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Combination of Rapamycin and Acarbose significantly Extends Lifespan

lifespan.io

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Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#51

Post by hombre_fatal »

graderjs wrote: post #20
hericium wrote: post #6

Previous links and discussions on Rapamycin and Metformin: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy [1] Rapamycin extends life span and health span of male mice and Daphnia magna [2] Drug typically used in cancer therapy emerges as potential anti-aging treatment[3] Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)[4] Metformin for cancer prevention,…

Rapamycin side effects don't look great tho: https://en.wikipedia.org/wiki/Sirolimus#Adverse_effects I prefer drugs that are: well-tolerated, cheap, already have a long history of use for conditions X, Y and Z, and then discovered as an off-label therapy (maybe in combination) for something else. As a heuristic it may not always work, but I think a good sign / rule-of-thumb might be "on the WHO list of essential medi…

Metformin doesn't look so hot either: https://www.science.org/content/article/rare-genital-defects...

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#52

Post by ck2 »

thornjm wrote: post #24
ck2 wrote: post #5

They've been studying Acarbose for awhile now https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789153/ The problem with a lot of these longevity approaches is they "solve the problem" by reducing energy conversion, like acarbose, pulling people to a baseline and preventing stress adaptations. Great for sitting around. The opposite of that for doing anything athletic, you'd never improve.

There is some evidence that "aerobic exercise" itself produces an equivalent baseline energy deficit without the performance downside. This guy[0] studies total average energy expenditure over time and demonstrates that an athlete undertaking intense regular exercise uses marginally more energy over time than someone sitting on a couch all day. The hypothesis being that the athlete is conserving energy by down-regula…

Exercise causes weight loss only in that as you want to get more fit you start watching what you eat, quality and quantity, more carefully.

As a lifelong runner I know I only burn 80 calories or less per mile, that's nothing.

However exercise does things that no supplement or drug can do, proper AMPK and cAMP activation, endorphin and endocannabinoid release.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#54

Post by Stevvo »

To me it does look a bit comically like searching for the philosopher's stone as an ancient alchemist. If it's found within your natural lifetime you will be dead before the research is complete; by definition it will take longer than an average human lifespan. Mice only live a year so they are pretty quick and easy to study.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#55

Post by snvzz »

xiphias2 wrote: post #41
snvzz wrote: post #7

If you hate aging (who doesn't), SENS Foundation[0] is dedicated to engineering solutions to reverse it. 0. https://www.sens.org/

People in SENS kicked out Aubrey de Gray for a ,,grooming” email and took over control of the donations that were sent because of him. I do not condone his previous action, but I also think that kicking him out to take over millions of dollars was not an unselfish action. He is in the process of setting up a new foundation where I expect most of the new donations will flow.

There was some drama[0], but did they really[1]?

I guess there's his twitter account[2]. Wow.

0. https://en.wikipedia.org/wiki/Aubrey_de_Grey#Sexual_harassme...

1. https://www.sens.org/about-us/leadership/

2. https://twitter.com/aubreydegrey

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#56

Post by JoshTko »

adrian_b wrote: post #43
elromulous wrote: post #37

I think at this point not putting "in mice" in an article title like this is just dishonesty.

To be fair, there is little choice for any such study to be done on anything else but mice, because of their short natural lifespan. Even if there were human volunteers willing to test on themselves various cocktails of chemicals, such a study would take many centuries. Also on monkeys any study would take much too long. So until aging in mice is well understood, any tests on monkeys or humans are pointless. It is un…

Your last point needs to be emphasized more. The core mechanism of aging is likely to be very similar across species as aging affect all tissues, organs, etc.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#57

Post by brigandish »

ramraj07 wrote: post #33
jokowueu wrote: post #32

Earlier quoted context omitted.

A large amount of rapa was bought during a group buy It was devided up between people who couldn't afford or get it To be clear its not specifically an anti cancer med it's an immune suppressant. It targets mtor so it's great for autoimmune disease The group I belong to specifically are people that have diseases that couldn't be treated either because of financial reasons or because docs wouldn't prescribe meds off l…

So no actual medical professionals involved. Got it. Please start your comments with that, though. You do you, but last I remember I’ve never seen a single person who desperately tried to live long actually live long.

I'm not sure why you didn't take the time to read the comment you replied to, but still, if we modify your statement a little:

> I’ve never seen a single person who desperately tried to live long actually live long

to I’ve never seen a single person who desperately tried to live longer actually live longer it changes from something you can't believe to a statement we know to be false because we see people achieving it every day, and that's what @jokowueu is attempting to do, and good luck to them.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#58

Post by amelius »

Stevvo wrote: post #54

To me it does look a bit comically like searching for the philosopher's stone as an ancient alchemist. If it's found within your natural lifetime you will be dead before the research is complete; by definition it will take longer than an average human lifespan. Mice only live a year so they are pretty quick and easy to study.

Or become a test subject and get lucky.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#59

Post by jeroenhd »

dsq wrote: post #45

I remember there being a lot of noise a few years ago about resveratrol, and how red wine (but only of a certain grape) was the secret to long life. What happens if you make the wrong decision and go all in, drinking wine and gobbling grape seeds, while it turns about to be something else entirely and you missed the boat? There’s no end to it, especially as there are only two real solutions that work, extreme caloric…

Whenever these immortality drugs come up, I always envision some kind of old, rich guy who dedicated his life to becoming rich, finding out that all that money won't buy you a second youth when it's already too late to do all the things he wanted to do. Multi millionaires getting rich, forgetting to live, and then focusing their wealth on a pipe dream of living long enough to spend all their money.

Ever since the first days of medicine, people have sought to prolong life. I think the entire quest is misguided and a waste of the medical field's resources; finding the cure for cancer and other horrible diseases should have priority on making some chosen few live to 100.

Even if the drug does work on humans without making life worse through side effects, I think the end result will be quite dystopic. You end up with a drug the rich can afford quite handily, while the poor will need to work their asses off for decades longer. Unless the drug is free, this will only serve benefit the top 1% of the planet and the pharmaceutical companies selling these drugs. As mankind struggles to accept mortality, the pool of workers will grow, led by drug companies telling them just a few decades years of hard work will surely make them rich.

Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan

#60

Post by kiawe_fire »

Reason077 wrote: post #21
Blammar wrote: post #17

Guess we'll figure out how to make mice immortal sometime soon, and sadly realize that the drug cocktail doesn't work on humans. Then the meek mice take over the earth as humanity dies off...

Presumably the mice would still need humans to keep producing the drugs that keep them immortal. But if immortality was a genetic trait passed on to their offspring then we’d be in trouble!

This future is oddly more comforting to me than Skynet.
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