Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

What causes Alzheimer's? Scientists are rethinking the answer

quantamagazine.org

Post reply on HN
Print view View original

131–140 of 243 posts

Re: What causes Alzheimer's? Scientists are rethinking the answer

#131

Post by gscott »

ericmcer wrote: post #72
personalityson wrote: post #68

"Scientists researching possible candidates for treating Alzheimer's disease found exercise outperformed all tested drugs for the ability to reverse dysregulated gene expression." https://www.nature.com/articles/s41598-022-22179-z "High fitness in middle age reduces the chance of dementia by ninety percent" https://www.ergo-log.com/high-fitness-in-middle-age-reduces-...

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

Maybe you are not out of luck yet!

https://scitechdaily.com/new-pill-replicates-exercise-and-st...

Re: What causes Alzheimer's? Scientists are rethinking the answer

#132

Post by wutheringh »

l2silver wrote: post #103
wutheringh wrote: post #85

Earlier quoted context omitted.

No one talks about it because it’s too ridiculous to be taken seriously by anyone with credentials

What's ridiculous about it?

You're right, do you want to march on over with me to Columbia and let everyone there know that Dale Bredesen actually got it right and his delusional ideas have been overlooked by the entire scientific community?

Re: What causes Alzheimer's? Scientists are rethinking the answer

#133

Post by Teandw »

torben-friis wrote: post #29

Has anyone noticed that Alzheimer’s research tend to hit the front page much more than other medical news? I’ve been wondering why for a while.

I think it's because Alzheimer's essentially ends in people you know, turning into a person that you don't know. They basically turn into someone else.

Because that has a more direct emotional affect on those around them, it gives people a stronger desire to want to eradicate it.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#134

Post by jmcgough »

ericmcer wrote: post #72
personalityson wrote: post #68

"Scientists researching possible candidates for treating Alzheimer's disease found exercise outperformed all tested drugs for the ability to reverse dysregulated gene expression." https://www.nature.com/articles/s41598-022-22179-z "High fitness in middle age reduces the chance of dementia by ninety percent" https://www.ergo-log.com/high-fitness-in-middle-age-reduces-...

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

This is a single study with a limited sample. A meta-analysis puts it at about 30-40%.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#135

Post by snshn »

TheSpiceIsLife wrote: post #120
snshn wrote: post #57

Earlier quoted context omitted.

I think it's extremely likely it's caused by something either unknown or previously considered to be safe for humans. Would be nice to study groups of people and see their rates of this illness. Multi-group elimination diet, with HTMA and blood and bone marrow tested for presence of metals, oxidants, etc.

I'd like to assume epidemiologists are all over this?

I think the main problem is that there's no money in saving old people. The current system we have is built around what can benefit the pharmaceutical industry the most, on a long-term basis. Old folks die too soon and often don't have much money to begin with, so sadly it's likely not high on the priority list.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#136

Post by Teandw »

l2silver wrote: post #103
wutheringh wrote: post #85

Earlier quoted context omitted.

No one talks about it because it’s too ridiculous to be taken seriously by anyone with credentials

What's ridiculous about it?

He's never actually given ANY evidence to prove what he's suggesting. He's only shown clinical cases which are basically "these people followed my advice and got better" - Which isn't exactly scientific.

It's akin to me saying that if you eat one cheeseburger every day for your whole life, you'll not get dementia. Then when you don't get dementia in the next 10 years, say that it shows what I'm saying must have had some validity behind it.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#137

Post by UncombedCoconut »

mikenew wrote: post #130

There's a lot of articles recently on how we're "rethinking" Alzheimer's, and what is utterly baffling to me is the way none of them seem to mention that it has recently come to light that much of the foundational research on Alzheimer's was falsified: https://www.science.org/content/article/potential-fabricatio...

Great news: this article does discuss it. It links to that exact Science paper.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#138

Post by bitexploder »

ericmcer wrote: post #72
personalityson wrote: post #68

"Scientists researching possible candidates for treating Alzheimer's disease found exercise outperformed all tested drugs for the ability to reverse dysregulated gene expression." https://www.nature.com/articles/s41598-022-22179-z "High fitness in middle age reduces the chance of dementia by ninety percent" https://www.ergo-log.com/high-fitness-in-middle-age-reduces-...

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

Define: eating right. It’s really hard. Sleeping and exercise are easier.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#139

Post by angrais »

literalAardvark wrote: post #123
nordsieck wrote: post #99

Earlier quoted context omitted.

> You don’t need a gym, those are just excuses. Sort of. Physical fitness for good health has 2 components: aerobic fitness and strength. You can improve your aerobic fitness and your upper body strength at home (rings and/or handstand pushups are enough for all but the most advanced strength athletes). Core/lower body strength is another matter entirely. People tend to quickly progress to 1x body weight squats and d…

For staving off disease you just need decent fitness, not 3x bw. You can absolutely get to 2x bw squats from home with nothing but a chair as gear.

How can you get 2x bw squats at home? What are you squatting? Your fridge and oven?

Re: What causes Alzheimer's? Scientists are rethinking the answer

#140

Post by angrais »

cactusplant7374 wrote: post #96
6nf wrote: post #62

Earlier quoted context omitted.

Why do you consume a lot of sugar?

I like candy. I eat 500 to 1000 calories a day usually. I have a pretty demanding workout routine and that helps absorb the energy. In the past I have eaten a fruitarian diet to fuel my workouts. And sometimes I consumed pure sugar.

I'm confused. Do you eat 500-1k calories of sugar a day or calories overall?
Post reply on HN