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What causes Alzheimer's? Scientists are rethinking the answer

quantamagazine.org

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Re: What causes Alzheimer's? Scientists are rethinking the answer

#81

Post by xwdv »

ericmcer wrote: post #72
personalityson wrote: post #68

"Scientists researching possible candidates for treating Alzheimer's disease found exercise outperformed all tested drugs for the ability to reverse dysregulated gene expression." https://www.nature.com/articles/s41598-022-22179-z "High fitness in middle age reduces the chance of dementia by ninety percent" https://www.ergo-log.com/high-fitness-in-middle-age-reduces-...

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

That should be encouraging, not disheartening. The best methods for keeping healthy just involve easy simple things anyone could do for free everyday. That’s better than any dependence on shitty expensive drugs.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#82

Post by xwdv »

adamredwoods wrote: post #76
ericmcer wrote: post #72

Earlier quoted context omitted.

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

I wish gyms were less expensive, and had places, even a table perhaps, that kids and tweens could use. It would make exercise more accessible for me and my lifestyle. In university, I had an indoor track I could use, it was fantastic and had plenty of room for families and people exercising.

You don’t need a gym, those are just excuses. You can do a lot right at home, and more frequently as you don’t need to go all the way to the gym every time.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#83

Post by hnuser847 »

adamredwoods wrote: post #76
ericmcer wrote: post #72

Earlier quoted context omitted.

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

I wish gyms were less expensive, and had places, even a table perhaps, that kids and tweens could use. It would make exercise more accessible for me and my lifestyle. In university, I had an indoor track I could use, it was fantastic and had plenty of room for families and people exercising.

The big corporate gyms are dirt cheap and typically have onsite daycare for a small fee. My wife and I pay $55 a month for a family membership at LA fitness, and daycare is $5 per visit or $15 extra per month. No indoor track, though.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#84

Post by tejtm »

6nf wrote: post #62
cactusplant7374 wrote: post #37

Earlier quoted context omitted.

I consume a lot of sugar. I’m not diabetic or pre diabetic. I would suspect underlying inflammation leads to some nasty effects. The same for heart disease.

Why do you consume a lot of sugar?

evolved preference v.s. targeted marketing v.s. agribusiness subsidies

... just kidding they all work together

Re: What causes Alzheimer's? Scientists are rethinking the answer

#85

Post by wutheringh »

l2silver wrote: post #38

Did anyone read "The end of Alzheimers" by Dr. Bredesen? In the book he claims to have the cure, but no one has really talked about his approach. Was it debunked? I'm confused.

No one talks about it because it’s too ridiculous to be taken seriously by anyone with credentials

Re: What causes Alzheimer's? Scientists are rethinking the answer

#86

Post by nradov »

kyaghmour wrote: post #12

As someone who has a close relative diagnosed with this disease, I'm always on the lookout for new information. So this is interesting. One area I'm particularly interested in is the correlation to diabetes. It's a factor that I found being mentioned here and there in some references. In the immediate case that interests me, there's a 20+ year history of type 2 diabetes and a recent scan showed severe bilateral hypoc…

Research has shown that many type-2 diabetes patients can put their disease into remission, or at least reduce the need for exogenous insulin, through nutritional ketosis.

https://www.virtahealth.com/research

It's unknown whether that would reduce the risk of Alzheimer's disease. Worth a try anyways.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#87

Post by r930 »

kyaghmour wrote: post #12

As someone who has a close relative diagnosed with this disease, I'm always on the lookout for new information. So this is interesting. One area I'm particularly interested in is the correlation to diabetes. It's a factor that I found being mentioned here and there in some references. In the immediate case that interests me, there's a 20+ year history of type 2 diabetes and a recent scan showed severe bilateral hypoc…

My speculation, as with others, is that Alzheimer's disease (as well as many other slow progressing diseases) is just a metabolic disease, inline with the "type 3 diabetes" comments.

Look into supporting mitochondria health [0] and the glymphatic system [1]: good diet (with fasting), light to moderate exercise, sleep and wake at the same time each day for circadian rhythm training, reduce unnecessary stress.

Once the basics have been implemented, some supplements could help to further support cell function if needed: Longevity supplements that Dr David Sinclair takes [2], boosting cellular glutathione stores, with NACET, glycine, selenium [3]

[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684129/ [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/ [2] https://novoslabs.com/best-anti-aging-supplements-that-harva... [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889054/

Re: What causes Alzheimer's? Scientists are rethinking the answer

#88

Post by burnerburnito »

ericmcer wrote: post #72
personalityson wrote: post #68

"Scientists researching possible candidates for treating Alzheimer's disease found exercise outperformed all tested drugs for the ability to reverse dysregulated gene expression." https://www.nature.com/articles/s41598-022-22179-z "High fitness in middle age reduces the chance of dementia by ninety percent" https://www.ergo-log.com/high-fitness-in-middle-age-reduces-...

I hate this because I want to believe technology and AI and will result in modern medicine where everyone has long healthy lives. The reality that just eating right, sleeping and exercising is still our best health advice is humorous and disheartening.

Modern medical tech and practices are keeping us alive healthier and longer. Being disheartened by the fact you still need to eat right, sleep, etc. is like being disheartened that you still need to do regular maintenance on your car and treat it well.

The simple fact is that if you sabotage your body, you'll have more issues cropping up sooner and with greater severity, and if you keep it strong all that medical advancement actually has an opportunity to help you in the cases where your body can't help itself. It doesn't discredit medical advancement, only reminds us that many people's lifestyles can often be more destructive than we realize.

Re: What causes Alzheimer's? Scientists are rethinking the answer

#89

Post by [deleted] »

steve_adams_86 wrote: post #69
personalityson wrote: post #68

"Scientists researching possible candidates for treating Alzheimer's disease found exercise outperformed all tested drugs for the ability to reverse dysregulated gene expression." https://www.nature.com/articles/s41598-022-22179-z "High fitness in middle age reduces the chance of dementia by ninety percent" https://www.ergo-log.com/high-fitness-in-middle-age-reduces-...

Not to be pedantic, but the number appears to be (up to) 88%, and the study involved women only. Incredible results but I think the specifics are worth using when they’re available. Also, there is no cause and effect here, though vascular origin dementia as noted seems almost certainly to be reduced by better cardiovascular fitness, as are many other vascular issues. Having said that, vascular and arterial lining dam…

[deleted]

Re: What causes Alzheimer's? Scientists are rethinking the answer

#90

Post by nradov »

thevulcanlogic wrote: post #80
lucidrains wrote: post #17

Earlier quoted context omitted.

in some medical circles, alzheimers is referred to as "type 3 diabetes"

so why don't Alzheimer's patient take diabetes medication and problem solved?

Certain medications such as metformin and SGLT2 inhibitors can be fairly effective in treating type-2 diabetes, but they don't really correct the underlying pathology. Lifestyle changes including increased exercise and greatly reducing carbohydrate consumption will do more over the long run and should be the first line therapy for patients with metabolic syndrome or pre-diabetes. Of course that won't be sufficient for some patients, and others are unwilling to make the necessary lifestyle changes.
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