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What causes Alzheimer's? Scientists are rethinking the answer

quantamagazine.org

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Re: What causes Alzheimer's? Scientists are rethinking the answer

#91

Post by hgomersall »

adamredwoods wrote: post #76
ericmcer wrote: post #72

Earlier quoted context omitted.

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

I wish gyms were less expensive, and had places, even a table perhaps, that kids and tweens could use. It would make exercise more accessible for me and my lifestyle. In university, I had an indoor track I could use, it was fantastic and had plenty of room for families and people exercising.

No, we need cities and towns that are designed around active transport. Exercise should not be a "thing you do", it should just be part of life. If you want to "do exercise" it needs to be in addition to the normal every day base level of exercise everyone gets for free.

That said, you don't need to wait to be given those opportunities. Look for every opportunity for unnecessary expenditure of energy - you'll find there are plenty.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#92

Post by api »

ericmcer wrote: post #72
personalityson wrote: post #68

"Scientists researching possible candidates for treating Alzheimer's disease found exercise outperformed all tested drugs for the ability to reverse dysregulated gene expression." https://www.nature.com/articles/s41598-022-22179-z "High fitness in middle age reduces the chance of dementia by ninety percent" https://www.ergo-log.com/high-fitness-in-middle-age-reduces-...

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

Humans are a very long lived species already at least when compared to most other large high metabolism mammals. That means evolution already did a lot of optimization for longevity, possibly driven by the high value of grandparents in child rearing and passing on valuable knowledge.

This is also why lots of mouse longevity research doesn’t translate well to humans. Mice are not a particularly longevity optimized mammal so it means there is more low hanging fruit there.

For us all the low hanging fruit is likely picked.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#94

Post by t-writescode »

ericmcer wrote: post #72
personalityson wrote: post #68

"Scientists researching possible candidates for treating Alzheimer's disease found exercise outperformed all tested drugs for the ability to reverse dysregulated gene expression." https://www.nature.com/articles/s41598-022-22179-z "High fitness in middle age reduces the chance of dementia by ninety percent" https://www.ergo-log.com/high-fitness-in-middle-age-reduces-...

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

If we prioritized walkable cities and outdoor time in our lives, would that be so bad?

I find it American culture and decades of bad city planning to be a greater harm for living healthy than most other sources of not living healthy.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#95

Post by jleyank »

Remember they need new ideas and then they need animal models with which they can test these new ideas. They had one, they had drug candidates that satisfied the model and yet nothing happened. We’ve just seen the various tries run down and smell the smoke of billions of dollars burning to ash.

It’s research not engineering and we can’t experiment on people. Huge unmet market need will keep companies trying.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#96

Post by cactusplant7374 »

6nf wrote: post #62
cactusplant7374 wrote: post #37

Earlier quoted context omitted.

I consume a lot of sugar. I’m not diabetic or pre diabetic. I would suspect underlying inflammation leads to some nasty effects. The same for heart disease.

Why do you consume a lot of sugar?

I like candy. I eat 500 to 1000 calories a day usually. I have a pretty demanding workout routine and that helps absorb the energy.

In the past I have eaten a fruitarian diet to fuel my workouts. And sometimes I consumed pure sugar.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#97

Post by cactusplant7374 »

tejtm wrote: post #84
6nf wrote: post #62

Earlier quoted context omitted.

Why do you consume a lot of sugar?

evolved preference v.s. targeted marketing v.s. agribusiness subsidies ... just kidding they all work together

I think I like the buzz. I go hard on hot sauce too. The endorphin rush from hot sauce is amazing. I bring a fresh bottle with me every time I go to a new restaurant. Sometimes when I leave it’s empty.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#98

Post by fma »

adamredwoods wrote: post #76
ericmcer wrote: post #72

Earlier quoted context omitted.

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

I wish gyms were less expensive, and had places, even a table perhaps, that kids and tweens could use. It would make exercise more accessible for me and my lifestyle. In university, I had an indoor track I could use, it was fantastic and had plenty of room for families and people exercising.

Planet Fitness is like $10 a month and usually 24/7. I'm sure someone will criticize planet fitness because it doesn't have x,y,z...but I don't think you can get better value for an average person.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#99

Post by nordsieck »

xwdv wrote: post #82
adamredwoods wrote: post #76

Earlier quoted context omitted.

I wish gyms were less expensive, and had places, even a table perhaps, that kids and tweens could use. It would make exercise more accessible for me and my lifestyle. In university, I had an indoor track I could use, it was fantastic and had plenty of room for families and people exercising.

You don’t need a gym, those are just excuses. You can do a lot right at home, and more frequently as you don’t need to go all the way to the gym every time.

> You don’t need a gym, those are just excuses.

Sort of.

Physical fitness for good health has 2 components: aerobic fitness and strength. You can improve your aerobic fitness and your upper body strength at home (rings and/or handstand pushups are enough for all but the most advanced strength athletes).

Core/lower body strength is another matter entirely. People tend to quickly progress to 1x body weight squats and deadlifts. And someone who is more advanced will probably be in the 2x-3.5x range. Without access to serious weight, lower body training is usually pretty ineffective, strength wise.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#100

Post by cactusplant7374 »

simmerup wrote: post #42
cactusplant7374 wrote: post #37

Earlier quoted context omitted.

I consume a lot of sugar. I’m not diabetic or pre diabetic. I would suspect underlying inflammation leads to some nasty effects. The same for heart disease.

Are you balding?

No.
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