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Antidepressants help bacteria resist antibiotics: study

nature.com

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Re: Antidepressants help bacteria resist antibiotics: study

#71

Post by ronsor »

stackbutterflow wrote: post #12
tokai wrote: post #4

Interesting and potentially dangerous. But as long as many millions of pigs are covered in antibiotic foam (which is just rinsed off into the drain), I'm not gonna lie sleepless over this. Resistant bacteria will cause humanity huge troubles if we don't manage to do something radical soon.

The answer is phages. But last time I went into the rabbit hole the TLDR was that it is not patentable so there's no money in it. And everyone needs a different phages cocktail. I sleep at night knowing that push come to shove someone will step in and mass produce machines to create personal phage cocktails.

Sounds like the solution is to kill patents so they can forget about money entirely.

Re: Antidepressants help bacteria resist antibiotics: study

#72

Post by nerdponx »

jklinger410 wrote: post #55
airstrike wrote: post #47

Earlier quoted context omitted.

> It's the role of science and government to find out which anti-biotics, which hormones, and which pesticides case increased rates of which cancers. Not if you subscribe to the precautionary principle https://en.wikipedia.org/wiki/Precautionary_principle "The principle is often used by policy makers in situations where there is the possibility of harm from making a certain decision (e.g. taking a particular course o…

But imagine how much revenue we'd be missing out on if every new invention that could shave a few cents off the bottom line had to be researched first? Just one of many brilliant decisions that the primarily white men who have ran this country throughout history made on behalf of all of us. Without our consent, of course. Good luck proving your dad's colon cancer was caused by industrial solvents in our water supply.…

I assume you're being downvoted because of the unnecessary reference to "white men". The sentiment here is spot on, but really, this is one area where race doesn't matter much. There are plenty of white people suffering from this stuff as well. There's definitely some value in looking at this through a critical race theory lens, as with most issues in the USA, but in this case you might say that the CRT model has poor explanatory power.

Re: Antidepressants help bacteria resist antibiotics: study

#73

Post by kranke155 »

jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

Can you share sources, studies, be more specific ?

Re: Antidepressants help bacteria resist antibiotics: study

#74

Post by xen2xen1 »

formerly_proven wrote: post #56
jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

> increased rates of cancer and other (cough cough) disorders Can someone translate dogwhistle to english here please?

Assumed Covid, but hard to say.

Re: Antidepressants help bacteria resist antibiotics: study

#75

Post by standardUser »

jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

Generous of you to think it's "unknowingly". There is a strange phenomenon online where people rush to oppose things like basic animal welfare and improved food labelling or any other change to the food industry. I find it hard to swallow that there's so many regular people out there passionately defending the rights of corporations to torture animals and hide what's in their food in their free time.

Re: Antidepressants help bacteria resist antibiotics: study

#76

Post by standardUser »

londons_explore wrote: post #13
jklinger410 wrote: post #9

Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders in the same way big oil knew that it was contributing to/causing global warming. Every person in the comments across the internet saying the rise in all of these disorders was just about self-reporting have been unknowingly shilling for big food. Being anti conspiracy a…

> Factory farm companies have known that anti-biotics, hormones, and pesticides are causing increased rates of cancer and other (cough cough) disorders This may be true in specific cases... But surely isn't true in general. It's the role of science and government to find out which anti-biotics, which hormones, and which pesticides case increased rates of which cancers. As soon as there is evidence suggesting a specif…

Better to have comprehensive information available about every aspect of our food supply so individuals can make decisions based on the science as it evolves and not have to wait for government action (which always comes last).

Re: Antidepressants help bacteria resist antibiotics: study

#77

Post by NickM »

lr4444lr wrote: post #30
andy_ppp wrote: post #7

I wonder if antidepressants protect your gut microbiome and the SSRI aspect is over stated. Would be very hard to disambiguate those two effects I suspect.

That was exactly my first thought. We could definitely throw the SSRI efficacy into doubt though by sampling CS fluid or something for actual serotonin content in cohorts who are subjectively feeling improved by SSRIs.

SSRI efficacy is already in doubt, as roughly 80% of the beneficial effects are replicated by placebos; some research has suggested that the remaining difference is due to the side effects, which make SSRIs active placebos and mess with study blinding.

And, even if they are better than just an active placebo, the mechanism is probably not the effects on serotonin levels. (Discussed previously here: https://news.ycombinator.com/item?id=32160703)

Re: Antidepressants help bacteria resist antibiotics: study

#78

Post by hfsh »

Traubenfuchs wrote: post #34
CollinEMac wrote: post #26

Earlier quoted context omitted.

Could someone explain this to me like I'm 5?

Not just higher life is plagued by viruses, bacteria as well. And bacteriophages are viruses that only target specific bacteria. They are among the most abundant "forms of life" in the whole world, as google details: > There are up to ten times more phages in the oceans than there are bacteria, reaching levels of 250 million bacteriophages per millilitre of seawater. If we were able to quickly find the right phage fo…

> by design

Yeah, no. Quite the opposite in fact.

Re: Antidepressants help bacteria resist antibiotics: study

#79

Post by eastbound »

throwanem wrote: post #70
jklinger410 wrote: post #52

Earlier quoted context omitted.

Cough cough was not a respiratory reference. I simply am not going to stir up the pot by directly mentioning the fields that are corrupt or the specific disorders.

Why should anyone take you seriously when you openly admit lacking the courage of your convictions?

[flagged]

Re: Antidepressants help bacteria resist antibiotics: study

#80

Post by shagie »

John23832 wrote: post #31
pfannkuchen wrote: post #19

I’m a bit confused why antibiotic resistant bacteria is so scary. My layman understanding is that antibiotics gum up the mechanism to produce the cell wall. Sure, bacteria may develop where the mechanism works a bit differently and is not affected by a certain chemical. But it seems like “disrupt cell wall production” is a huge target and we could probably disrupt it in many other ways. Humans lack a cell wall entire…

> I’m a bit confused why antibiotic resistant bacteria is so scary. It's scary because if you can't kill the bacteria, the bacteria kills you. -- > My layman understanding is that antibiotics gum up the mechanism to produce the cell wall. This layman's idea is incorrect. Not all antibiotics work on cell walls. Not all bacteria have defined cell walls. Look up Mycoplasma. -- > Is the concern that studies to confirm la…

> There's a metric crap ton of money going into the research of new antibiotics

It's getting more attention, but its been faltering for a long time.

https://news.bloomberglaw.com/health-law-and-business/antibi...

> Venture capitalists are investing far less funds to develop new antibiotics than they are for oncology drugs, according to a new report that highlights the need for more financial incentives to fight off the growing threat of drug-resistant bacteria.

> The report, published Monday by the Biotechnology Innovation Organization, found that investors are increasingly shying away from antibiotic research due in part to large companies exiting the space. That’s left small companies, that typically rely on investment capital, struggling to carry out new clinical trials.

> Newer antibiotics are more important than ever as the Covid-19 pandemic has forced people into hospitals for longer periods of time, increasing the chances for the spread of antibiotic-resistant germs, the biotech trade group said.

> But in the past 10 years, venture capital funding for U.S. antibiotic development amounted to $1.6 billion, compared to $26.5 billion for oncology, according to Monday’s report. The group noted that there are currently 64 new antibacterial therapeutics in the clinical trial pipeline, 80% of which originated from small companies.

The report mentioned is The State of Innovation in Antibacterial Therapeutics - https://www.bio.org/sites/default/files/2022-04/BIO-Antibact...

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