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A rash of nearly lethal mushroom poisonings in Ohio

cleveland.com

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Re: A rash of nearly lethal mushroom poisonings in Ohio

#271

Post by s1artibartfast »

smeej wrote: post #229
411111111111111 wrote: post #223

Earlier quoted context omitted.

> This literally takes an army of people working after hours,” said Gholam. “There are tireless, really unsung heroes at the UH research office who make this happen for every patient – they have to do this over and over and over.” Forty-seven times in the last 10 years to be exact. Ohh, the poor guys have to hand in 4.7 forms per year to get access to an unapproved medicine they need. I would've thought it was satire…

Why is something that's been approved in Europe for 30 years still waiting for FDA approval in the first place? If they issue the medication immediately after the form is submitted, without further inquiry or scrutiny (which is actually good in the case of something this urgent), why are they even bothering keeping it under such lock and key anyway? That's what would sound like satire to anyone without an unflinching…

The point is to track and monitor its use if it is not approved. The inquiry and scrutiny exists. Im not sure why you assume it doesnt.

Do all of the patients die from the drug? Are doctors administer it as a new fad for the common cold, ect?

Re: A rash of nearly lethal mushroom poisonings in Ohio

#272

Post by msrenee »

Aloha wrote: post #130
nkurz wrote: post #44

Since no one has done it yet, I'll ask the obvious question about the FDA: how many people die or need a liver transplant each year because the FDA is being unreasonable here? Here's some quotes from the article: Approximately 40% of people who ingest the deadly Amanita mushrooms die or require a liver transplant, according to Dr. Pierre Gholam, the liver specialist at University Hospitals who treated Hickman. ... Th…

"Gholam says that the process of FDA approval for Silibinin is slow, primarily because it only works for amatoxin poisoning, from the Amanita mushroom species. Those poisonings are rare – so gathering enough data to satisfy the safety and efficacy requirements of the FDA takes time. And there is little financial incentive by the company that owns the drug to invest in its research and development." Incidentally, thes…

>And there is little financial incentive by the company that owns the drug to invest in its research and development.

This is the real reason it hasn't been approved. If only we had some kind of system in place where profit wasn't the main, and often only, motivator for getting life-saving medications approved by the FDA.

Re: A rash of nearly lethal mushroom poisonings in Ohio

#273

Post by marmadukester39 »

mhb wrote: post #244
boppo1 wrote: post #188

Earlier quoted context omitted.

I'd trust European data more than , say chinese or pakistani data. However, that kind of exclusivity is politically untenable.

Fortunately, realpolitik can still prevail over wokeism in international affairs in which there are obvious life and death consequences.

What does this have to do with wokeism?

Re: A rash of nearly lethal mushroom poisonings in Ohio

#275

Post by dekhn »

Aloha wrote: post #130
nkurz wrote: post #44

Since no one has done it yet, I'll ask the obvious question about the FDA: how many people die or need a liver transplant each year because the FDA is being unreasonable here? Here's some quotes from the article: Approximately 40% of people who ingest the deadly Amanita mushrooms die or require a liver transplant, according to Dr. Pierre Gholam, the liver specialist at University Hospitals who treated Hickman. ... Th…

"Gholam says that the process of FDA approval for Silibinin is slow, primarily because it only works for amatoxin poisoning, from the Amanita mushroom species. Those poisonings are rare – so gathering enough data to satisfy the safety and efficacy requirements of the FDA takes time. And there is little financial incentive by the company that owns the drug to invest in its research and development." Incidentally, thes…

Thalidomide is a very useful drug that is still prescribed today.

Re: A rash of nearly lethal mushroom poisonings in Ohio

#276

Post by salawat »

dekhn wrote: post #275
Aloha wrote: post #130

Earlier quoted context omitted.

"Gholam says that the process of FDA approval for Silibinin is slow, primarily because it only works for amatoxin poisoning, from the Amanita mushroom species. Those poisonings are rare – so gathering enough data to satisfy the safety and efficacy requirements of the FDA takes time. And there is little financial incentive by the company that owns the drug to invest in its research and development." Incidentally, thes…

Thalidomide is a very useful drug that is still prescribed today.

>Thalidomide is a very useful drug that is still prescribed today.

With a metric shit ton of caveats, that were outright denied until the public raised an unholy fuss with regulators to get it clamped down on in light of the severity of birth defects/reproductive complications it produces.

Re: A rash of nearly lethal mushroom poisonings in Ohio

#277

Post by retrac »

junglistguy wrote: post #152
changoplatanero wrote: post #2

Mushroom foraging sounds really fun but I’m too scared to eat anything that I find.

And aren't you terrified of eating food from a supermarket full of chemicals?

Depending where you are, that worry might be greater with foraged berries, mushrooms etc. I live in an area that's been heavily industrialised for over 150 years. The soil at my mom's place when tested had too much lead and PCBs for safety. And not too long ago they found leaking barrels of nuclear waste from the 1940s in a lovely wooded area just a couple blocks over from my old primary school. Only God knows what's in the soil here, unless you test it.

Re: A rash of nearly lethal mushroom poisonings in Ohio

#278

Post by brycemice »

I am an novice mycologist and I just find it ridiculous that theres people out there picking mushrooms, cooking and eating them without ever having the knowledge of the species of mushrooms that grow in their region. Anyone picking and eating mushys without knowning the harmful species in their regions are simply asking for it. Do it and its only a matter of time before you or your app make a mistake and you end up in the hospital or a coffin. But regardless I'll break down the best practices in identifying mushys.

1. When ID'ing mushrooms look for 3 points of comparison. Never go on one comparison. Any good mushy ID's will document size shape color smell bruising color.

2. Use more than 1 set of eyes. Just because your convinced doesn't mean your right. Post pictures to a forum and get some other eyes on the specimen and make sure your ID is confirmed.

3. From my experience the best place to start and ID is the medium its growing in. Soil Wood Excreta Moist Dry Sunny Time of Day. Find as many points of comparison as possible and when in doubt DONT EAT THE GD THING!

Re: A rash of nearly lethal mushroom poisonings in Ohio

#279

Post by 411111111111111 »

TomSwirly wrote: post #230
411111111111111 wrote: post #223

Earlier quoted context omitted.

> This literally takes an army of people working after hours,” said Gholam. “There are tireless, really unsung heroes at the UH research office who make this happen for every patient – they have to do this over and over and over.” Forty-seven times in the last 10 years to be exact. Ohh, the poor guys have to hand in 4.7 forms per year to get access to an unapproved medicine they need. I would've thought it was satire…

Oh, no, the amazing person is definitely you here. Here's a life-saving drug that US pharmacists (only) are not allowed to stock; a drug that saves lives but only if given in a small time windows; and to get this drug you need to fill out a form and simply hope that someone happens to be working at whatever time you start to die. And here you are, making fun of people who think this is a ridiculous idea! Who wrote th…

Yes, let's let doctors give out unapproved drugs whenever they want so they can finally properly profit by making their own premium drug brands. Really smart ideas, i totally agree.

My previous astonishment was clearly misplaced, these doctors know best after all.

Re: A rash of nearly lethal mushroom poisonings in Ohio

#280

Post by smeej »

s1artibartfast wrote: post #271
smeej wrote: post #229

Earlier quoted context omitted.

Why is something that's been approved in Europe for 30 years still waiting for FDA approval in the first place? If they issue the medication immediately after the form is submitted, without further inquiry or scrutiny (which is actually good in the case of something this urgent), why are they even bothering keeping it under such lock and key anyway? That's what would sound like satire to anyone without an unflinching…

The point is to track and monitor its use if it is not approved. The inquiry and scrutiny exists. Im not sure why you assume it doesnt. Do all of the patients die from the drug? Are doctors administer it as a new fad for the common cold, ect?

I assume it doesn't because U.S.-government-level "inquiry and scrutiny" takes at least an order of magnitude longer than 72 hours. If they're getting this done in time for it to be useful, it's just being rubber-stamped.

Do you sincerely think the EU would keep a drug available for common use if everyone who took it died? If not, drop the red herring and try to have a halfway serious discussion.

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