Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Combination of Rapamycin and Acarbose significantly Extends Lifespan

lifespan.io

Post reply on HN
Print view View original

41–50 of 84 posts

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#41

Post by xiphias2 »

snvzz wrote: post #7

If you hate aging (who doesn't), SENS Foundation[0] is dedicated to engineering solutions to reverse it. 0. https://www.sens.org/

People in SENS kicked out Aubrey de Gray for a ,,grooming” email and took over control of the donations that were sent because of him. I do not condone his previous action, but I also think that kicking him out to take over millions of dollars was not an unselfish action.

He is in the process of setting up a new foundation where I expect most of the new donations will flow.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#42

Post by slazaro »

elromulous wrote: post #37

I think at this point not putting "in mice" in an article title like this is just dishonesty.

I "yelled" IN MICE right after reading the title, went to check the article, and sure enough...

But yeah, it seems 100% deliberate because most people wouldn't probably care after reading the title. It's academic clickbait techniques.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#43

Post by adrian_b »

elromulous wrote: post #37

I think at this point not putting "in mice" in an article title like this is just dishonesty.

To be fair, there is little choice for any such study to be done on anything else but mice, because of their short natural lifespan.

Even if there were human volunteers willing to test on themselves various cocktails of chemicals, such a study would take many centuries.

Also on monkeys any study would take much too long.

So until aging in mice is well understood, any tests on monkeys or humans are pointless.

It is unlikely that the aging mechanisms differ in an essential way between mice and humans. If the aging in mice were understood, finding how it functions in humans would need far less work than for discovering how it functions in mice.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#44

Post by criddell »

Blammar wrote: post #17

Guess we'll figure out how to make mice immortal sometime soon, and sadly realize that the drug cocktail doesn't work on humans. Then the meek mice take over the earth as humanity dies off...

And dogs too!

https://dogagingproject.org/

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#45

Post by dsq »

I remember there being a lot of noise a few years ago about resveratrol, and how red wine (but only of a certain grape) was the secret to long life. What happens if you make the wrong decision and go all in, drinking wine and gobbling grape seeds, while it turns about to be something else entirely and you missed the boat? There’s no end to it, especially as there are only two real solutions that work, extreme caloric restriction and young blood transfusions(i.e a personal “blood boy”, humorously depicted in HBO’s Silicon Valley).

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#46

Post by herbst »

tomohawk wrote: post #38

I get why people are facinated by this sort of research, but pick your favorite nasty person, such as Putin, and consider what it would mean to radically extend their life. People in in Congress (an oxymoron) would be there even longer as they generally have to die to get kicked out. The longer they're there, the less they care about you and the more they'll care about their long lived fellow travelers.

Says more about the broken system(s) then the danger of long life's.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#47

Post by lambdafourtwo »

dsq wrote: post #45

I remember there being a lot of noise a few years ago about resveratrol, and how red wine (but only of a certain grape) was the secret to long life. What happens if you make the wrong decision and go all in, drinking wine and gobbling grape seeds, while it turns about to be something else entirely and you missed the boat? There’s no end to it, especially as there are only two real solutions that work, extreme caloric…

rapamycin triggers the same effect as extreme caloric restriction. Neither of the solutions you mentioned have been scientifically verified in humans.

Longevity research itself hasn't been around long enough to verify ANY longevity hypothesis on humans.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#49

Post by Eddy_Viscosity2 »

adrian_b wrote: post #43
elromulous wrote: post #37

I think at this point not putting "in mice" in an article title like this is just dishonesty.

To be fair, there is little choice for any such study to be done on anything else but mice, because of their short natural lifespan. Even if there were human volunteers willing to test on themselves various cocktails of chemicals, such a study would take many centuries. Also on monkeys any study would take much too long. So until aging in mice is well understood, any tests on monkeys or humans are pointless. It is un…

The problem wasn't that the study was done on mice, it was that this piece of information out was left out of the title. I agree with the OC that its deliberatively deceptive, unless of course this article was in 'The Journal of Mice' in which case it would be ok.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#50

Post by s1k3 »

dsq wrote: post #45

I remember there being a lot of noise a few years ago about resveratrol, and how red wine (but only of a certain grape) was the secret to long life. What happens if you make the wrong decision and go all in, drinking wine and gobbling grape seeds, while it turns about to be something else entirely and you missed the boat? There’s no end to it, especially as there are only two real solutions that work, extreme caloric…

If genuinely interested and not being tongue in cheek, there are a number of drugs and pathways that can be targeted to (in theory) extend lifespan in mammals. So as others have said- it may be that future therapies include a concoction of drugs and interventions to effectively increase lifespan in humans. If you’re curious about the subject Dr. David Sinclair does a lot content around this. He’s a researcher in the longevity field. He’s a little out there in terms of his personal beliefs but he does provide a lot of inform and context around all the current hot topics in longevity research.
Post reply on HN