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Ask HN: What interesting problems are you working on?

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Re: Ask HN: What interesting problems are you working on?

#92
Working on building a much simplified personal budgeting application. Been done to death, but usually not very well. What I'm making will put the simple and most straightforward aspects of budgeting front and center, and not try to boil the ocean with features. Mint is so convoluted now with all their credit and loan features that it no longer is useful for its actual purpose of budgeting.

Re: Ask HN: What interesting problems are you working on?

#93

Working on building a much simplified personal budgeting application. Been done to death, but usually not very well. What I'm making will put the simple and most straightforward aspects of budgeting front and center, and not try to boil the ocean with features. Mint is so convoluted now with all their credit and loan features that it no longer is useful for its actual purpose of budgeting.

A simple spreadsheet has been the perfect solution for me past few years.

Re: Ask HN: What interesting problems are you working on?

#94
1. Learning systems for patients with cognitive decline

2. AI writing tutors for middle schoolers

3. Paper-digital integration to support equitable education in India

4. Systematic review of resonance in human interactions

5. Computational models of beauty

6. Generating new Socratic dialogues by fine-tuning GPT3 with the complete works of Plato

7. Promoting ADD as a valid lifestyle choice

Re: Ask HN: What interesting problems are you working on?

#95

I heard few song lines from a new artist I've discovered. It has me thinking on a problem I want solved. Although, I'm not actively working on it. Why aren't there more employee-owned companies? And I don't mean solely shareholder programs, I mean actually owned by every employee and they are paid dividends of profit after all planned R&D costs. Similar to the Alaska oil pipeline bonus. Even interns. All studies show…

I am writing a book (The Software Mind) and am bouncing around the next stage of company formation. Democratic companies are such an obvious next stage.

Re: Ask HN: What interesting problems are you working on?

#96
I am working on video, but specifically trying to make it easier for anyone to “direct” their own content creatively without having to know all the technical skills for editing. Near to mid term is to try to use AI tech to enable this, though there’s actually a lot you can do even without that. My background is in developer tools (I was product director for CI/CD at GitLab) and so I am also trying to bring in the best from that experience around how to make hard stuff easy and difficult stuff at least possible.

I suspect there will be a lot of companies in the near future that make AI models with permissive licenses easier to use, along different niches (like I am doing for video). It is a really promising area and picking a niche helps with papering over the challenges with general models.

Re: Ask HN: What interesting problems are you working on?

#97
post #6

A little while ago, a patent for high throughput DNA synthesis using silicon chips went off-patent, so I have been learning analog IC chip design to build an open source high-throughput DNA synthesis chip. If it works, and I sold them at cost, it would reduce the cost of oligo pool synthesis by ~100x and possibly gene synthesis by 10x. For about 8-9 years now my goal has been to build a cell from scratch for less tha…

Not knowing anything about this field, what could someone do with such a chip?

Is it something like a 3D printer where you can get a rough but usable finished product, or is it more like a "if you want to make bacterium X produce Y product, you need to do X, Y, Z, W, etc." and the chip is used to do one of the steps.

Re: Ask HN: What interesting problems are you working on?

#98
post #6

A little while ago, a patent for high throughput DNA synthesis using silicon chips went off-patent, so I have been learning analog IC chip design to build an open source high-throughput DNA synthesis chip. If it works, and I sold them at cost, it would reduce the cost of oligo pool synthesis by ~100x and possibly gene synthesis by 10x. For about 8-9 years now my goal has been to build a cell from scratch for less tha…

How will you prevent people from using this technology to create DIY pathogens? If the answer is "I won't" or "it'll be open source, I won't be able to", consider doing something less harmful instead.

Synthesizing oligos is not the same thing as creating an infectious clone. This technology would be used to synthesize primers and custom promoter+gene fragments.

Re: Ask HN: What interesting problems are you working on?

#99
As always working on search.marginalia.nu.

Search itself is a fractal of interesting problems. Haven't had much time to write about it lately, but I've pretty much doubled the size of the index and re-written a lot of the query logic to make it much better, faster, and more accurate. Will do a write-up eventually, since it may be relatively explainable without getting too into the weeds that the audience dwindles entirely.

I keep having breakthroughs that make it in one way or another better, but as soon as I do I find something new that could be improved.

Kinda bonkers it's been possible to build this alone and run the entire thing on what amounts to a souped up PC :P

Re: Ask HN: What interesting problems are you working on?

#100
post #74

Earlier quoted context omitted.

What's your point? The technology already exists and is being used.

Your name, password, and the names and addresses and phone numbers and emails of all your family members already exist and are being used. So, by your logic, you have no reason to share them to everyone? The logic doesn’t hold up. You can make the same argument for anything. It makes sense to think about the dangers, not pretend that bad logic is an excuse to do anything you want.

No, actually your first sentence's logic doesn't hold up as it isn't a fair comparison at all. You can already order custom oligos and synthesized genes for relatively cheap. The chip idea would just reduce the cost more.
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