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Guess we'll figure out how to make mice immortal sometime soon, and sadly realize that the drug cocktail doesn't work on humans. Then the meek mice take over the earth as humanity dies off...
Previous links and discussions on Rapamycin and Metformin: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy [1] Rapamycin extends life span and health span of male mice and Daphnia magna [2] Drug typically used in cancer therapy emerges as potential anti-aging treatment[3] Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)[4] Metformin for cancer prevention,…
My understanding is that Metformin's mortality reduction effect is only present in younger people. I don't have a source handy, but I take it for diabetes and was reading about its other positive effects a few years ago. Perhaps someone can chime in with additional information.
I can't recall the compound now, but I recall seeing something the other day about: "encounter with compound X just one time permanently strengthens immune system" or something. I think it was also in mice. I'm not even sure it was "immune system".
Also want to note that: our current pharmaceutical industry of (mostly) single molecule therapies is just one slice of the pie. In the future, we will probably have access to therapies that seem really sophisticated: not just "concoctions" (of multiple compounds in one therapy, which currently we are not sophisticated enough to explore sufficiently so the space of possible interactions that are therapeutic remains unknown); but also more "active" therapies, that include some vector (like virus, protein molecular machine, funghi, bacteria) that help to deliver / manufacture the therapy to just the right: time, location, amount our body needs.
And rather than being a specialized minority, they will be the majority. I think the space of molecules that are effective when delivered "systemically" is not as large or contains as many "silver bullet therapies" as the space of therapies that is effective when delivered precisely.
They've been studying Acarbose for awhile now https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789153/ The problem with a lot of these longevity approaches is they "solve the problem" by reducing energy conversion, like acarbose, pulling people to a baseline and preventing stress adaptations. Great for sitting around. The opposite of that for doing anything athletic, you'd never improve.
This guy[0] studies total average energy expenditure over time and demonstrates that an athlete undertaking intense regular exercise uses marginally more energy over time than someone sitting on a couch all day. The hypothesis being that the athlete is conserving energy by down-regulating baseline metabolic and inflammatory processes when at rest.
Disappointing news for "exercise causes dramatic weight loss" but encouraging news for "exercise is anti-cancer" (a correlation demonstrated many times I believe).
[0] https://www.science.org/content/article/scientist-busts-myth...
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Right. Some of these potential longevity interventions seem to have a catabolic effect. Not a problem if you're a mouse living in a safe, flat lab cage. But problematic for an elderly human at risk of falling down the stairs and breaking a hip due to sarcopenia.
Is it strong enough to actually cause that, or is it the kind of thing nonathletes won't notice? Or is the life extension effect too subtle to be relevant at all outside a flat mousecage?
Previous links and discussions on Rapamycin and Metformin: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy [1] Rapamycin extends life span and health span of male mice and Daphnia magna [2] Drug typically used in cancer therapy emerges as potential anti-aging treatment[3] Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)[4] Metformin for cancer prevention,…
Rapamycin side effects don't look great tho: https://en.wikipedia.org/wiki/Sirolimus#Adverse_effects I prefer drugs that are: well-tolerated, cheap, already have a long history of use for conditions X, Y and Z, and then discovered as an off-label therapy (maybe in combination) for something else. As a heuristic it may not always work, but I think a good sign / rule-of-thumb might be "on the WHO list of essential medi…
I've been doing rapa for my mood issues stemming from inflammation for some years now and low doses similar to the doses seen in recent studies for age longevity with no apparent side effects .
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Rapamycin side effects don't look great tho: https://en.wikipedia.org/wiki/Sirolimus#Adverse_effects I prefer drugs that are: well-tolerated, cheap, already have a long history of use for conditions X, Y and Z, and then discovered as an off-label therapy (maybe in combination) for something else. As a heuristic it may not always work, but I think a good sign / rule-of-thumb might be "on the WHO list of essential medi…
You won't do it at the same doses as cancer treatment protocols . I've been doing rapa for my mood issues stemming from inflammation for some years now and low doses similar to the doses seen in recent studies for age longevity with no apparent side effects .
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You won't do it at the same doses as cancer treatment protocols . I've been doing rapa for my mood issues stemming from inflammation for some years now and low doses similar to the doses seen in recent studies for age longevity with no apparent side effects .
Would be interested in your experience with fluorometholone eye drops. On-label for itchy eyes, but off-label seems to rapidly (onset ~ 60 seconds) reduce brain inflammation temporarily leading to mental quiet. Can't use too much tho as the steroid will dull the immune system in your sinuses increasing infection risk.
You can join the discord server run by joshua leisk and mention fluorometholone and I'll find you so we can see what might best work for you
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Rapamycin side effects don't look great tho: https://en.wikipedia.org/wiki/Sirolimus#Adverse_effects I prefer drugs that are: well-tolerated, cheap, already have a long history of use for conditions X, Y and Z, and then discovered as an off-label therapy (maybe in combination) for something else. As a heuristic it may not always work, but I think a good sign / rule-of-thumb might be "on the WHO list of essential medi…
You won't do it at the same doses as cancer treatment protocols . I've been doing rapa for my mood issues stemming from inflammation for some years now and low doses similar to the doses seen in recent studies for age longevity with no apparent side effects .