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Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

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Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#71

Post by pstuart »

derbOac wrote: post #52

Maybe I missed this, but 2 weeks in fruit flies and 3 months in mice probably translates into something much longer in humans, on the order of a year or two maybe, if not longer? That's a pretty long time to be on an immune-suppressing drug with pretty significant side effects. It's still an important bit of information if it replicates, but I think it might not be as clinically practical as it sounds from the press…

Not just the quantity of extended time, but the quality of that time matters too. Even if life wasn't extended a day but one had greater vigor/vitality/cognition it would still likely be a worthy pursuit.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#72

Post by phkahler »

rdedev wrote: post #67

After reading the following article I've tempered my expectations from ramapycin https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-... The drug has been known for a long time but human trials always seems elusive

>> The drug has been known for a long time but human trials always seems elusive

Human trials of this will likely never happen. At least not publicly.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#73

Post by mrandish »

Tepix wrote: post #6
orangepurple wrote: post #4

The bigger story with rapamycin is that the mechanistic target of rapamycin (mTOR) plays an absolutely crucial role in major diseases of modern civilization. One of the ways to inhibit mTOR for free is to simply stop consuming nutrients for extended periods of time.

> ... to simply stop consuming nutrients for extended periods of time That is not simple for most people.

True but after I went very low-carb, I found fasting to be much easier when it had always been very hard for me previously. I know it's more complicated than "carbs cause hunger pangs ~8 hrs later" but my N=1 experience sure feels that way.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#75

Post by MisterTea »

orangepurple wrote: post #32
chrisweekly wrote: post #7

Earlier quoted context omitted.

simple != easy

Agree; it was very painful initially and not easy. But very simple conceptually!

I did caloric restriction for a year and eased into it gradually until I was eating two small meals a day. I had no ailments but weighed upward of 230 lbs, 104kg. In a year I went down to near zero body fat and weighed 150lbs/68kg. Unfortunately for my build and frame that made me look sickly so I started eating again and Ive settled around 165 and working to put on a little muscle. Overall I'd say I did this whole thing over two years without much effort. Though yes, getting over the hunger pangs is very hard but once over them you quickly learn to ignore them.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#76

Post by JumpCrisscross »

orangepurple wrote: post #31
JumpCrisscross wrote: post #28

Earlier quoted context omitted.

> ways to inhibit mTOR for free to simply stop consuming nutrients for extended periods of time How frequently and for how long must one fast to see this?

As long as you can bear it. Which for me has been 24 +/- 4 hours between meals for 9 months and counting.

> long as you can bear it

This gives zero evidence a threshold has been reached for enzyme activation.

There is evidence of effects after 72 hours of fasting [1]. But we also know of counter-effects around 24 hours, when glucose released by the liver breaking down amino acids from muscle wasting (EDIT: autophagy) partially reactivates mTOR [2]. It could be massive or minimal benefits through 24 hours, we don't know, benefits which reduce between 24 hours and some other number, and then increase until, or until right before or well through 72 hours.

[1] https://journals.plos.org/plosone/article?id=10.1371/journal...

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390257/?_escap...

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#77

Post by fayalargeau »

adamgordonbell wrote: post #56

Anyone taking or have taken Rapamycin or things that change mTor? How did that go? Is there risk of infections? David Sinclair got me interested in this topic. Also people who fast for a long time: How do you do that? I get super hangry and find it really a struggle past a certain point of not eating.

that was my favorite podcast, but he did say that he stays away from it because it's meant for people who need it as an immunosuppresant

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#78

Post by Traubenfuchs »

pstuart wrote: post #69
evo_9 wrote: post #63

I'm a month into taking rapa and already I feel like it's having a noticeable effect. I'm curious what others on this threads dosage looks like. If you prefer to keep it private, you can email me directly (my email is on my profile). I'm currently taking 2mg once a week on my rest day; I started with 1mg and after 1 month added another MG. I'll continue each month until I reach 8MG once a week, which is the dosage th…

Finding a doctor who's up to "non-traditional" support can be a challenge, but you've inspired me to start that search.

Besides satisfying their altruism they have nothing to gain and everything to lose if this miracle drug causes cancer in 5 years.

I read up ok it. It can literally cause cancer.

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#79

Post by shiftpgdn »

yasp wrote: post #74

FYI one study shows that rapamycin increases amyloid-beta protein plaques in the brains of mice. https://neurosciencenews.com/rapamycin-amyloid-beta-20770/

All of the original data around amloyd-beta protein data was faked. A lot of it was even just outright photoshopped. https://www.science.org/content/blog-post/faked-beta-amyloid...

Re: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

#80

Post by yazaddaruvala »

kubami wrote: post #65
adamgordonbell wrote: post #56

Anyone taking or have taken Rapamycin or things that change mTor? How did that go? Is there risk of infections? David Sinclair got me interested in this topic. Also people who fast for a long time: How do you do that? I get super hangry and find it really a struggle past a certain point of not eating.

I fast a lot, right now I do 36 - 72h every 6 - 8 weeks. The hardest moment is right when your body is about to switch from using glucose to using ketone bodies for energy. After that the hunger, feeling anxious, etc stops. The time it takes to get to that point (when feeling "bad" intensifies) and how long the transition takes can be influenced. Primarily, by what you eat before you fast. In general, avoid eating ca…

Oh I forgot about the tricks. Thanks.

I also use the tricks mentioned above. They are very useful.

Additional tricks:

- Use fiber supplements in your water sometime in the middle of your fast (simplest time is in the morning in lieu of breakfast). I use psyllium husk.

- Soup (or rather broth) is a fasting bff. Remember miso, herbs, spices, salt, do not have calories. Flavor your water liberally. Change up the consistency with stuff in it (green onions, seaweed). Change up the temperature (hot, cold, whatever). I even add psyllium husk to my soups to change up the texture and consistency just for the variety. Remember you can “eat” a lot of tasty stuff while still technically fasting.

- Actively (rather than passively) deplete your glycogen stores. Do a workout ideally including cardio, then do your best to immediately fall asleep to recover. I can sleep through anything, if you can too you’ll be in keto by the morning and no real feelings of difficulty.

- Remember to take a multi-vitamin daily while fasting. Make sure it doesn’t have sugar like those “vitamin C hangover powders” or “electrolyte water stuff like Gatorade”.

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