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Long Covid: major findings, mechanisms and recommendations

nature.com

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Re: Long Covid: major findings, mechanisms and recommendations

#141

Post by seydor »

jandrewrogers wrote: post #116
Animats wrote: post #45

This is really bad. Important points: * About 10% of people getting COVID get some form of long COVID. * There's long term damage. At least years. Maybe permanent in some cases. * You can get COVID more than once.[1] Somewhere above 6-10% of infections are re-infections, and that number increases over time. Immunity seems to last 3-18 months. What is this going to look like in 5 years? 30% - 40% of the population dis…

I’ve had COVID multiple times — I collect variants like Pokémon cards. The first one (pre-vaccine!) was nasty with a few lingering effects that went away after a month, the last was asymptomatic. In everyone I know that has had multiple infections — which is a lot of people these days — subsequent infections are much less consequential than the last, including lingering effects. This is what you would generally expec…

The studies tell the opposite. A large study in US veterans found increased risk in 2 and 3 times reinfected, including death

https://www.reuters.com/business/healthcare-pharmaceuticals/...

> Reinfected patients had a more than doubled risk of death and a more than tripled risk of hospitalization compared with those who were infected with COVID just once. They also had elevated risks for problems with lungs, heart, blood, kidneys, diabetes, mental health, bones and muscles, and neurological disorders

> priced into most peoples’ view of COVID

I 'm curious who this view is formed. Is it hearsay? Because there's probably no empirical data supporting that view

Re: Long Covid: major findings, mechanisms and recommendations

#142

Post by seydor »

incrudible wrote: post #138
Animats wrote: post #124

Earlier quoted context omitted.

> That assumes likelihood of getting long COVID doesn't drop after successive infections. It's not looking good. December 2022 study [1][2]: "The risk of hospitalization, organ damage, and death rises markedly with repeat COVID-19 infection. Assistant professor of medicine Amy Barczak shared a Nature study that used data from the Veteran’s Administration to assess the cumulative risk of post-infection effects in peop…

People always cite the Veterans affair study to support the claim that reinfections are more severe, without citing this paragraph that makes it clear that this study can not support that claim: Our analyses should not be interpreted as an assessment of severity of a second infection versus that of a first infection, nor should they be interpreted as an examination of the risks of adverse health outcomes after a seco…

does it really matter, if even a mild reinfection increases your risk of so many diseases and death?

Re: Long Covid: major findings, mechanisms and recommendations

#143

Post by seydor »

dehrmann wrote: post #53
Animats wrote: post #45

This is really bad. Important points: * About 10% of people getting COVID get some form of long COVID. * There's long term damage. At least years. Maybe permanent in some cases. * You can get COVID more than once.[1] Somewhere above 6-10% of infections are re-infections, and that number increases over time. Immunity seems to last 3-18 months. What is this going to look like in 5 years? 30% - 40% of the population dis…

> 30% - 40% of the population disabled? That assumes likelihood of getting long covid doesn't drop after successive infections.

Some studies that infection actually may make it easier to catch it again

https://www.science.org/doi/10.1126/science.abq1841

and that covid causes immunological dysfuction even 8 months later

https://www.nature.com/articles/s41590-021-01113-x

Re: Long Covid: major findings, mechanisms and recommendations

#144

Post by seydor »

There are simple changes that don't affect people's lives but can promote protection to those that want to be protected. Longer winter school breaks (instead of summer) could somehow mitigate the flu/cold/covid season. Remote work helps, as does the normalization of wearing masks (and perhaps stop politicizing it)

Re: Long Covid: major findings, mechanisms and recommendations

#145

Post by parthianshotgun »

lossolo wrote: post #42
alchemist1e9 wrote: post #22

Earlier quoted context omitted.

Except for me and many others long covid symptoms got worse after vaccination. Additionally new research is uncovering serious and significant risks for the vaccine with fairly marginal protection benefits.

> Additionally new research is uncovering serious and significant risks for the vaccine with fairly marginal protection benefits. Could you provide a link to that research ?

[flagged]

Re: Long Covid: major findings, mechanisms and recommendations

#146

Post by dham »

seydor wrote: post #141
jandrewrogers wrote: post #116

Earlier quoted context omitted.

I’ve had COVID multiple times — I collect variants like Pokémon cards. The first one (pre-vaccine!) was nasty with a few lingering effects that went away after a month, the last was asymptomatic. In everyone I know that has had multiple infections — which is a lot of people these days — subsequent infections are much less consequential than the last, including lingering effects. This is what you would generally expec…

The studies tell the opposite. A large study in US veterans found increased risk in 2 and 3 times reinfected, including death https://www.reuters.com/business/healthcare-pharmaceuticals/... > Reinfected patients had a more than doubled risk of death and a more than tripled risk of hospitalization compared with those who were infected with COVID just once. They also had elevated risks for problems with lungs, heart, b…

From article:

> Experts not involved with the study said the VA population does not reflect the general population.

> Patients at VA health facilities are generally older, sicker people and often men, a group that would typically have more than normal health complications, said John Moore, a professor of microbiology and immunology at Weill Cornell Medical College in New York.

Re: Long Covid: major findings, mechanisms and recommendations

#147

Post by dham »

moistly wrote: post #92
godelski wrote: post #21

Earlier quoted context omitted.

Maybe I'm being generous to the parent, but I also would like a comparison to the flu. Not because I don't believe covid is significantly worse (when I got it, it was way worse than the flu), but because I don't have a medical background and it is difficult to contextualize the actual risks here without some baseline where I have a decent intuition already built around. But where I disagree with the parent is the nee…

But have you actually had the flu? I ask, because most people say “oh, I had the flu” when in actuality they just had a common cold. The flu, the real flu, knocks you on the ass so hard that you actively start considering that death is a possibility and that heading over to the hospital would be a good idea. I’ve had the flu perhaps twice. Once as a child, once in my early 50s. The latter completely recalibrated my u…

Yea, that's been my experience. Incredibly frustrating. Pre Covid, people at work would put on Slack they "had the flu they can't work today". Or "I had the flu this weekend". What they don't know is if you have the flu you literally can't move from bed and the thought of typing into Slack would be a task too great.

Re: Long Covid: major findings, mechanisms and recommendations

#148

Post by incrudible »

seydor wrote: post #142
incrudible wrote: post #138

Earlier quoted context omitted.

People always cite the Veterans affair study to support the claim that reinfections are more severe, without citing this paragraph that makes it clear that this study can not support that claim: Our analyses should not be interpreted as an assessment of severity of a second infection versus that of a first infection, nor should they be interpreted as an examination of the risks of adverse health outcomes after a seco…

does it really matter, if even a mild reinfection increases your risk of so many diseases and death?

It does matter whether the science is misprepresented, causing irrational anxiety in people, which also increases your risk of "so many diseases and death".

Respiratory infections generally increase your risk for various pathologies, but so does staying indoors in fear, not getting exercise and avoiding social contact.

Re: Long Covid: major findings, mechanisms and recommendations

#149

Post by eismcc »

nradov wrote: post #105
eismcc wrote: post #56

Earlier quoted context omitted.

I found popular ones on Amazon. I tried it because of doing research on my high numbers for Epstein-Barr (aka mono). I found via NIH papers that liver issues are common with mono patients so I figured I could be having that since there were no other obvious blood results. I had Covid beforehand and when I had extreme fatigue I had the mono tests done. The EBV numbers were off the charts and then I found some NIH pape…

What is the active ingredient of that supplement?

Liver Cleanse Detox & Repair Formula - Herbal Liver Support Supplement with Milk Thistle Dandelion Root Organic Turmeric and Artichoke Extract for Liver Health - Silymarin Milk Thistle Detox Capsules https://a.co/d/i9QCiCV

Re: Long Covid: major findings, mechanisms and recommendations

#150

Post by psychphysic »

ggm wrote: post #76
jupp0r wrote: post #66

Earlier quoted context omitted.

It's kind if important whether you develop long covid or not. If you don't then you don't need a long break, if you do, you could be out for months or forever.

And, exercise makes it worse for some people. So "push through" is a possibly terrible idea.

Seems like long COVID and CFS are being conflated here.
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