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A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

nature.com

21–30 of 162 posts

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#21

I'd love to have some help with this. I was able to drop meat, most dairy, and salty junk food without problem. I eat plenty of green leafy vegetables. But sugar. Fuuuck I cannot walk past sweets. Sugar has claws in me I cannot shake. I hope we someday understand that mechanism better, maybe enough to give me a little help.

[deleted]

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#22
post #8

Earlier quoted context omitted.

Don't drop salt, imo. It is essential for strong stomach acid (a whole system benefit), your body always ensures the salt level in the blood (and will even extract it from bones). Ask yourself - 'what is the most common medical intervention' and you will see it is a saline drip. And farmers ensure that salt is available to the their cattle for their health. And Japanese have a highly salty diet and live long, with fe…

Don't drop sugar imo For all the similar reasons you gave, except - no sugar, no energy. You may wonder why a skinny af cyclist will happily consume 6k+ calories a day, as well as shovelling glucose gels down. Endurance athletes get it best: long distance cycling is just an all-day eating competition.

Most people on here are probably spending 10hrs/day in front of a screen, though. And in that case, more calories is unlikely to be the answer to a lack of energy/focus.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#23

I'd love to have some help with this. I was able to drop meat, most dairy, and salty junk food without problem. I eat plenty of green leafy vegetables. But sugar. Fuuuck I cannot walk past sweets. Sugar has claws in me I cannot shake. I hope we someday understand that mechanism better, maybe enough to give me a little help.

Advice from a T2 Diabetic and regular Keto dieter. If you have never given up sugar before, it will take at least 6-8 weeks of non-use before the cravings go away. These will be some of the hardest weeks too. 1) everything has sugar in it, and you have to absolutely avoid it, not just sweets, fruits, juices, I'd even tell you diet drinks and artificial sweeteners too. That means no ketchup, sauces, breads, and most p…

As someone who's done every eating regimen under the sun, one top tip to get over the habit hump much quicker: water fasting.

After ingesting nothing but water, coffee and electrolytes for 3-5 days your eating compulsions will be immediately reset. It's incredible how quick the effect is when you go extreme. It's not magic but it is pretty close.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#24
post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Appetite differences are almost certainly the primary factor in why some people get heavy and others don't, but that isn't inconsistent with CICO at all.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#25
post #8

Earlier quoted context omitted.

Don't drop salt, imo. It is essential for strong stomach acid (a whole system benefit), your body always ensures the salt level in the blood (and will even extract it from bones). Ask yourself - 'what is the most common medical intervention' and you will see it is a saline drip. And farmers ensure that salt is available to the their cattle for their health. And Japanese have a highly salty diet and live long, with fe…

Don't drop sugar imo For all the similar reasons you gave, except - no sugar, no energy. You may wonder why a skinny af cyclist will happily consume 6k+ calories a day, as well as shovelling glucose gels down. Endurance athletes get it best: long distance cycling is just an all-day eating competition.

Endurance athletes are getting frequent and strenuous exercise. Most people don't. There's a lot of concern and advice in this thread about diet, but exercising more is the step that's missing. We live in the hydrocarbon era of easy transport, which means cheap food and little exercise. Both of those have to be addressed for good health, not just the food.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#26
post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

Hormones, appetite, metabolic diseases are all orthogonal to CICO. These can have an effect on how many calories you burn or how many calories you crave but at the end of the day, CICO is still law.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#27
I have gained and lost a ton of weight several times in my life. While I did also notice and make use of the hormone imbalances that affect me (depending on where your fat is you can estimate what hormone is acting up), in my experience it has been that food appetite or enjoyment is maybe 10% of the struggle with another 10% being environmental factors but 80% comes down to the answer to a simple question: Is the advantage or profit of weight loss worth the discomfort and hard work? We all know objectively speaking it is, but as an individual, do I care enough? What do I get out if it in the end that is worth it, for me?

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#28

I'd love to have some help with this. I was able to drop meat, most dairy, and salty junk food without problem. I eat plenty of green leafy vegetables. But sugar. Fuuuck I cannot walk past sweets. Sugar has claws in me I cannot shake. I hope we someday understand that mechanism better, maybe enough to give me a little help.

Maybe eat dairy and meat instead? These foods are less harmful to you and less likely to leave you hungry than sugar and processed foods.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#29
post #8

Earlier quoted context omitted.

Don't drop salt, imo. It is essential for strong stomach acid (a whole system benefit), your body always ensures the salt level in the blood (and will even extract it from bones). Ask yourself - 'what is the most common medical intervention' and you will see it is a saline drip. And farmers ensure that salt is available to the their cattle for their health. And Japanese have a highly salty diet and live long, with fe…

Don't drop sugar imo For all the similar reasons you gave, except - no sugar, no energy. You may wonder why a skinny af cyclist will happily consume 6k+ calories a day, as well as shovelling glucose gels down. Endurance athletes get it best: long distance cycling is just an all-day eating competition.

The analogy between salt and sugar does not really work.

Sugar is not an essential nutrient. You can eat absolutely no sugar without any ill effect. If you eat some starchy vegetables, that provides all the carbohydrates you need.

Even if you want to eat 6000 kcal as carbohydrates, you can eat that easily from rice/maize/bread/potatoes etc., with no sugar. In fact it is much easier to eat a huge amount of food when it does not contain sugar, because even if sugar is addictive and makes you crave for it, when you eat too much sugar during a short time, it becomes disgusting when you try to eat more.

On the other hand, if you stop eating salt, or even if you just eat too little salt, you will die soon, and not in a pleasant way (e.g. one of the symptoms of hyponatremia caused by eating too little salt is severe constipation, because various muscles, including the muscles that are used for the peristalsis of the intestines, lose their strength).

Like for any essential nutrient, both eating too little salt and eating to much salt is bad. The recommended daily intake of salt is between 4 and 5 grams of salt.

In order to be able to control precisely the daily intake of salt, I prefer to not add any salt to food during cooking (and I do not buy industrially made food). Instead of that, I add the salt only immediately prior to eating, so I can know exactly the amount added during a day.

Re: A gut-derived hormone suppresses sugar appetite/regulates food choice Drosophila

#30
post #9

I've been hitting the gym for a few months now, and one thing that completely blew my mind was the existence of hypercalorics. Imagine that, not being able to eat a lot (specially carbs) and having to resort to these solutions. Point being, people like to spew out CICO as if fat people just don't understand thermodynamics. What I've found is that matters is appetite: some people just get full way faster than others.…

We have an old, safe, cheap drug for humans already: Metformin. Most people can get an off-label metformin prescription for anti-aging or appetite suppression. Your interest in food will be reduced to the point you have trouble keeping weight on. Sugar will be repulsive to you. Sweet food tastes "sickly sweet", nauseating. Metformin also interferes with the absorption of carbohydrates in your gut.

> Most people can get an off-label metformin prescription for anti-aging.

Dumb question: How? I'm reasonably certain my GP would not be amenable to being asked to prescribe drugs for off-label use.

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