "forms of life" in the whole world, as google details: > There are up to ten times more phages in the oceans than there are bacteria, reaching levels of 250 million bacteriophages per millilitre of seawater. If we were able to quickly find the right phage fo…

> by design Yeah, no. Quite the opposite in fact.

All I wanted to say here was: Anything infectable by a virus can not become immune to viruses as a whole. There is always a new virus variant/mutation out there, or possible to come into existence, that kills the bacteria.

Re: Antidepressants help bacteria resist antibiotics: study

#98

Post by jklinger410 » Wed, Jan 25, 2023, 9:01 PM UTC

formerly_proven wrote: post #56

jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

> increased rates of cancer and other (cough cough) disorders Can someone translate dogwhistle to english here please?

The cough cough is not a reference towards respiration. At this point, I wish I would have left it out.

But there are a myriad of illnesses that have been linked to environmental pollutants and a very high number of people will get offended if you point it out. Because the science isn't settled yet. I'll let you fill in the blanks there.

Re: Antidepressants help bacteria resist antibiotics: study

#99

Post by zackmorris » Wed, Jan 25, 2023, 9:08 PM UTC

andy_ppp wrote: post #7

I wonder if antidepressants protect your gut microbiome and the SSRI aspect is over stated. Would be very hard to disambiguate those two effects I suspect.

Good insight. I went through a profound burnout in 2019 after I lost my digestive health and got low serotonin due to a combination of work stress, overtraining at the gym, dehydration and a finger of booze after particularly hard days. Also food sensitivities to legumes, nightshades and almond butter, which I wasn't aware of at the time. I just learned that 25% of people who get food poisoning go on to develop IBS. Don't eat gas station sushi when you're on vacation!

https://experiencelife.lifetime.life/article/the-food-poison...

Ashwagandha basically restored my gut health in 3 months, in combination with psyllium husk capsules, kefir, and large plain lettuce salads with a vinegar-based dressing. My theory is that my cortisol levels got so high after decades of stress and negative reinforcement that I had symptoms like Cushing's syndrome. So ashwagandha mopped that up, which raises testosterone/estrogen and probably fixes a whole host of issues. But I never tested those levels, so take that with a grain of salt.

I've experienced the connection between gut health and mood, now I do everything I can to stay in good shape. But I've noticed a resistance to this line of thinking, especially in older people who just want a pill from their doctor.

Re: Antidepressants help bacteria resist antibiotics: study

#100

Post by anigbrowl » Wed, Jan 25, 2023, 9:08 PM UTC

jklinger410 wrote: post #55

airstrike wrote: post #47

Earlier quoted context omitted.

> It's the role of science and government to find out which anti-biotics, which hormones, and which pesticides case increased rates of which cancers. Not if you subscribe to the precautionary principle https://en.wikipedia.org/wiki/Precautionary_principle "The principle is often used by policy makers in situations where there is the possibility of harm from making a certain decision (e.g. taking a particular course o…

But imagine how much revenue we'd be missing out on if every new invention that could shave a few cents off the bottom line had to be researched first? Just one of many brilliant decisions that the primarily white men who have ran this country throughout history made on behalf of all of us. Without our consent, of course. Good luck proving your dad's colon cancer was caused by industrial solvents in our water supply.…

I think it's more useful to look at this as a class/economic leverage issue, as selfishness and the use of administrative power to extract economic rents seems to be a universal phenomenon. 'White' as a proxy for the racialized dynamics of European colonialism is sometimes a convenient shorthand, but glosses over other important contexts like white being a symbol of monarchy, because the aristocratic class were not required to labor outdoors. This intraracial social marker was significant enough to appear in flags: https://en.wikipedia.org/wiki/White_flag#Ancien_R%C3%A9gime_...

The 'white Russians' that fought against the 'red' communists carried the association of whiteness with traditional monarchy forwards into the 20th century and this revanchist monarchism continues to shape radical politics and factional identities in the present, although the symbolism is so diluted as to be unrecognizable to most: https://en.wikipedia.org/wiki/White_movement

If we only look at 'white identities' in terms of racial coding, we fall into the trap of inadvertently criticizing people for a fact about themselves they didn't choose and can't change, and whose structural social privileges (vs those of non-European origin) are so unevenly distributed that the resulting intra-ethnic discontent has to be micromanaged through an elaborate ideological apparatus.