Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

age.mpg.de

Post reply on HN
Print view View original

201–210 of 228 posts

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#201

Post by funnym0nk3y »

jtbayly wrote: post #34
forgotmypw17 wrote: post #14

Earlier quoted context omitted.

A good measure is whether or not you feel that empty, churning feeling in your stomach. Another good measure is if you're into the idea of eating something like plain cabbage or oats.

I feel that after a few hours of not eating. Is feeling it or not feeling it the sign that I've reached the necessary effect?

I have no personal experience with this, so I must have read I somewhere. Usually in the first hours your get hungry, which eases off after some time. After that, you can until you are hungry again.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#202

Post by rewgs »

jonathan-adly wrote: post #113
BiteCode_dev wrote: post #103

Earlier quoted context omitted.

What makes me scared about this is that it's immunosuppressive. The immune system is a very important part of the human body, and I worry that taking it could have terrible health impact after years of acting on your body lines of defense. What can you tell me about it?

Your concern is correct. Suppressing the immune system is a 2-edged sword - a little suppression in the right setting, is extremely beneficial, but go overboard and it is harmful. That's why in a perfect world, we would have large human trials with different dosages and iterate until we can get the maximum benefit and the least harm. The problem is, no one wants to do those trials because rapamycin is cheap and gener…

> That's why in a perfect world, we would have large human trials with different dosages and iterate until we can get the maximum benefit and the least harm.

Off topic, but whenever I think about this, I find myself thinking that what the world really needs is next-level human/medicinal modeling. Imagine if human trials didn't have to happen in order to know the long-term effects (and in a fraction of the time)!

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#203

Post by ETH_start »

rewgs wrote: post #202
jonathan-adly wrote: post #113

Earlier quoted context omitted.

Your concern is correct. Suppressing the immune system is a 2-edged sword - a little suppression in the right setting, is extremely beneficial, but go overboard and it is harmful. That's why in a perfect world, we would have large human trials with different dosages and iterate until we can get the maximum benefit and the least harm. The problem is, no one wants to do those trials because rapamycin is cheap and gener…

> That's why in a perfect world, we would have large human trials with different dosages and iterate until we can get the maximum benefit and the least harm. Off topic, but whenever I think about this, I find myself thinking that what the world really needs is next-level human/medicinal modeling. Imagine if human trials didn't have to happen in order to know the long-term effects (and in a fraction of the time)!

I'm pretty sure AI could do this with enough data.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#204

Post by giantg2 »

quintushoratius wrote: post #192
jaggederest wrote: post #190

Earlier quoted context omitted.

One of the additives I work with in pottery is labeled with a prop 65 warning. The only ingredient is silicon dioxide, aka sand.

Which can lead to silicosis, which itself then leads to lung cancer.

This is also used as an anti-caking agent in food. Does CA label foods in that manner? Seems like it would cause confusion for the average consumer.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#205

Post by giantg2 »

rewgs wrote: post #202
jonathan-adly wrote: post #113

Earlier quoted context omitted.

Your concern is correct. Suppressing the immune system is a 2-edged sword - a little suppression in the right setting, is extremely beneficial, but go overboard and it is harmful. That's why in a perfect world, we would have large human trials with different dosages and iterate until we can get the maximum benefit and the least harm. The problem is, no one wants to do those trials because rapamycin is cheap and gener…

> That's why in a perfect world, we would have large human trials with different dosages and iterate until we can get the maximum benefit and the least harm. Off topic, but whenever I think about this, I find myself thinking that what the world really needs is next-level human/medicinal modeling. Imagine if human trials didn't have to happen in order to know the long-term effects (and in a fraction of the time)!

I'd imagine we'd have to have complete knowledge of the human body to completely replace human testing. There's a hell of a lot that we don't know, especially when it comes to why or how things work.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#206

Post by giantg2 »

LorenPechtel wrote: post #175
derefr wrote: post #159

Earlier quoted context omitted.

If you think about it, there are specific parts of our immune systems that are likely entirely maladaptive given modern civilization, where people are ~never exposed to parasites, animal venoms, etc. We can turn those parts off, while leaving everything else on, and be better for it (no allergies, psoriatic arthritis, MS, Chron’s, etc.; and so none of the accelerated cellular senescence those conditions provoke in af…

Exposure is uncommon, not basically never.

Exposure to toxoplasmosis is extremely common.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#207

Post by quanum_burrito »

I have taken this drug several times of the past 10 years. Each time it had a different effect on my immune system and body systems. The first attempt, it really helped with ridding my body of sustained fluid in my lungs. In more recent times it had helped with the same thing. I have a lung disease and it's not a simple thing to treat so they take care to treat it with some new treatments like rapamycin. I am simply stating that I had different and somewhat difficult times while being on the drug. The lung disease that I have is not common and I am immunocompromised, so being on an immunosuppressant drug like this really made me feel ill. I had the influenza A one year while being on it, as well as a couple of cases of pneumonia that put me into a funk. I am glad I was on it, though because it got me to where I need to be. The liquid form tastes disgusting( ya gonna need a chaser) but the pill is not so bad. It did really effect my joints and muscle systems, I was taking from 2 mg down to .5 mg and each time the doses made me feel extremely tired. I am glad that this med is helping people and I hope all that are taking it, are taking this medication seriously. It is no easy task to be on. Drink lots of water. Best wishes

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#208

Post by derefr »

LorenPechtel wrote: post #175
derefr wrote: post #159

Earlier quoted context omitted.

If you think about it, there are specific parts of our immune systems that are likely entirely maladaptive given modern civilization, where people are ~never exposed to parasites, animal venoms, etc. We can turn those parts off, while leaving everything else on, and be better for it (no allergies, psoriatic arthritis, MS, Chron’s, etc.; and so none of the accelerated cellular senescence those conditions provoke in af…

Exposure is uncommon, not basically never.

Depends on where you live.

For the average human on Earth: sure, merely uncommon.

For the average person who lives in a city and rarely goes out into nature, and paranoid-ly avoids doing things like walking barefoot in dung or wearing shortsleeves in forests when they do: effectively never.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#209

Post by mlinksva »

https://rapamycinstudy.org/ is collecting data on off-label use according to https://www.fightaging.org/archives/2022/04/collecting-data-... (reasonatllm who runs that site hasn't commented on this site recently, perhaps they are busy running https://www.repairbiotechnologies.com/)

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#210

Post by tsol »

ETH_start wrote: post #203
rewgs wrote: post #202

Earlier quoted context omitted.

> That's why in a perfect world, we would have large human trials with different dosages and iterate until we can get the maximum benefit and the least harm. Off topic, but whenever I think about this, I find myself thinking that what the world really needs is next-level human/medicinal modeling. Imagine if human trials didn't have to happen in order to know the long-term effects (and in a fraction of the time)!

I'm pretty sure AI could do this with enough data.

I'm sure. But it's data we don't even have right now. We don't even know every chemical that naturally occurs in the body, how are we supposed to predict how they could interact with novel chemicals? Some day, though, it may be possible. There was a point where people couldn't imagine these image generation AIs working
Post reply on HN