Gosh, no - strongly recommending not doing this. (The lying part)
Lying is one of the worst things you can do, it usually speaks to an issue with integrity, a concern that comes before almost all of them even intelligence, education, aptitude, skills.
Learn the skill of polite deferral, of saying things without saying them, diverting or embellishing a bit - and then only if it's an issue not relevant to the job.
If someone in an interview asks you your 'political orientation' (which obviously they shouldn't do and it would raise a big red flag anyhow - but just as an example) you do not have to be candid, but don't lie. You can say "I have a variety of opinions, I try to keep an open mind" - so long as you are comfortable with it and it's true. You have not lied, but not fully answered the question because it's none of their business.
I also think the OP here has misinterpreted 'transparency and candor'.
Engineers who 'over share' are a bit annoying but then again, you don't have to read their posts - but this is not the issue.
The 'issue' here is the absolutely truthful information that is 'just too much' for an interview setting.
Everyone needs to be honest and candid but not transparent like you're talking to the IRS or your accountant.
Suppose they ask you why you might want to work at the company, and you don't really feel hugely inspired, well, instead of saying literally that, you can find at least something interesting about the situation and allude to it. There's something interesting about every situation. And of course, if it's truly a bad situation just say that politely and assume you won't be working there.
It's ok to ask 'Elephant in the Room' questions especially if they are asked politely, if they can't handle that you don't want to work there.
It's ok to be turned away for something arbitrary or mundane (or any other reason) there will be other opportunities.
Getting turned down can make you very cynical and brings out our worst, even conspiratorial tendencies so try to stay grounded and keep your head on straight, don't be sucked into the vortex of weirdness and 'ultra competitive civility' of getting job shenanigans, it's not real, it's a big of a game, recognise it a such.
Kind of like telling people to 'don't be nervous' on a date, what I'm about to write is super glib but I think it's true: stay true to your basic values and identity and I think it will be easier to be more relaxed and authentic in interviews. The 'game' will pull you towards negative behaviours I have found it's a lot easier not to do them if you literally just decide that you are not going to do so for reasons of morality or values or whatever.