You really need to suppress appetite rather than avoid hunger.
How many have of us have eaten despite not being hungry?
‘Breakthrough’ obesity drugs that have stunned researchers
141–150 of 1001 posts
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#142At a risk of being ignorant: Isn’t obesity a function of calories intake and calories burn rate? If so, why do we even need a drug for that? What should a possible drug target here? Assuming no changes in behaviour and thus a continued steady daily caloric surplus, would it even work?
These drugs modulate your hormones to reduce appetite and cravings for unhealthy foods. When people lose weight the normal way, their endocrine system sends out a “you are starving, eat” hormone response that is extremely difficult to overcome and success requires 100% compliance for the rest of your life.
Success in adjusting diet does not require '100% compliance for the rest of your life'. It requires serious changes yes, but even frequent slips as part of a largely altered diet won't discount it. This perspective - as well as being factually inaccurate - feeds into shame spirals and negative self efficacy. It's also true that virtuous circles can be built on diet and exercise, replacing the endorphin lift provided by sugar / carbohydrate load; and in the longer term homeostasis can be achieved at a healthier weight. It is difficult, but it's absolutely not as impossible as this comment implies.
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#143At a risk of being ignorant: Isn’t obesity a function of calories intake and calories burn rate? If so, why do we even need a drug for that? What should a possible drug target here? Assuming no changes in behaviour and thus a continued steady daily caloric surplus, would it even work?
"Stop being poor"
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#144Why does this headline from Nature read like a scam advert from Facebook?
Because sometimes you’re dealing with the real article. This isn’t a boner pill made of rhino horn. This has been proven in double blind studies, FDA approved and has changed the lives of thousands of people. This could potentially halt the obesity epidemic, preventing many early deaths and improving the quality of life of countless others. At that point, such headlines are justified. What would you have written inst…
I'm sure it's possible to formulate a headline for this story that doesn't sound like gutter-tier clickbait. Nature must be doing a poor job hiring / directing their editors.
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#145This drug is a net good for society, but we have to fix the root problem. Much of the food we eat is filled with addictive ingredients (sugar, excess fats/oils, etc) that provide little nutritional value but are highly addictive. We’re subsidizing companies that create unhealthy addictive food and subsidizing companies to create drugs to counter the unhealthy addictive food. This is an enormous waste of resources.
If we're going to treat calories as addictive and addiction as a disease rather than a personal failing it should follow that we treat the disease with a drug.
They didn’t say calories are addictive. They clearly said certain foods are addictive. Those foods should be more regulated like cigarettes and companies take more responsibility as a first or at least concurrent step to everyone taking more drugs.
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#146Earlier quoted context omitted.
> I don't want to eat empty carbs, anywhere near as much. Because I feel like they make me feel sick. I did a keto diet obsessively for a while and I still have a psychological revulsion to drinking coke or eating cake even a year later. Those sorts of things are long term wins.
I had the opposite outcome, several months of keto left me avoiding meat and cheese for a long time.
My keto diet was chocolate protein shakes, protein bars, and powdered soups. New Direction it's called. 3 meals, 2 snacks a day. 128 oz of water a day.
It worked great as a way to lose weight. And for people who need to lose weight to prepare for surgery, I still think it's a neat program.
But I was just not equipped to survive returning to normal foods. And stress.
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#147Earlier quoted context omitted.
I mean, if you have perfect bloodwork and a marvel movie body probably not necessary but otherwise yes. Heart disease, hypertension, high cholesterol, colon cancer rates are rising amongst everyone, even thin people. These drugs positively impact indicators of these things in everyone. Longevity makers have been betting on metformin for a long time and these drugs are like a supercharged metformin
I think I will wait for some version that does not cause "strong nausea, extreme fatigue, brain fog, and constipation".
You forgot the key part of "for the first 3 months" the assumption is that they largely tapered off for OP I think. That's an easy trade off for me personally.
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#148Earlier quoted context omitted.
> How much of it was actually the lifestyle changes? That's why the placebo group in the trial also gets the same lifestyle changes. > This apparently works by suppressing appetite, but doesn't cocaine do the same thing? Sure. If they were otherwise identical, that'd be a good point, but they're not. > Constant needle marks from weekly injections might result in more social complications than anything else... My daug…
> Sure. If they were otherwise identical, that'd be a good point, but they're not. You can say the same of opium, heroin, morphine, oxycodone, fentanyl, and Naloxone. Many of which have had i ical trials done and all of which are abused and addictive. I simply don't trust clinical trials by large pharmaceutical companies any longer.
You say that Naloxone is abused and addictive? That is completely wrong. Naloxone has no addictive potential and has no potential for abuse. I think you have it confused with something else.
Ref: https://www.asam.org/docs/default-source/public-policy-state...
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#149This drug is a net good for society, but we have to fix the root problem. Much of the food we eat is filled with addictive ingredients (sugar, excess fats/oils, etc) that provide little nutritional value but are highly addictive. We’re subsidizing companies that create unhealthy addictive food and subsidizing companies to create drugs to counter the unhealthy addictive food. This is an enormous waste of resources.
If we're going to treat calories as addictive and addiction as a disease rather than a personal failing it should follow that we treat the disease with a drug.
The problem is that we are plausibly looking at the result of a change over the last thirty or fifty year in the quality of what's considered the normal diet, notably normalizing calories through the consumption of sugary drinks but also a variety of other things. This has had the side-effect of an obesity epidemic.
Now, what are we doing?
* Getting people to stop consuming sugary drinks and other very unhealthy items (maybe that would require drugs at this point)?
* Or offer people drugs so this side-effect of an unhealthy diet can be avoided?
If we're offer a way to continue a bad diet without this effect, it seems very likely further bad effects will appear X many years from now from a combination of the drugs and the bad diet. Because virtually all drugs taken forever accumulate side-effects over since the body did evolve to process them (these drugs may indeed be needed at times but the point remains).