Combination of Rapamycin and Acarbose significantly Extends Lifespan
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Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#2[deleted]
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#3Please add the expected [in mice] mysteriously missing from the headline itself
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#4dose: mice were fed a diet containing 14 ppm rapamycin (mTOR antibiotic) and 1000 ppm acarbose (diabetes drug) for three months
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#5They've been studying Acarbose for awhile now
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789153/
The problem with a lot of these longevity approaches is they "solve the problem" by reducing energy conversion, like acarbose, pulling people to a baseline and preventing stress adaptations.
Great for sitting around. The opposite of that for doing anything athletic, you'd never improve.
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#6Previous links and discussions on Rapamycin and Metformin:
Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy [1]
Rapamycin extends life span and health span of male mice and Daphnia magna [2]
Drug typically used in cancer therapy emerges as potential anti-aging treatment[3]
Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)[4]
Metformin for cancer prevention, longevity: popular in Silicon Valley[5]
[1] https://news.ycombinator.com/item?id=32660669
[2] https://news.ycombinator.com/item?id=33058322
[3] https://news.ycombinator.com/item?id=32648886
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#7If you hate aging (who doesn't), SENS Foundation[0] is dedicated to engineering solutions to reverse it.
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#8They've been studying Acarbose for awhile now https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789153/ The problem with a lot of these longevity approaches is they "solve the problem" by reducing energy conversion, like acarbose, pulling people to a baseline and preventing stress adaptations. Great for sitting around. The opposite of that for doing anything athletic, you'd never improve.
What does that mean, preventing stress adaptations? Does it mean that the body wouldn’t get stronger in training ?
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#9Previous links and discussions on Rapamycin and Metformin: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy [1] Rapamycin extends life span and health span of male mice and Daphnia magna [2] Drug typically used in cancer therapy emerges as potential anti-aging treatment[3] Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)[4] Metformin for cancer prevention,…
My understanding is that Metformin's mortality reduction effect is only present in younger people. I don't have a source handy, but I take it for diabetes and was reading about its other positive effects a few years ago. Perhaps someone can chime in with additional information.
Re: Combination of Rapamycin and Acarbose significantly Extends Lifespan
#10Please add the expected [in mice] mysteriously missing from the headline itself
Props to the authors for choosing the subheader: "This effect was shown in mice."