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What causes Alzheimer's? Scientists are rethinking the answer

quantamagazine.org

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Re: What causes Alzheimer's? Scientists are rethinking the answer

#151

Post by dontwearitout »

bitexploder wrote: post #138
ericmcer wrote: post #72

Earlier quoted context omitted.

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

Define: eating right. It’s really hard. Sleeping and exercise are easier.

Individual needs vary, but the Mediterranean diet is a great place to start: https://en.wikipedia.org/wiki/Mediterranean_diet

> The Mediterranean diet is associated with a reduction in all-cause mortality in observational studies. There is evidence that the Mediterranean diet lowers the risk of heart disease and early death. The American Heart Association and American Diabetes Association recommend the Mediterranean diet as a healthy dietary pattern that may reduce the risk of cardiovascular diseases and type 2 diabetes, respectively.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#152

Post by jstgord »

matwood wrote: post #129
nordsieck wrote: post #99

Earlier quoted context omitted.

> You don’t need a gym, those are just excuses. Sort of. Physical fitness for good health has 2 components: aerobic fitness and strength. You can improve your aerobic fitness and your upper body strength at home (rings and/or handstand pushups are enough for all but the most advanced strength athletes). Core/lower body strength is another matter entirely. People tend to quickly progress to 1x body weight squats and d…

If you want to go really cheap, buy a kettlebell. When that becomes too easy, buy a heavier one. Unless the goal is actual powerlifting, buying a kettlebell every time you need a heavier one will carry a person a very long ways. If a person has more money and the space, they can do the same thing with dumbbells. It's really not complicated, but people make it so.

... cheaper still, Im experimenting with two 3-litre plastic milk containers, filled with water.

[ be sure to a) check for leakages regularly and b) do arm curls well away from electric outlets, just in case ]

Re: What causes Alzheimer's? Scientists are rethinking the answer

#153

Post by eloff »

Andrex wrote: post #128
ericmcer wrote: post #72

Earlier quoted context omitted.

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

Maybe the expectation that technology will solve all our problems has been and will always be false. Techno-utopianism is a shallow dream.

Says the guy hypocritically from his smartphone.

Technology has solved so many problems. It's also created new ones. But we're way better off, there's no question of that.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#154

Post by 90d »

ericmcer wrote: post #72
personalityson wrote: post #68

"Scientists researching possible candidates for treating Alzheimer's disease found exercise outperformed all tested drugs for the ability to reverse dysregulated gene expression." https://www.nature.com/articles/s41598-022-22179-z "High fitness in middle age reduces the chance of dementia by ninety percent" https://www.ergo-log.com/high-fitness-in-middle-age-reduces-...

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

The only thing that is humorous and disheartening is that your outlook is shared by the majority and for this, we are fucked. The inability of large corporations to best what is available to EVERY PERSON, for FREE, is a BLESSING. All these companies do is add layers of complexity or outright push a worse product and rely on changing public opinion or how info is perceived for sales. This is capitalism's kiss of death. Their goal is not healing, their goal is removal of symptoms where you will be held in perpetual subsistence. And we should never let that be forgotten.

On a macro level if you want to improve your health : Less processed foods, less synthetic materials, less pharmaceuticals, less time sitting and indoors. Less alcohol, less weed, Less involvement from these "professionals" all across the board. Less, less, less. Wow, isn't that weird?

For those who will comment for arguments sake, I would rather you provide examples of the sitting President promoting overall good health practices (read: FREE) rather than his usual gaslighting the public into taking an untested pharmaceutical product.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#155

Post by Aperocky »

ericmcer wrote: post #72
personalityson wrote: post #68

"Scientists researching possible candidates for treating Alzheimer's disease found exercise outperformed all tested drugs for the ability to reverse dysregulated gene expression." https://www.nature.com/articles/s41598-022-22179-z "High fitness in middle age reduces the chance of dementia by ninety percent" https://www.ergo-log.com/high-fitness-in-middle-age-reduces-...

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

As long as you stay biological that's always going to be the case.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#156

Post by lofaszvanitt »

kyaghmour wrote: post #12

As someone who has a close relative diagnosed with this disease, I'm always on the lookout for new information. So this is interesting. One area I'm particularly interested in is the correlation to diabetes. It's a factor that I found being mentioned here and there in some references. In the immediate case that interests me, there's a 20+ year history of type 2 diabetes and a recent scan showed severe bilateral hypoc…

Yudkin wrote the book about sugars Pure, White and Deadly in 1972.

EMPHASIS: 1972! 50 years ago.

And processed foods is everywhere. And people are wondering why we have diabetes and possibly brain diabetes that is Alzheimer's.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#157

Post by Aperocky »

wwwtyro wrote: post #4

I'm fine with most researchers pursuing a particular direction, but I get concerned when incentives align that provide a significant pressure for them to research what they wouldn't naturally want to research. It seems like there should be a distribution of research directions, not everyone in lockstep. It's hard to gauge from the outside to what degree that is happening in our research institutions today.

This is what it is: Academic Ponzi Scheme.

It just have a longer life than normal ponzi schemes, but ends up in the same way in about 20-40 years.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#158

Post by xwdv »

angrais wrote: post #139
literalAardvark wrote: post #123

Earlier quoted context omitted.

For staving off disease you just need decent fitness, not 3x bw. You can absolutely get to 2x bw squats from home with nothing but a chair as gear.

How can you get 2x bw squats at home? What are you squatting? Your fridge and oven?

Pistol Squats.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#159

Post by marricks »

eloff wrote: post #153
Andrex wrote: post #128

Earlier quoted context omitted.

Maybe the expectation that technology will solve all our problems has been and will always be false. Techno-utopianism is a shallow dream.

Says the guy hypocritically from his smartphone. Technology has solved so many problems. It's also created new ones. But we're way better off, there's no question of that.

> Says the guy hypocritically from his smartphone.

How is it hypocritical? Opposed to any other times in human history you can’t give up on society and live a peaceful life in a community.

We’re born into it along with all our families and friends. Telling someone to go off and live in the woods is a life of solitude and probably harsh run ins with the law.

There is no choice nowadays and saying “ha but you live in society so you can’t critique it” is a willful ignorance.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#160

Post by 90d »

im3w1l wrote: post #142
burnerburnito wrote: post #88

Earlier quoted context omitted.

Modern medical tech and practices are keeping us alive healthier and longer. Being disheartened by the fact you still need to eat right, sleep, etc. is like being disheartened that you still need to do regular maintenance on your car and treat it well. The simple fact is that if you sabotage your body, you'll have more issues cropping up sooner and with greater severity, and if you keep it strong all that medical adv…

The thing with eating and sleeping right etc is that we know the limits of it: it can keep you alive into your 90's at best, and more realistically into your 80's. Technology on the other hand is completely uncapped. A pill that keeps a degenerate bum alive into the 80's might be really hard to achieve, but the kicker is that once you do, it's just another step or two to keeping him alive until 200.

The majority of us will be long dead before then, even moreso if your random sci-fi pill is released into the wild ( never would be ).
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