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Aerobic exercise can reduce the risk of metastatic cancer in mice: study

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Re: Aerobic exercise can reduce the risk of metastatic cancer in mice: study

#71

Post by racking7 »

kritiko wrote: post #48
marricks wrote: post #41

Pretty great thing to read coming back from a tempo run! I just go into it this year, and I'd like to say, it's more fun than I thought. Every aspect. If you get a heart rate monitor and dive into what you're doing even difficult high intensity runs are enjoyable. It's all about expectations and if you go into it thinking - "I'm going to run at 75% of my max heart rate" you know you're going to be winded, but at the…

Have you actually tested your max heart rate? I work out with a HRM for Zone 2, but I'm just going off of Polar's zones. From what I understand going more in depth requires either maxing out your HR (Steve House describes how you can do this in Training for the New Alpinism - basically sprinting uphill until you collapse, seems really unpleasant) or doing lactate testing in a lab.

You should check out doing an Aerobic Threshold (AeT) test and an Anaerobic Threshold (AnT) test. I believe there are details on the Uphill Athlete site. But you should absolutely determine your AeT if you’re trying to base build in zone 2 (180-age is a good place to start, but it is likely lower). AnT is useful as well for higher zone training. It’s a more demanding test than AeT but will give you a more practical upper bound for speed workouts than max HR.

Re: Aerobic exercise can reduce the risk of metastatic cancer in mice: study

#72

Post by aliqot »

ck2 wrote: post #12

I know of so many life-long runners that have gotten or even died from cancer. So not sure what to say otherwise but this paper is wrong and needs to be challanged.

anybody who lives long enough succumbs to cancer. anybody. not one exception. you can have the fittest heart and safest lifestyle, but your cells will always replicate with less and less accuracy, the sun and other sources of genetic damage will keep inundating you.

Re: Aerobic exercise can reduce the risk of metastatic cancer in mice: study

#73

Post by canucker2016 »

dilyevsky wrote: post #35
imnotlost wrote: post #6

Earlier quoted context omitted.

For 80-85% of maximum pulse rate... If your lungs are burning and you're about to collapse after 30 seconds of activity the intensity is about right. Do 30 seconds high intensity, then 90 seconds low intensity (don't sit down or stand still), repeat 8 times. Rowing and sprinting works really well.

If you’re training regularly 80-85% is nowhere near where your lungs burn - that’s like below 165bpm for most people

80-85% max heart rate is tempo pace - people suggest it's around the pace that one can hold for one hour

Re: Aerobic exercise can reduce the risk of metastatic cancer in mice: study

#74

Post by ferrumfist »

pimterry wrote: post #33
twawaaay wrote: post #8

I am layman but can somebody explain this? Even if blood sugar level dips during the exercise it comes right back immediately after. Even if you exercise a lot, for majority of the day your blood sugar level should be nominal because nobody can exercise at the effort needed to dip your sugar for very long. So does this mean cancer cells are so hungry for sugar that they can't survive even a short term dip in sugar av…

> So does this mean cancer cells are so hungry for sugar that they can't survive even a short term dip in sugar availability? It's not a short-term dip, according to the article: > "Examining the cells of these organs, we found a rise in the number of glucose receptors during high-intensity aerobic activity - increasing glucose intake and turning the organs into effective energy-consumption machines, very much like t…

I'm no doctor, but it makes sense why exercise is also prescribed for countering diabetes in that case. If organs and muscles are "hungrier" for glucose when routinely exercising it seems like it would regulate blood sugar levels.

Re: Aerobic exercise can reduce the risk of metastatic cancer in mice: study

#75

Post by jamesgill »

"...Intense aerobic exercise increases the glucose (sugar) consumption of internal organs, thereby reducing the availability of energy to the tumor."

Interestingly, this is a key part of the medical argument for low-carbohydrate diets--that most human diseases are metabolic ones, including cancer, and that modern human diets are at the root of them. One discussion: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375425/

Re: Aerobic exercise can reduce the risk of metastatic cancer in mice: study

#76

Post by marricks »

jfoutz wrote: post #67
marricks wrote: post #41

Pretty great thing to read coming back from a tempo run! I just go into it this year, and I'd like to say, it's more fun than I thought. Every aspect. If you get a heart rate monitor and dive into what you're doing even difficult high intensity runs are enjoyable. It's all about expectations and if you go into it thinking - "I'm going to run at 75% of my max heart rate" you know you're going to be winded, but at the…

I have a few opinions about distance running. A coworker explained it has a way of turning down the volume on the rest of your perception. Something about running 10 miles makes other problems less anxiety inducing. They're still important, they're just not, like, scary. If you consider distance running, get good shoes. go to the kind of place that puts you in shoes, and videos you running on a treadmill. Some people…

I completely agree on all of this. I had an on again off again relationship with running before this year and it’s because… I ran in the same shoes for 8 years and I’d stop when my hip or knee felt off. Got new shoes this year and I’ve done more running than I ever had with no issues. Shoes only last 250-500 miles!

Definitely agree with pain as well, there is good pain and bad pain and tendon pain is never good pain.

Re: Aerobic exercise can reduce the risk of metastatic cancer in mice: study

#77

Post by nanomonkey »

mrleinad wrote: post #11
imnotlost wrote: post #6

Earlier quoted context omitted.

For 80-85% of maximum pulse rate... If your lungs are burning and you're about to collapse after 30 seconds of activity the intensity is about right. Do 30 seconds high intensity, then 90 seconds low intensity (don't sit down or stand still), repeat 8 times. Rowing and sprinting works really well.

Would swimming work as well? I can see myself doing some laps really fast that will leave me panting by the poolside after 50 mts.

I wouldn't suggest using swimming to calculate your maximum heart rate, as you have less control over when you breath. Also, you don't want to be out of breath anywhere near water, the potential for passing out and drowning is too great.

Just put on your heart rate monitor, get warmed up, and then sprint as fast as you can until you collapse, most easily done by sprinting uphill. Note your maximum heart rate recorded.

Re: Aerobic exercise can reduce the risk of metastatic cancer in mice: study

#78

Post by m463 »

rollo wrote: post #47
imnotlost wrote: post #6

Earlier quoted context omitted.

For 80-85% of maximum pulse rate... If your lungs are burning and you're about to collapse after 30 seconds of activity the intensity is about right. Do 30 seconds high intensity, then 90 seconds low intensity (don't sit down or stand still), repeat 8 times. Rowing and sprinting works really well.

That doesn't sound right. Even 95% of max heart rate is sustainable for a long, long time. Intervals one can only sustain for 30s are way above VO2max intensity deep in the anaerobic zone. Heart rate pretty much maxes out on those.

It's possible you haven't calculated actual max heart rate.

From what I can tell 220-age seems to be a rough population calculation - sort of like BMI.

It is a starting point, but fit individuals increase their max heart rate and should take a stress test.

https://en.wikipedia.org/wiki/Heart_rate#Maximum_heart_rate

Re: Aerobic exercise can reduce the risk of metastatic cancer in mice: study

#79

Post by kritiko »

racking7 wrote: post #71
kritiko wrote: post #48

Earlier quoted context omitted.

Have you actually tested your max heart rate? I work out with a HRM for Zone 2, but I'm just going off of Polar's zones. From what I understand going more in depth requires either maxing out your HR (Steve House describes how you can do this in Training for the New Alpinism - basically sprinting uphill until you collapse, seems really unpleasant) or doing lactate testing in a lab.

You should check out doing an Aerobic Threshold (AeT) test and an Anaerobic Threshold (AnT) test. I believe there are details on the Uphill Athlete site. But you should absolutely determine your AeT if you’re trying to base build in zone 2 (180-age is a good place to start, but it is likely lower). AnT is useful as well for higher zone training. It’s a more demanding test than AeT but will give you a more practical u…

Thanks for the tip -- for others, here's a link to the Uphill Athlete article on aerobic testing:

https://uphillathlete.com/aerobic-training/aerobic-anaerobic...

Re: Aerobic exercise can reduce the risk of metastatic cancer in mice: study

#80

Post by dilyevsky »

canucker2016 wrote: post #73
dilyevsky wrote: post #35

Earlier quoted context omitted.

If you’re training regularly 80-85% is nowhere near where your lungs burn - that’s like below 165bpm for most people

80-85% max heart rate is tempo pace - people suggest it's around the pace that one can hold for one hour

Most runners i follow on strava and myself can sustain 85% hr over entire marathon race (with nutrition). It hurts after a while but it’s quite doable
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