Rapamycin is the word I keep hearing in 'health and wellness' communities online and on podcasts.
I think this guy is the most vocal about it
Combination of Rapamycin and Acarbose significantly Extends Lifespan
61–70 of 84 posts
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#62I get why people are facinated by this sort of research, but pick your favorite nasty person, such as Putin, and consider what it would mean to radically extend their life. People in in Congress (an oxymoron) would be there even longer as they generally have to die to get kicked out. The longer they're there, the less they care about you and the more they'll care about their long lived fellow travelers.
Says more about the broken system(s) then the danger of long life's.
What systems are not broken?
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#63To me it does look a bit comically like searching for the philosopher's stone as an ancient alchemist. If it's found within your natural lifetime you will be dead before the research is complete; by definition it will take longer than an average human lifespan. Mice only live a year so they are pretty quick and easy to study.
> If it's found within your natural lifetime you will be dead before the research is complete
I'm 30. If it takes another 30 years, I'll be 60. That's late, certainly, but I could still avoid a lot of health issues if I'm able to start taking something then. Most older people I know really start to degrade around their 70s and 80s, often after some sort of health incident or chronic issue crops up.
And if not, ok, well then some younger people in a generation or two will benefit and I'm happy for them.
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#64I remember there being a lot of noise a few years ago about resveratrol, and how red wine (but only of a certain grape) was the secret to long life. What happens if you make the wrong decision and go all in, drinking wine and gobbling grape seeds, while it turns about to be something else entirely and you missed the boat? There’s no end to it, especially as there are only two real solutions that work, extreme caloric…
If you were drinking red wine for resveratrol you were not doing much research.
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#65No post body was provided.
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#66I think at this point not putting "in mice" in an article title like this is just dishonesty.
To be fair, there is little choice for any such study to be done on anything else but mice, because of their short natural lifespan. Even if there were human volunteers willing to test on themselves various cocktails of chemicals, such a study would take many centuries. Also on monkeys any study would take much too long. So until aging in mice is well understood, any tests on monkeys or humans are pointless. It is un…
It is unlikely that the aging mechanisms differ in an essential way between mice and humans.
[citation needed]
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#67Earlier quoted context omitted.
To be fair, there is little choice for any such study to be done on anything else but mice, because of their short natural lifespan. Even if there were human volunteers willing to test on themselves various cocktails of chemicals, such a study would take many centuries. Also on monkeys any study would take much too long. So until aging in mice is well understood, any tests on monkeys or humans are pointless. It is un…
It is unlikely that the aging mechanisms differ in an essential way between mice and humans. [citation needed]
A citation is needed for the contrary statement.
Aging has appeared hundreds of millions of years ago in the ancestors of all multicellular animals and it manifests in the same way in most of them.
There is no known reason for aging in a way to be replaced by aging in some other way, like e.g. respiration through gills may be replaced by respiration through lungs, especially when we discuss some closely related mammals which have not diverged significantly in their way of life.
There are a few animal groups where more significant alterations in aging appears to have occurred, e.g. which have an unusually long lifespan, but whatever has changed seems to be restricted to those small groups.
There are no great divisions between animals where you could say that one group has a modified aging, like they might have a modified digestive system, enabling them to use a different food.
So until a contrary proof, the most plausible supposition is that aging happens in the same way in all multicellular animals, with minor differences, caused e.g. by more efficient cellular repair mechanisms in some of them, or by a "programmed death", i.e. suicide, which happens in many animals after reproduction, or in some colonial animals before a season when there will not be food for all of them.
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#68I remember there being a lot of noise a few years ago about resveratrol, and how red wine (but only of a certain grape) was the secret to long life. What happens if you make the wrong decision and go all in, drinking wine and gobbling grape seeds, while it turns about to be something else entirely and you missed the boat? There’s no end to it, especially as there are only two real solutions that work, extreme caloric…
rapamycin triggers the same effect as extreme caloric restriction. Neither of the solutions you mentioned have been scientifically verified in humans. Longevity research itself hasn't been around long enough to verify ANY longevity hypothesis on humans.
… in spite of being around for millennia.
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#69Earlier quoted context omitted.
To be fair, there is little choice for any such study to be done on anything else but mice, because of their short natural lifespan. Even if there were human volunteers willing to test on themselves various cocktails of chemicals, such a study would take many centuries. Also on monkeys any study would take much too long. So until aging in mice is well understood, any tests on monkeys or humans are pointless. It is un…
Your last point needs to be emphasized more. The core mechanism of aging is likely to be very similar across species as aging affect all tissues, organs, etc.
I think so too. And particular drugs that work in mice might not work in humans, but what those drugs tells us about aging in mice will help us understand aging in humans.
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#70Earlier quoted context omitted.
Rapamycin side effects don't look great tho: https://en.wikipedia.org/wiki/Sirolimus#Adverse_effects I prefer drugs that are: well-tolerated, cheap, already have a long history of use for conditions X, Y and Z, and then discovered as an off-label therapy (maybe in combination) for something else. As a heuristic it may not always work, but I think a good sign / rule-of-thumb might be "on the WHO list of essential medi…
You won't do it at the same doses as cancer treatment protocols . I've been doing rapa for my mood issues stemming from inflammation for some years now and low doses similar to the doses seen in recent studies for age longevity with no apparent side effects .
I know someone who played Russian Roulette once and is still alive. Getting lucky and risk taking have been best friends since the dawn of time.
Side effects don’t hit everyone and they don’t hit everyone the same. I’m on the absolutely lowest dose of a prescription drug because I react strongly to it. First dose had a really unpleasant side effect, lower dose got rid of that one but another developed later. It wasn’t particularly bad, I just found it upsetting. Lowest dose still gets most of the benefit without the side effects. For me. I know of someone with panic disorder who has a long list of drugs they can’t take at all because “feels funny” is enough to trigger an attack. We suspect vagus nerve issues of some sort.