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‘Breakthrough’ obesity drugs that have stunned researchers

nature.com

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#921

Post by CadmiumYellow »

grecy wrote: post #795
CadmiumYellow wrote: post #480

Earlier quoted context omitted.

The first time I tried ketchup after strictly avoiding added sugars for several weeks was a WILD experience. It tasted sweeter than maple syrup. I used to douse my food in ketchup and now I can't even eat it on fries because it's so sickeningly sweet. I noticed the same with most bottled salad dressings and sauces (barbecue sauce and honey mustard being even more egregious than ketchup).

I just came back to North America after 18 months in Australia. Ketchup compared to Tomato Sauce is a wild difference!

Is it?! Maybe I need to order some tomato sauce from Australia. I miss ketchup, I just want it to taste like salt/vinegar/tomato like it used to before I noticed the sugar.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#922

Post by donkarma »

UI_at_80x24 wrote: post #196
bitwize wrote: post #153

Why use drugs and lifestyle changes when lifestyle changes alone will do the trick? Everybody knows you're not a real Hackernews until you adopt a cold, calculating, "food is fuel" mentality toward eating, with extensive data collection, strict timing, data-driven portion control, and long fasting periods. Once you do that you don't need the drugs and can tell Big Pharma where to shove it.

Lifestyle change alone is NOT all it takes. I've been fat all of my life, so has everybody in the last 3 generations of genetic contributors. I can easily drop 20-40lbs if I cut sugar out of my diet. Then it stops. I've cycled 15miles/day for 7 years (on non-snowy days). During that time I went on a water-only fast, (7days on, eat one day, then 14days eat one day, then 7 days more of fasting before I stopped.) I lost…

[dead]

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#923

Post by adamsmith143 »

paulpauper wrote: post #494
adamsmith143 wrote: post #483

Earlier quoted context omitted.

https://slimemoldtimemold.com/2021/07/07/a-chemical-hunger-p... TLDR: The modern obesity epidemic is mostly a mystery, things like higher caloric food, western diet bad don't tell the whole story. Most likely answers are chemical contaminants in our foods and water i.e. lithium or PFAS chemicals. Interestingly enough both wild animals and lab animals(rats) have been getting fatter over time as well which clearly inva…

TLDR: The modern obesity epidemic is mostly a mystery, things like higher caloric food, western diet bad don't tell the whole story. I think it tells more of the story than contaminants does. A candy bar is packed with calories and not that filling. This didn't exist a long time ago.

The article I linked is very thorough. It covers basic issues like that: "Today the rate of obesity in Italy, France, and Sweden is around 20%. In 1975, there was no country in the world that had an obesity rate higher than 15%.

This wasn’t a steady, gentle trend as food got better, or diets got worse. People had access to plenty of delicious, high-calorie foods back in 1965. Doritos were invented in 1966, Twinkies in 1930, Oreos in 1912, and Coca-Cola all the way back in 1886. So what changed in 1980?"

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#924

Post by nsxwolf »

galangalalgol wrote: post #749
nsxwolf wrote: post #618

Earlier quoted context omitted.

I'm going to try this because I recently fell off the OMAD wagon, and it usually takes me 3 solid days of white-knuckling it to get back to it feeling natural without wanting to eat during the day. Wondering if some plain celery or olive oil can ease the transition.

I'm going to try it with my omad diet because I only remember to take my supplements if I do it in the morning, but some are fat soluble, and the zinc can cause nausea on occasion, but if I get any carbs in the morning I get hungry. Some mct oil or light olive oil seems perfect. The toothpaste thing seems problematic. There are some bland ones, maybe I'll switch.

I don't think toothpaste is a problem for me, maybe because I associate anything minty with medicine instead of food.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#925

Post by EamonnMR »

contravariant wrote: post #240
EamonnMR wrote: post #120

Earlier quoted context omitted.

Doctors are reluctant to prescribe stimulants to their patients for various reasons. Also you don't keep the weight off with those.

You don't necessarily need a stimulant, you can also e.g. short the mitochondria using DNP. Doing so does have some fairly predictable downsides.

Ha! This made me think of DNP too-the rare drug that modifies the O of CICO. But you can't beat thermodynamics.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#926

Post by JeremyNT »

Auracle wrote: post #803
scarmig wrote: post #649

Earlier quoted context omitted.

> It’s so hard to eat healthy, I honestly cannot fathom how people do it. When I started taking semaglutide, I finally understood it. I'd eat a salad... and be full and more than satisfied! I'd look at a muffin right after lunch, and go "eh, better things to do with my time" instead of immediately having an overriding desire to eat eat eat. Before, I could eat half a pizza and still be hungry (way out of what my body…

I'm sorry, but I'm a decently in shape person that tried semaglutide for reasons other than losing weight and I disagree. While I'm sure we all are a bit different satiety wise (and I've found it greatly depends on how much I've been eating overall recently), your experience on the drug is not what the rest of us feel like all the time. It's unfortunately normal for our biology to basically want to shove calories dow…

> Almost all of us work for it. Truth be told, and please hold your downvotes for this, I get a little upset when the rest of you get to have insurance pay ridiculous sums of money for a medication that makes it easier for you than the rest of us, side effects aside, and you think it's simply evening out the playing field.

I don't really think this is a healthy way to look at it.

Yes every day is a struggle for most of us. I've been in the "healthy" BMI for a majority of my adult life, but only just barely. This requires constant effort and work for me. I assume that most "fit" people are similarly fixated on the quest to remain healthy.

But clearly, there's "something" that we have which makes it possible for us to succeed at this, which people who do not succeed lack. I don't begrudge them taking a shortcut, and I don't mind if they never understand my version of the struggle here, because I don't claim to understand theirs.

Fundamentally, we need to understand that our physiology has not evolved in a situation where we are both sedentary and have unlimited, good tasting food at our disposal, and any tools we have to make this situation easier should be embraced.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#927

Post by EamonnMR »

joe_the_user wrote: post #149
EamonnMR wrote: post #108

Earlier quoted context omitted.

If we're going to treat calories as addictive and addiction as a disease rather than a personal failing it should follow that we treat the disease with a drug.

The problem is that we are plausibly looking at the result of a change over the last thirty or fifty year in the quality of what's considered the normal diet, notably normalizing calories through the consumption of sugary drinks but also a variety of other things. This has had the side-effect of an obesity epidemic. Now, what are we doing? * Getting people to stop consuming sugary drinks and other very unhealthy item…

This class of drugs does address the bad diet though, doesn't it?

Anyway, 'getting people to stop' turns out to be impossible for some. The drugs are meant to help with that.

Diet soda and bottled water exist and somehow people still keep choosing sugary drinks. In fact people often have a ready excuse for why they consider diet soda more unhealthy!

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#928

Post by vimota »

fswd wrote: post #379

It appears you can do the same thing with 3g of cinnamon https://pubmed.ncbi.nlm.nih.gov/19158209/ Conclusions: Ingestion of 3 g cinnamon reduced postprandial serum insulin and increased GLP-1 concentrations without significantly affecting blood glucose, GIP, the ghrelin concentration, satiety, or GER in healthy subjects.

Isn't satiety / ghrelin the mechanism (via GLP-1) for weightloss in semaglutide?

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#929

Post by EamonnMR »

thatguy0900 wrote: post #159
EamonnMR wrote: post #108

Earlier quoted context omitted.

If we're going to treat calories as addictive and addiction as a disease rather than a personal failing it should follow that we treat the disease with a drug.

If we assume addictions as a disease then we mostly treat them with regulation. Smoking companies would have loved if we just made a pill that mitigates tar in your lungs instead of all but legislating them into obscurity.

Jury is still out on how food companies will take a situation where people can be prescribed a pill to be less hungry. I imagine they'd be more scared if it was OTC though.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#930

Post by EamonnMR »

hansonkd13 wrote: post #145
EamonnMR wrote: post #108

Earlier quoted context omitted.

If we're going to treat calories as addictive and addiction as a disease rather than a personal failing it should follow that we treat the disease with a drug.

They didn’t say calories are addictive. They clearly said certain foods are addictive. Those foods should be more regulated like cigarettes and companies take more responsibility as a first or at least concurrent step to everyone taking more drugs.

I'm not sure I buy that argument though. The idea that you can squarely blame the obesity epidemic on some foods and not others.

Hell I'd be ok with banning all forms of food advertising and requiring that all foods be blank packages with nothing but the ingredients, nutrition facts, and a short description of how they were prepared. I'd prefer that world on general principle. But I don't think it would fix the obesity epidemic.

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