Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy • Hacker News Board

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#161

Post by webnrrd2k » Wed, Aug 31, 2022, 6:29 PM UTC

jonathan-adly wrote: post #113

BiteCode_dev wrote: post #103

Earlier quoted context omitted.

What makes me scared about this is that it's immunosuppressive. The immune system is a very important part of the human body, and I worry that taking it could have terrible health impact after years of acting on your body lines of defense. What can you tell me about it?

Your concern is correct. Suppressing the immune system is a 2-edged sword - a little suppression in the right setting, is extremely beneficial, but go overboard and it is harmful. That's why in a perfect world, we would have large human trials with different dosages and iterate until we can get the maximum benefit and the least harm. The problem is, no one wants to do those trials because rapamycin is cheap and gener…

Why don't insurance companies fund some of this research? Honestly, I don't know.

Wouldn't they want to get treatment costs down? Large HMOs, especially, have motivation to control treatment costs, and access to the patients, data, etc... to make it work.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#162

Post by enviclash » Wed, Aug 31, 2022, 6:32 PM UTC

If it is a reliable alternative to a medicine with similar effects, I advocate for fasting. I try doing it once per week until 2pm, and once per month till dinner. At some point (years in my case) it became a pleasure.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#163

Post by JumpCrisscross » Wed, Aug 31, 2022, 6:33 PM UTC

wang_li wrote: post #140

JumpCrisscross wrote: post #104

Earlier quoted context omitted.

> wouldn't call protein breakdown in the muscle "wasting" without additional effects Fair enough, given it's voluntary [1]. It's biologically identical to wasting, however. [1] https://en.wikipedia.org/wiki/Wasting

There's some evidence that exercising during the fast helps minimize the loss of muscle.

> some evidence that exercising during the fast helps minimize the loss of muscle

The original point was autophagy reactivates mTOR. This isn’t a linear system. It could be that a 20-hour fast downregulates mTOR more than a 30-hour fast. (We know it works at 72 hours.)

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#164

Post by GordonS » Wed, Aug 31, 2022, 6:35 PM UTC

ltbarcly3 wrote: post #148

phkahler wrote: post #72

Earlier quoted context omitted.

>> The drug has been known for a long time but human trials always seems elusive Human trials of this will likely never happen. At least not publicly.

Why is that? Literally nobody will do the research in any country in the world because the Illuminati are everywhere?

Money and perverse incentives.

Clinical trials are expensive, and rapamycin can't be patented. My guess is that, some time in the future, a pharma company will produce and patent an analogue, and then there will be trials.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#165

Post by cbozeman » Wed, Aug 31, 2022, 6:45 PM UTC

Traubenfuchs wrote: post #78

pstuart wrote: post #69

Earlier quoted context omitted.

Finding a doctor who's up to "non-traditional" support can be a challenge, but you've inspired me to start that search.

Besides satisfying their altruism they have nothing to gain and everything to lose if this miracle drug causes cancer in 5 years. I read up ok it. It can literally cause cancer.

Depending on where you are, everything can cause cancer.

This website is known to the State of California to cause cancer.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#166

Post by deegles » Wed, Aug 31, 2022, 6:51 PM UTC

WastingMyTime89 wrote: post #156

deegles wrote: post #127

I'm 35, have been taking 6mg of rapamycin per week for about a year. It's hard to assign the effects directly to it since I've been taking other supplements and also fixing up my diet + exercise. That being said, I am quite sure that it has reduced general aches and pains, reduced visceral fat and I now have less gray hair compared to when I started. It did slightly increase my glucose and lipids, but still within sa…

This comment is quintessential to the issue with HN. So you are quite young, just had a complete change of lifestyle and your take away is that the beneficial effect comes from the drug you take randomly amongst a cocktail of other things. Interesting.

It was not a "complete change" in lifestyle. Please don't make assumptions beyond what is written.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#167

Post by WastingMyTime89 » Wed, Aug 31, 2022, 6:53 PM UTC

deegles wrote: post #166

WastingMyTime89 wrote: post #156

Earlier quoted context omitted.

This comment is quintessential to the issue with HN. So you are quite young, just had a complete change of lifestyle and your take away is that the beneficial effect comes from the drug you take randomly amongst a cocktail of other things. Interesting.

It was not a "complete change" in lifestyle. Please don't make assumptions beyond what is written.

> fixing up my diet + exercise

That’s definitely a complete change in lifestyle. Sorry but not sorry.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#168

Post by swayvil » Wed, Aug 31, 2022, 7:03 PM UTC

atdrummond wrote: post #126

chimen wrote: post #98

Earlier quoted context omitted.

[1] - "The figures are staggering: out of 35,000 children in care, more than 2,000 were physically or sexually abused by priests between 1936 and 1999" (Ireland alone) [2] - French Church abuse: 216,000 children were victims of clergy - inquiry 1. https://www.justiceinfo.net/en/45133-sexual-abuse-church-map... 2. https://www.bbc.com/news/world-europe-58801183

I saw no indication he was promoting the Church, rather than belief in G-d. (Not that it was a relevant reply anyway.)

He's referring to an apparent ubiquitous progressive corruption. Individual and social.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#169

Post by swayvil » Wed, Aug 31, 2022, 7:08 PM UTC

isoprophlex wrote: post #47

swayvil wrote: post #15

What's the latest on bloodboys? That is : periodic blood transfusion from healthy young vegan donor. It works very well. Rejuvenates ancient billionaires. Surely it's superpopular among the oligarchs. Probably not the kind of thing you want in the news (vampires!). The technical term is Parabiosis . These guys offer the service : https://www.ambrosiaplasma.com/

Every day we stray further from god's light

As evil goes it's pretty mild.

It could be much worse. The bloodboy might pursue a career in advertising.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#170

Post by 4gotunameagain » Wed, Aug 31, 2022, 7:15 PM UTC

mtlmtlmtlmtl wrote: post #88

swayvil wrote: post #15

What's the latest on bloodboys? That is : periodic blood transfusion from healthy young vegan donor. It works very well. Rejuvenates ancient billionaires. Surely it's superpopular among the oligarchs. Probably not the kind of thing you want in the news (vampires!). The technical term is Parabiosis . These guys offer the service : https://www.ambrosiaplasma.com/

It's so strange to me that is is legal in the US when prostitution isn't(in most states). Not that I think prostitution should be illegal, but it's basically the same thing.

You are talking about a country that you can drive when you are 16 but drink when you are 21, and buy a rifle but not a kinder egg.