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‘Breakthrough’ obesity drugs that have stunned researchers

nature.com

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Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#121

Post by jboy55 »

mcculley wrote: post #116
0xB31B1B wrote: post #86

Earlier quoted context omitted.

I mean, if you have perfect bloodwork and a marvel movie body probably not necessary but otherwise yes. Heart disease, hypertension, high cholesterol, colon cancer rates are rising amongst everyone, even thin people. These drugs positively impact indicators of these things in everyone. Longevity makers have been betting on metformin for a long time and these drugs are like a supercharged metformin

I think I will wait for some version that does not cause "strong nausea, extreme fatigue, brain fog, and constipation".

I take a GLP-1, I do not feel any of these effects unless I eat poorly. I'm not saying these side-effects don't happen, but they aren't guaranteed. Testing has also shown these aren't prevalent in the majority of users.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#122

Post by djur »

jobs_throwaway wrote: post #4

> The results astonished researchers: a weekly injection for almost 16 months, along with some lifestyle changes, reduced body weight by at least 20% in more than one-third of the participants Why would they introduce lifestyle changes alongside the drug? Doesn't that complicate the analysis?

One of the expected benefits of the medication is to make it easier to comply with recommended lifestyle changes. It simplifies the analysis to recommend a specific set of changes rather than letting all of the participants improvise their own diet and exercise changes.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#123

Post by [deleted] »

v4dok wrote: post #55
PuppyTailWags wrote: post #16

Have we actually studied if the weight loss is resulting in better health outcomes for the people in question? Outside of diabetics (there is evidence that significant weight loss can relieve the effects of type 2 diabetes), I would like to know if just weight loss benefits the cardiovascular system, blood pressure, etc. These aren't as intuitive as we'd like, for example, it turns out that low fat diets didn't make…

>it turns out that low fat diets didn't make people less fat This is not a "turns out". Anyone who believed that just having a "low fat" diet will make them leaner, didn't really know how losing fat works. Fat is a macronutrient (and quite useful one) just making it lower tells you absolutely nothing on its own.

[deleted]

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#124

Post by djur »

__blockcipher__ wrote: post #57
Someone1234 wrote: post #18

Earlier quoted context omitted.

> How much of it was actually the lifestyle changes? It would be more interesting if there were no lifestyle changes... The article answers this further down: > Those receiving weekly injections of semaglutide lost, on average, 14.9% of their body weight after 16 months of treatment; those who received a placebo lost 2.4% on average. Per the article still a lot of work to do in this area, but on the face of it this c…

The line you quoted: > Those receiving weekly injections of semaglutide lost, on average, 14.9% of their body weight after 16 months of treatment; those who received a placebo lost 2.4% on average. Doesn't really have anything to do with the question about lifestyle changes. That question basically centers around whether the 14.9% weight loss occurred independent of or as a result of lifestyle changes downstream from…

To the extent that lifestyle changes include "not eating as much", it seems self-evident that the weight loss was the result of lifestyle changes. A drug that makes it easier to stick with a diet is a huge deal!

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#125

Post by watwut »

0xB31B1B wrote: post #86
sfusato wrote: post #79

> I believe that everyone, even the skinny folks, should be on GLP1 drugs for the longevity effects. Are you for real? Serious question.

I mean, if you have perfect bloodwork and a marvel movie body probably not necessary but otherwise yes. Heart disease, hypertension, high cholesterol, colon cancer rates are rising amongst everyone, even thin people. These drugs positively impact indicators of these things in everyone. Longevity makers have been betting on metformin for a long time and these drugs are like a supercharged metformin

I mean yes, the obesity is actually not the only health issue in existence. Your weight and your health are two different somewhat related variables.

But so, the idea that everyone should take drug designed to make you thin by making you not feel hunge including thin people is scary.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#126

Post by acuozzo »

Beaver117 wrote: post #87

So does this somehow burn fat or does it just lower your appetite? There are many others drugs that lower appetite, and yet we still have an obesity crisis. Why would this one solve it?

> There are many others drugs that lower appetite, and yet we still have an obesity crisis.

Which ones are prescribed in the US, on label, to treat obesity?

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#128

Post by drowsspa »

dmix wrote: post #58
VikingCoder wrote: post #43

I'm on semaglutide. Was on Saxenda, because I couldn't get access to Wegovy at the lowest dosage. But now I'm on Wegovy, for half a week so far. I was retching horribly one night at 2 am, but didn't throw up. I've felt clammy and dizzy a few times. (Possibly hypoglycemic?) I honestly feel like it's changing how I feel about food. I don't want to eat empty carbs, anywhere near as much. Because I feel like they make me…

> I don't want to eat empty carbs, anywhere near as much. Because I feel like they make me feel sick. I did a keto diet obsessively for a while and I still have a psychological revulsion to drinking coke or eating cake even a year later. Those sorts of things are long term wins.

I wish I got to this stage where people lose their cravings. While I'm at home I can control my diet pretty well, but as soon as there's junk food in front of me I look like a pig. And I've lost like 30 pounds, to put it into perspective.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#129

Post by jboy55 »

Communitivity wrote: post #42

I think it's awesome that there's a new use for these drugs. However, obesity kills slowly, when it kills. Diabetes and Chronic Kidney Disease kill more quickly if not under control. These drugs keep diabetes under control..and diabetics like my wife are unable to get their meds because people are buying these off the shelf to lose weight. I don't pretend to know the solution, but I do think drug availability should…

> Diabetes and Chronic Kidney Disease kill more quickly if not under control. These drugs keep diabetes under control..and diabetics like my wife are unable to get their meds because people are buying these off the shelf to lose weight.

This seems to be a short term problem, and the solution is to simply make more of the drug to match demand.

Re: ‘Breakthrough’ obesity drugs that have stunned researchers

#130

Post by djur »

smith7018 wrote: post #35
Izkata wrote: post #8

> They described the details of an investigation of a promising anti-obesity medication in teenagers, a group that is notoriously resistant to such treatment. The results astonished researchers: a weekly injection for almost 16 months, along with some lifestyle changes, reduced body weight by at least 20% in more than one-third of the participants1. Previous studies2,3 had shown that the drug, semaglutide, was just a…

Cocaine does the same thing but it only lasts ~20 minutes. Ozempic is a once a week injection that curbs appetite and makes the user feel fuller faster. It also comes in a pen (like an epipen) and is injected into fat stores so the user probably won't have "track marks."

Also, these medications aren't stimulants, which is really important for people who might be at higher risk for heart issues.
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