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‘Breakthrough’ obesity drugs that have stunned researchers

nature.com

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#111

Post by throwaway5959 »

0xB31B1B wrote: post #86
sfusato wrote: post #79

> I believe that everyone, even the skinny folks, should be on GLP1 drugs for the longevity effects. Are you for real? Serious question.

I mean, if you have perfect bloodwork and a marvel movie body probably not necessary but otherwise yes. Heart disease, hypertension, high cholesterol, colon cancer rates are rising amongst everyone, even thin people. These drugs positively impact indicators of these things in everyone. Longevity makers have been betting on metformin for a long time and these drugs are like a supercharged metformin

Are they rising across the board or for certain ranges of BMI/weight?

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#112

Post by gretch »

voisin wrote: post #107
hammock wrote: post #66

Earlier quoted context omitted.

For those less familiar with BMI, each point of BMI for a man is about 7 pounds. So 34-->23 BMI = -77 lbs. 31-->26 BMI = -35 lbs

It depends on height, so how can you say that?

Probably because height is normally distributed and it’s easy to predict someone’s height within a range.

I’d bet a lot of money the person in the story is not 6 foot 5 inches

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#113

Post by djur »

iammjm wrote: post #37
ceejayoz wrote: post #25

Earlier quoted context omitted.

> Isn’t obesity a function of calories intake and calories burn rate? If so, why do we even need a drug for that? Because calorie intake is substantially impacted by things like satiety. As the article's subtitle heavily hints at, "A class of drugs that quash hunger" is beneficial in moving that bit of the equation.

I understand, but appetite/hunger seems to be just a part of the issue. The second part being people (myself included) using food to comfort ourselves. I feel bad -> I seek tasty food to comfort myself, even if I am not hungry. The whole candy-market is built around. How are drugs to address this?

One effect of these drugs appears to be weakening that "comfort -> food" urge. There's some evidence that it also affects similar urges for alcohol.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#114

Post by standardUser »

dmix wrote: post #58
VikingCoder wrote: post #43

I'm on semaglutide. Was on Saxenda, because I couldn't get access to Wegovy at the lowest dosage. But now I'm on Wegovy, for half a week so far. I was retching horribly one night at 2 am, but didn't throw up. I've felt clammy and dizzy a few times. (Possibly hypoglycemic?) I honestly feel like it's changing how I feel about food. I don't want to eat empty carbs, anywhere near as much. Because I feel like they make me…

> I don't want to eat empty carbs, anywhere near as much. Because I feel like they make me feel sick. I did a keto diet obsessively for a while and I still have a psychological revulsion to drinking coke or eating cake even a year later. Those sorts of things are long term wins.

I had the opposite outcome, several months of keto left me avoiding meat and cheese for a long time.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#116

Post by mcculley »

0xB31B1B wrote: post #86
sfusato wrote: post #79

> I believe that everyone, even the skinny folks, should be on GLP1 drugs for the longevity effects. Are you for real? Serious question.

I mean, if you have perfect bloodwork and a marvel movie body probably not necessary but otherwise yes. Heart disease, hypertension, high cholesterol, colon cancer rates are rising amongst everyone, even thin people. These drugs positively impact indicators of these things in everyone. Longevity makers have been betting on metformin for a long time and these drugs are like a supercharged metformin

I think I will wait for some version that does not cause "strong nausea, extreme fatigue, brain fog, and constipation".

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#117

Post by 0xB31B1B »

throwaway5959 wrote: post #111
0xB31B1B wrote: post #86

Earlier quoted context omitted.

I mean, if you have perfect bloodwork and a marvel movie body probably not necessary but otherwise yes. Heart disease, hypertension, high cholesterol, colon cancer rates are rising amongst everyone, even thin people. These drugs positively impact indicators of these things in everyone. Longevity makers have been betting on metformin for a long time and these drugs are like a supercharged metformin

Are they rising across the board or for certain ranges of BMI/weight?

Across the board

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#118

Post by 0xB31B1B »

gretch wrote: post #112
voisin wrote: post #107

Earlier quoted context omitted.

It depends on height, so how can you say that?

Probably because height is normally distributed and it’s easy to predict someone’s height within a range. I’d bet a lot of money the person in the story is not 6 foot 5 inches

I’m 6 4 though, so not far off

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#119

Post by nindalf »

LarryMullins wrote: post #109

Why does this headline from Nature read like a scam advert from Facebook?

Because sometimes you’re dealing with the real article. This isn’t a boner pill made of rhino horn. This has been proven in double blind studies, FDA approved and has changed the lives of thousands of people. This could potentially halt the obesity epidemic, preventing many early deaths and improving the quality of life of countless others.

At that point, such headlines are justified. What would you have written instead? Something lukewarm like “Obesity drugs show efficacy in many patients”?

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#120

Post by EamonnMR »

Beaver117 wrote: post #87

So does this somehow burn fat or does it just lower your appetite? There are many others drugs that lower appetite, and yet we still have an obesity crisis. Why would this one solve it?

Doctors are reluctant to prescribe stimulants to their patients for various reasons. Also you don't keep the weight off with those.
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