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Combination of Rapamycin and Acarbose significantly Extends Lifespan

lifespan.io

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Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#71

Post by hinkley »

ramraj07 wrote: post #33
jokowueu wrote: post #32

Earlier quoted context omitted.

A large amount of rapa was bought during a group buy It was devided up between people who couldn't afford or get it To be clear its not specifically an anti cancer med it's an immune suppressant. It targets mtor so it's great for autoimmune disease The group I belong to specifically are people that have diseases that couldn't be treated either because of financial reasons or because docs wouldn't prescribe meds off l…

So no actual medical professionals involved. Got it. Please start your comments with that, though. You do you, but last I remember I’ve never seen a single person who desperately tried to live long actually live long.

The vibe I get off of Aubrey de Grey is not here’s a man who wants to live forever, so much as here’s a man afraid of dying. And these days he’s starting to look like an origin story for a lich. He’s 5% ghoul and climbing. He needs Buddhism, not anti cancer drugs.

Once in a great while I see a movie character who wants to see how the story ends. Most of the rest and most of the real humans want to cheat death, which is a very different sentiment.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#73

Post by hinkley »

ck2 wrote: post #5

They've been studying Acarbose for awhile now https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789153/ The problem with a lot of these longevity approaches is they "solve the problem" by reducing energy conversion, like acarbose, pulling people to a baseline and preventing stress adaptations. Great for sitting around. The opposite of that for doing anything athletic, you'd never improve.

I have just gotten my resting heart rate back down to pre-quarantine levels. I don’t know how many days I shaved off my lifespan from all that sitting around, but I’m a little bitter about it.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#74

Post by marcosdumay »

JoshTko wrote: post #56
adrian_b wrote: post #43

Earlier quoted context omitted.

To be fair, there is little choice for any such study to be done on anything else but mice, because of their short natural lifespan. Even if there were human volunteers willing to test on themselves various cocktails of chemicals, such a study would take many centuries. Also on monkeys any study would take much too long. So until aging in mice is well understood, any tests on monkeys or humans are pointless. It is un…

Your last point needs to be emphasized more. The core mechanism of aging is likely to be very similar across species as aging affect all tissues, organs, etc.

AFAIK, the question of why our lifespan is so different from other mammals is still open. And one quite possible answer is still that our aging happens by a slightly different mechanism.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#77

Post by Tagbert »

adrian_b wrote: post #67
kevinventullo wrote: post #66

Earlier quoted context omitted.

It is unlikely that the aging mechanisms differ in an essential way between mice and humans. [citation needed]

A citation is needed for the contrary statement. Aging has appeared hundreds of millions of years ago in the ancestors of all multicellular animals and it manifests in the same way in most of them. There is no known reason for aging in a way to be replaced by aging in some other way, like e.g. respiration through gills may be replaced by respiration through lungs, especially when we discuss some closely related mamma…

Yes, and the closer the evolutionary relationship, the closer you would expect the biochemistry to be.

A result in yeast might not apply at all. a result in fish might be something worth investigating. A result in mice has a good likelihood of applying to humans. A money study would be a close match.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#78

Post by adrian_b »

marcosdumay wrote: post #74
JoshTko wrote: post #56

Earlier quoted context omitted.

Your last point needs to be emphasized more. The core mechanism of aging is likely to be very similar across species as aging affect all tissues, organs, etc.

AFAIK, the question of why our lifespan is so different from other mammals is still open. And one quite possible answer is still that our aging happens by a slightly different mechanism.

The lifespan of humans is not completely different from other mammals.

The lifespan of humans is less than twice that of our closest relatives, and probably there is no coincidence in the fact that about the same ratio exists between the maturity age of humans and that of apes.

Aging in humans does not seem to have any qualitative difference, it just happens slower, like also the maturity.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#79

Post by gdudeman »

dsq wrote: post #45

I remember there being a lot of noise a few years ago about resveratrol, and how red wine (but only of a certain grape) was the secret to long life. What happens if you make the wrong decision and go all in, drinking wine and gobbling grape seeds, while it turns about to be something else entirely and you missed the boat? There’s no end to it, especially as there are only two real solutions that work, extreme caloric…

I want to add some nuance to this:

Resveratrol probably doesn’t do anything. This same research group actually studied it on mice. If you were gobbling it, you’re neutral. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598361/

Young blood transfusions may work, but the research is certainly still thin. Interestingly, removing old blood seems to be the actual benefit, not the addition of young. Source: https://www.science.org/content/blog-post/young-blood-and-ol...

Extreme caloric restriction reduces lifespan, but there does seem to be a sweet spot of restriction that lengthens it.

None of these things are proven in humans however and we don’t really know the side effects. Do they give you dementia? Do they make you dumb? Unlikely, but we just don’t know.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#80

Post by lambdafourtwo »

jtbayly wrote: post #68
lambdafourtwo wrote: post #47

Earlier quoted context omitted.

rapamycin triggers the same effect as extreme caloric restriction. Neither of the solutions you mentioned have been scientifically verified in humans. Longevity research itself hasn't been around long enough to verify ANY longevity hypothesis on humans.

… in spite of being around for millennia.

The scientific method came around 1600s. Statistics existed in 1662.

Science itself has not existed for a millenia.

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