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Study: Electroshock therapy more successful for depression than ketamine

today.uconn.edu

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Re: Study: Electroshock therapy more successful for depression than ketamine

#151

Post by joelrunyon »

tomcam wrote: post #143
engined wrote: post #85

After dealing with depression myself, I dove deeply into this world, and actually ended up founding a ketamine and esketamine treatment startup in the Boston area (lumin.health). We've seen pretty amazing results with patients who have otherwise failed antidepressants and/or ECT and TMS (Transcranial Magnetic Stimulation). The reality is that ketamine/esketamine are much more accessible from a patient perspective, an…

Thank you. Any help for insomnia or overeating?

If you're struggling with sleep and "turning the lights off" around bed time - we made a custom natural sleep product for high performers focused on quality, restful sleep - https://impossible.co/products/sleep

Shoot me a DM if you want to try it out - happy to send one your way.

Re: Study: Electroshock therapy more successful for depression than ketamine

#152

Post by IndySun »

tomcam wrote: post #143
engined wrote: post #85

After dealing with depression myself, I dove deeply into this world, and actually ended up founding a ketamine and esketamine treatment startup in the Boston area (lumin.health). We've seen pretty amazing results with patients who have otherwise failed antidepressants and/or ECT and TMS (Transcranial Magnetic Stimulation). The reality is that ketamine/esketamine are much more accessible from a patient perspective, an…

Thank you. Any help for insomnia or overeating?

Overeating might be helped by knowing your own body's blood sugar response to carbs. Take a browse through Tim Spectors ZOE. Hope you get some progress.

Re: Study: Electroshock therapy more successful for depression than ketamine

#153

Post by victor106 »

joelrunyon wrote: post #151
tomcam wrote: post #143

Earlier quoted context omitted.

Thank you. Any help for insomnia or overeating?

If you're struggling with sleep and "turning the lights off" around bed time - we made a custom natural sleep product for high performers focused on quality, restful sleep - https://impossible.co/products/sleep Shoot me a DM if you want to try it out - happy to send one your way.

> Why Melatonin is Bad For You (coming soon).

I am curious to read why this is bad. My doc thinks this is perfectly fine

Re: Study: Electroshock therapy more successful for depression than ketamine

#154

Post by tekknik »

boredtofears wrote: post #136
sneak wrote: post #118

Earlier quoted context omitted.

Ketamine’s effects on depression are not caused by the hallucinations or psychedelic effects. I can’t speak to other hallucinogens but I would imagine the situation is the same there. The day after an acid trip isn’t a new neurochemical environment because of the powerful hallucinations the day before, it is something else. > My own experience with psychedelics tells me no: once you become familiar with the effects t…

> The day after an acid trip isn’t a new neurochemical environment because of the powerful hallucinations the day before, it is something else What is a "new neurochemical environment" exactly? I've had many acid comedowns, and they have all been affected by how the high was - emotionally, mentally, and physically. What do you mean by "its something else"?

I’m far from an expert here, but as I understand it there is no repeated, or daily dose of the psilocybin. Instead it physically changes your brain. Here’s one study:

https://www.mdpi.com/1422-0067/22/2/835/htm

Re: Study: Electroshock therapy more successful for depression than ketamine

#155

Post by toss1 »

olliej wrote: post #138
toss1 wrote: post #10

Earlier quoted context omitted.

Yes, an acquaintance from college went through ECT. The guy was previously brilliant. Yes, his illness was part of his later problems, but he was wholly convinced that the ECT was a much larger problem. So much so that as soon as he got out of the institution, he commenced lawsuits against his parents who had set up his treatment (as far as I could tell for legit reasons; it wasn't one of those horror stories of abus…

The rules for use of ECT are much more strict than they were in the past, so when this happened would be extremely important. ECT as used well into the 80s, possibly even the 90s, was pretty much aversion therapy - essentially just: "you'll behave properly or we'll torture you". In CA at least the rules for use of ECT nowadays are extremely strict, and required frequent confirmation of understanding of what you think…

Well, it was in the late 1980s, and it certainly created an aversion response! (although perhaps not the intended reaction) >> was pretty much aversion therapy - essentially just: "you'll behave properly or we'll torture you".

If it has changed sufficiently to be essentially unrecognizable vs prior practice, that is probably a good thing... Still, knowing what I do about neuroscience from a minor in college, it still seems like heavy artillery barrages to deal with an insect infestation, or burn the village to save it. The real work of the brain & nervous system happens in hundreds of subtle interactions within cells and in the synapses, the patterns of the synapses, etc, and this is just a global sledgehammer. It'll likely have measurable effects, although 50% seems pretty much like toss-a-coin Russian Roulette with your brain. Perhaps an OK bet in true desperation, but...

Re: Study: Electroshock therapy more successful for depression than ketamine

#156

Post by engined »

tomcam wrote: post #143
engined wrote: post #85

After dealing with depression myself, I dove deeply into this world, and actually ended up founding a ketamine and esketamine treatment startup in the Boston area (lumin.health). We've seen pretty amazing results with patients who have otherwise failed antidepressants and/or ECT and TMS (Transcranial Magnetic Stimulation). The reality is that ketamine/esketamine are much more accessible from a patient perspective, an…

Thank you. Any help for insomnia or overeating?

(This is not medical advice and I am not a doctor) I don't think ketamine is directly indicated overeating, and I know esketamine isn't for insomnia or overeating. That said, There do seem to be a handful of papers studying the use of ketamine in things that affect sleep, like circadian rhythm [0][1]. In general, ketamine causes sedation in about 70% of those treated with it. Though that is short acting (hours) it may help set an individual for a good sleep, and to the extent that insomnia or overeating are caused by or co-occurrent with depression, ketamine could likely help.

[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866161/ [1] https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.1423

Re: Study: Electroshock therapy more successful for depression than ketamine

#157

Post by KMnO4 »

victor106 wrote: post #153
joelrunyon wrote: post #151

Earlier quoted context omitted.

If you're struggling with sleep and "turning the lights off" around bed time - we made a custom natural sleep product for high performers focused on quality, restful sleep - https://impossible.co/products/sleep Shoot me a DM if you want to try it out - happy to send one your way.

> Why Melatonin is Bad For You (coming soon). I am curious to read why this is bad. My doc thinks this is perfectly fine

Going out on a limb here, but I’m assuming it’s meant to be “why [exogenous] melatonin is bad for you”.

Melatonin is naturally secreted by the pineal gland, which like other hormones gets downregulated when taken exogenously over long periods of time.

There’s also studies showing a downregulation in dopamine and seratonin with long term use of melatonin.

Re: Study: Electroshock therapy more successful for depression than ketamine

#159

Post by Jerrrry »

These two treatments being anywhere comparable is a massive disservice and borderline negligent.

Feeling a little loopy from a hefty Ket dose and having permanent brain damage from being shocked are so far removed from each other that it is an actual failing in different regards.

Drugs may figuratively fry your brain, but it is certainly better than literally frying your fuckin brain.

Re: Study: Electroshock therapy more successful for depression than ketamine

#160

Post by jamincan »

MonkeyMalarky wrote: post #52
denzilla8080 wrote: post #13

Earlier quoted context omitted.

The headaches and muscle pain are temporary. But the memory loss is severe and while not truly hindering, definitely life altering. Years are just blurred together. Some things and people just aren’t there and it’s really hard for me to remember on my own. It more changes the relationship you have with your memory.

Memories disappear in depression on their own already. Whole spans of my 20s are just gone.

That's my experience as well. That entire part of my life is just blurred together.
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