A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila • Hacker News Board

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#71

Post by lr4444lr » Sun, Nov 13, 2022, 5:41 PM UTC

verisimi wrote: post #8

socialismisok wrote: post #2

I'd love to have some help with this. I was able to drop meat, most dairy, and salty junk food without problem. I eat plenty of green leafy vegetables. But sugar. Fuuuck I cannot walk past sweets. Sugar has claws in me I cannot shake. I hope we someday understand that mechanism better, maybe enough to give me a little help.

Don't drop salt, imo. It is essential for strong stomach acid (a whole system benefit), your body always ensures the salt level in the blood (and will even extract it from bones). Ask yourself - 'what is the most common medical intervention' and you will see it is a saline drip. And farmers ensure that salt is available to the their cattle for their health. And Japanese have a highly salty diet and live long, with fe…

The evidence behind the salt/hypertension link is very well established, with direct experimentation. I wish it weren't, and I realize it's highly individualized, and the average safe daily consumption might be higher than the current RDA, but let's not pretend that we can safely eat as much sodium as we want with no consequences.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#72

Post by spacemannoslen » Sun, Nov 13, 2022, 5:42 PM UTC

drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Over experimenting with my own body with diet through about 20 years I'm always amazed at how big a role habit plays in appetite.

When I did intermittent fasting I got into the habit of never needing food until around 4pm.

The body adapts fairly quickly to whatever inputs you feed it, and it's amazing how little of diet advice focuses on that, to me

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#73

Post by dataflow » Sun, Nov 13, 2022, 5:44 PM UTC

asciimov wrote: post #12

socialismisok wrote: post #2

I'd love to have some help with this. I was able to drop meat, most dairy, and salty junk food without problem. I eat plenty of green leafy vegetables. But sugar. Fuuuck I cannot walk past sweets. Sugar has claws in me I cannot shake. I hope we someday understand that mechanism better, maybe enough to give me a little help.

Advice from a T2 Diabetic and regular Keto dieter. If you have never given up sugar before, it will take at least 6-8 weeks of non-use before the cravings go away. These will be some of the hardest weeks too. 1) everything has sugar in it, and you have to absolutely avoid it, not just sweets, fruits, juices, I'd even tell you diet drinks and artificial sweeteners too. That means no ketchup, sauces, breads, and most p…

> everything has sugar in it, and you have to absolutely avoid it, not just sweets, fruits, juices, I'd even tell you diet drinks and artificial sweeteners too. That means no ketchup, sauces, breads, and most processed and store bought foods.

Realistically how do you avoid sugar like this? Soft drinks, candy, and other artificial stuff are easy enough to avoid, but most bread? Fruits? What are you supposed to eat and how are you supposed to obtain it without involving sugar? Are you suggesting people eat pure meat and lettuce and eggs for 6-8 weeks? It would be so much more helpful to give some examples of sample diets people could actually follow.

(What specifically are you saying needs to be avoided btw? Sucrose and fructose and artificial sweeteners I assume, but not glucose?)

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#74

Post by drowsspa » Sun, Nov 13, 2022, 5:47 PM UTC

bogota wrote: post #57

drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Lol stop making life complex nothing about your comment says CICO is wrong. Self control on the other hand is a problem that a lot of people have. But im sure we will find the .1% of random issues to talk about instead. People love to say its easy for you or make up all kinds of excuses. A person i dated in the pst liked to complain about how she couldn’t lose weight because of all these genetic issues. Both of her p…

"It's a self-control issue" well, obviously? It's also a completely useless and un-actionable observation, unless your goal is to feel better by pointing fingers, in which case, suit yourself.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#75

Post by ChadNauseam » Sun, Nov 13, 2022, 5:48 PM UTC

nonrandomstring wrote: post #68

drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

It seems surprising that almost no progress has been made in appetite suppression since they used to prescribe amphetamines as "diet pills" in the 1950s. I found just a few spoons of stodgy porridge can keep hunger away for 6 - 8 hours.

Tons of progress has been made actually. Semaglutide works amazingly well at appetite suppression, and there are human trials going on now for drugs that seem to be even better. I wrote about it here [0].

[0]: https://chadnauseam.com/random/semaglutide-has-changed-the-w...

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#76

Post by scarecrowbob » Sun, Nov 13, 2022, 5:50 PM UTC

zemvpferreira wrote: post #23

asciimov wrote: post #12

Earlier quoted context omitted.

Advice from a T2 Diabetic and regular Keto dieter. If you have never given up sugar before, it will take at least 6-8 weeks of non-use before the cravings go away. These will be some of the hardest weeks too. 1) everything has sugar in it, and you have to absolutely avoid it, not just sweets, fruits, juices, I'd even tell you diet drinks and artificial sweeteners too. That means no ketchup, sauces, breads, and most p…

As someone who's done every eating regimen under the sun, one top tip to get over the habit hump much quicker: water fasting. After ingesting nothing but water, coffee and electrolytes for 3-5 days your eating compulsions will be immediately reset. It's incredible how quick the effect is when you go extreme. It's not magic but it is pretty close.

I have had similar experiences; I did a lot of water fasting, lost a lot of weight (50lbs over 18mos), and then after all that fasting the sugary things just were not as appealing.

On top of that, I find it easier to go into water fasting if I've been in ketosis for a bit, which is difficult in itself.

But for that, I've found it helpful to remove other dietary restrictions; I don't typically eat dairy, and the stuff I do like to eat in keto is often much more expensive than the beans and rice / peanuts/ fruit that are the staples of my diet when I'm not trying to force ketosis or fast. Eating nicer food (usually meats, lots of eggs, dairy) makes being that process easier.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#77

Post by bugfix-66 » Sun, Nov 13, 2022, 5:51 PM UTC

DontchaKnowit wrote: post #48

bugfix-66 wrote: post #17

Earlier quoted context omitted.

We have an old, safe, cheap drug for humans already: Metformin. Most people can get an off-label metformin prescription for anti-aging or appetite suppression. Your interest in food will be reduced to the point you have trouble keeping weight on. Sugar will be repulsive to you. Sweet food tastes "sickly sweet", nauseating. Metformin also interferes with the absorption of carbohydrates in your gut.

Yeah tell that to my stress eating family members who all have metformin prescriptions. This may be true for some people but definitely not a universal

Here's a question to consider: How much worse would the situation be if they weren't on metformin?

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#78

Post by WhitneyLand » Sun, Nov 13, 2022, 5:52 PM UTC

It seems like there’s some interest here in what progress has been made in appetite suppressants recently.

The drug mentioned in these links was just FDA approved this year and some are calling it a legit breakthrough.

At first it looks like only a diabetes drug, but it’s dual use, prescribed for weight loss as well. It’s expensive, but for those with high blood sugar it is sometimes, covered by insurance.

https://www.nytimes.com/2022/05/31/health/obesity-drugs-insu...

https://www.fda.gov/news-events/press-announcements/fda-appr...

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#79

Post by guerrilla » Sun, Nov 13, 2022, 5:56 PM UTC

flamebreath447 wrote: post #54

drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

What doesn’t make sense about your statement is that CICO evangelists don’t claim that appetite or that satiation isn’t a problem. One of the best examples I know of is Greg Doucette. He specifically preaches CICO because for 95-99% of people it is about putting the fork down. It’s a generalization because, more often than not you aren’t controlling your intake if you are overweight. There will always be the minority…

> It’s a generalization because, more often than not you aren’t controlling your intake if you are overweight. There will always be the minority that truly have hormonal imbalances and need assistance losing weight.

But we know it's not a minority. Most people who try to eat less fail, repeatedly, for all of their lives.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#80

Post by bityard » Sun, Nov 13, 2022, 5:58 PM UTC

omgwtf1000 wrote: post #16

asciimov wrote: post #12

Earlier quoted context omitted.

Advice from a T2 Diabetic and regular Keto dieter. If you have never given up sugar before, it will take at least 6-8 weeks of non-use before the cravings go away. These will be some of the hardest weeks too. 1) everything has sugar in it, and you have to absolutely avoid it, not just sweets, fruits, juices, I'd even tell you diet drinks and artificial sweeteners too. That means no ketchup, sauces, breads, and most p…

I so want to do this, but I have such a sweet tooth I don’t think I can succeed. I can go a few days without sweets but then the urge is just overwhelming. I want to try weaning, by just eating fruit instead of processed treats. Will that have any effect at all, make it harder overall, or is the only way to just cut sugar completely?

As a long-term keto dieter (10+ years), my advice is never be afraid to experiment with your diet. Every time you try something new and the results were not what you were hoping for, treat it as a learning experience, not a failure. What constitutes a healthy diet (both mentally and physically) is different for everyone.

As an example, cutting out candy and donuts for apples and pears isn't keto, but is objectively a step in the right direction. If you want to give it a try, just go for it and see what happens!