Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

nature.com

Post reply on HN
Print view View original

51–60 of 162 posts

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#51

Post by csours »

freddie_mercury wrote: post #41
drowsspa wrote: post #10

Earlier quoted context omitted.

Willpower is a finite resource indeed, you can't rely on that.

Current research suggests that willpower is not a finite research and "ego depletion" was a spurious finding. https://www.psychologytoday.com/us/blog/how-do-you-know/2020...

I think willpower is a description of the human experience. I don't know if it's a good mechanistic description or not. It does not seem to be taken seriously as a cause by many psychologists.

Whatever you think of willpower, I think controlling the food environment (don't bring it home from the store, don't eat at restaurants with mainly junk food, etc) is the most effective intervention. After that, things like substitution, delay, smallest possible portion, and putting the tempting food in an inconvenient location may help.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#52

Post by garbanz0 »

ethanbond wrote: post #47
dabbledash wrote: post #24

Earlier quoted context omitted.

Appetite differences are almost certainly the primary factor in why some people get heavy and others don't, but that isn't inconsistent with CICO at all.

It’s not inconsistent (obviously, because thermodynamics), but it does make CICO a pretty useless contribution to the conversation. Not the silver bullet that proponents position it as. Successful dieting is about managing the sensation of hunger. That’s it.

I've noticed a lot of overweight people using food as a crutch to manage emotional discomfort or distress, even when they might not be all that hungry. So there is something else going on.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#53

Post by beebeepka »

socialismisok wrote: post #2

I'd love to have some help with this. I was able to drop meat, most dairy, and salty junk food without problem. I eat plenty of green leafy vegetables. But sugar. Fuuuck I cannot walk past sweets. Sugar has claws in me I cannot shake. I hope we someday understand that mechanism better, maybe enough to give me a little help.

Fruits and nuts.

I used to consume about 1.5 litres of ice cream every day. I still get the cravings but less and less. Good thing my wife is making fruit salads for me.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#54

Post by flamebreath447 »

drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

What doesn’t make sense about your statement is that CICO evangelists don’t claim that appetite or that satiation isn’t a problem.

One of the best examples I know of is Greg Doucette. He specifically preaches CICO because for 95-99% of people it is about putting the fork down. It’s a generalization because, more often than not you aren’t controlling your intake if you are overweight. There will always be the minority that truly have hormonal imbalances and need assistance losing weight.

If you have a higher appetite you should have learned about low calorie dense foods, and if you’re serious about losing or maintaining a healthy weight you have to find sustainable foods you like that fill you but are lower in calories.

There’s a heirarchy in terms of trouble shooting your weight problems and proper jumping to NEAT and hormonal imbalances is really just trying to take a shortcut for instant gratification.

Long term you can lose 1 pound a month, slowly, and keep it off the rest of your life via CICO.

Sorry for the rant but I can’t stand people who skip CICO cause they don’t like to hear it and haven’t done research on how to keep themselves full.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#55

Post by dylan604 »

bugfix-66 wrote: post #34
CharlesW wrote: post #30

Earlier quoted context omitted.

> Most people can get an off-label metformin prescription for anti-aging. Dumb question: How? I'm reasonably certain my GP would not be amenable to being asked to prescribe drugs for off-label use.

Just ask your doctor for it. Say: "Please prescribe me Metformin, 2 grams daily." If you're overweight, tell your doctor you want help with your appetite. Otherwise, say you want metformin for its cancer prevention and anti-aging effects. Metformin is safe and it almost universally improves health and well-being. Your doctor knows this, and she'll gladly prescribe it.

> Your doctor knows this, and she'll gladly prescribe it.

If your doctor gladly prescribes anything you just walk in and ask for by name and dosage and doesn't have a green cross symbol outside their office, then I'd highly suggest seeking out a new doctor.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#56

Post by beebeepka »

drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Uh huh. I've heard all the excuses. I am sure fat people understand thermodynamics just fine. What they lack is restraint. Never met a fat person with sane eating habits

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#57

Post by bogota »

drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Lol stop making life complex nothing about your comment says CICO is wrong. Self control on the other hand is a problem that a lot of people have. But im sure we will find the .1% of random issues to talk about instead.

People love to say its easy for you or make up all kinds of excuses. A person i dated in the pst liked to complain about how she couldn’t lose weight because of all these genetic issues. Both of her parents were fat and she had recently started to get a lot bigger. I said i would diet with her eating the same amount of calories even though i work out 5 times a week and need 2200 calories just to maintain my weight normally i am eating 2400 to 2600 since my goal is muscle gain. She needed likely about 1800 based on sex, height, and activity level. We both targeted 1600 calories a day.

I lost close to ten pounds (this is not at all healthy dont do it) she lost 4 pounds. I stopped after a month and she was unable to keep doing it alone without me doing all the meal planning and just generally because she was lazy.

I never had to hear about how it was because i was lucky again which was great. I had serious hunger cravings for the entire month but guess what you can decide to not eat.

Prepared for my downvotes from all the people “stuck” at unhealthy weight.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#58

Post by maxk42 »

huntertwo wrote: post #26
drowsspa wrote: post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Hormones, appetite, metabolic diseases are all orthogonal to CICO. These can have an effect on how many calories you burn or how many calories you crave but at the end of the day, CICO is still law.

A calorie measures the heat released by setting the food on fire, which is not how your body metabolizes food. It's a proxy. You should be measuring the ATP yielded by eating food. For example, a molecule of glucose yields 32 ATP when metabolized, yet a molecule of DHA yields 136 molecules of ATP - nearly twice as many as predicted by the "calories" proxy. However, in the absence of oxaloacetic acid (as when the liver is using the majority of OAA for gluconeogenesis during intense exercise or when limiting carbohydrate consumption) your cells have to use a less efficient series of metabolic steps to produce energy and only end up yielding 22 ATP for DHA metabolism. I eat 3500 calories a day and don't exercise yet I'm losing about 2 pounds of fat per week.

CICO was never law.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#59

Post by antiterra »

adrian_b wrote: post #39
dabbledash wrote: post #24

Earlier quoted context omitted.

Appetite differences are almost certainly the primary factor in why some people get heavy and others don't, but that isn't inconsistent with CICO at all.

In my opinion, the differences in appetite are caused mostly by the differences in the type of food eaten, and not by the differences between humans. In my search for a diet that would allow me to avoid gaining weight, the main successes were achieved by replacing various kinds of food that were tasty, but which did not satiate me before eating huge amounts of them, with other kinds of food that are also tasty, but w…

I have known plenty of people who ate very small amounts of garbage food (eg only candy & hot pockets) and didn’t gain weight.

Some instances this seemed due to an incredibly fast metabolism, others were due to GERD/IBS or some other factor that limits the craving.

The differences are real, even if it’s just something like gut biome.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#60

Post by maxk42 »

omgwtf1000 wrote: post #16
asciimov wrote: post #12

Earlier quoted context omitted.

Advice from a T2 Diabetic and regular Keto dieter. If you have never given up sugar before, it will take at least 6-8 weeks of non-use before the cravings go away. These will be some of the hardest weeks too. 1) everything has sugar in it, and you have to absolutely avoid it, not just sweets, fruits, juices, I'd even tell you diet drinks and artificial sweeteners too. That means no ketchup, sauces, breads, and most p…

I so want to do this, but I have such a sweet tooth I don’t think I can succeed. I can go a few days without sweets but then the urge is just overwhelming. I want to try weaning, by just eating fruit instead of processed treats. Will that have any effect at all, make it harder overall, or is the only way to just cut sugar completely?

Merely tasting sweetness causes an anticipatory rise in insulin which shuts down fat metabolism. Best to go cold turkey, unfortunately. You can control cravings, however, by raising your fat intake to the point where you're too full to find eating more appetizing. You will still lose weight like this on a ketogenic diet.
Post reply on HN