101–110 of 228 posts
FYI one study shows that rapamycin increases amyloid-beta protein plaques in the brains of mice. https://neurosciencenews.com/rapamycin-amyloid-beta-20770/
All of the original data around amloyd-beta protein data was faked. A lot of it was even just outright photoshopped. https://www.science.org/content/blog-post/faked-beta-amyloid...
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> ... to simply stop consuming nutrients for extended periods of time That is not simple for most people.
This is Hackernews. The cure is fasting. Whatever disease you have, the cure is fasting.
Just putting this out there, I am a PharmD and this is totally real and the traditional medical establishment is really behind. It is positive effects are beyond doubt - the argument against it is usually "we don't know what the side effects if 100m+ went on it for 20+ years". (which is also 100% true, but that's where patient autonomy comes in). Also, there are some questions about how much are really the positive e…
What can you tell me about it?
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> long as you can bear it This gives zero evidence a threshold has been reached for enzyme activation. There is evidence of effects after 72 hours of fasting [1]. But we also know of counter-effects around 24 hours, when glucose released by the liver breaking down amino acids from muscle wasting (EDIT: autophagy) partially reactivates mTOR [2]. It could be massive or minimal benefits through 24 hours, we don't know,…
I wouldn't call protein breakdown in the muscle "wasting" without additional effects
Fair enough, given it's voluntary [1]. It's biologically identical to wasting, however.
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This is Hackernews. The cure is fasting. Whatever disease you have, the cure is fasting.
And somehow the answer to "how did it make you healthier?" is almost always just weight loss or effects related to weight loss.
Changes in one's perception of local stimuli and focus abilities are almost impossible to convey to others.
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And somehow the answer to "how did it make you healthier?" is almost always just weight loss or effects related to weight loss.
Just like you wouldn't grasp the incredibility of an acid trip unless you did one yourself. Changes in one's perception of local stimuli and focus abilities are almost impossible to convey to others.
Anyone taking or have taken Rapamycin or things that change mTor? How did that go? Is there risk of infections? David Sinclair got me interested in this topic. Also people who fast for a long time: How do you do that? I get super hangry and find it really a struggle past a certain point of not eating.
I fast a lot, right now I do 36 - 72h every 6 - 8 weeks. The hardest moment is right when your body is about to switch from using glucose to using ketone bodies for energy. After that the hunger, feeling anxious, etc stops. The time it takes to get to that point (when feeling "bad" intensifies) and how long the transition takes can be influenced. Primarily, by what you eat before you fast. In general, avoid eating ca…
Sometimes I can approach 48 hours before I start to feel bad, other times I can't even make it one day before I'm a mess and can hardly function. I'm sure the difference has to do with blood sugar timing and/or what I ate the day before or something.
I wonder what happens if someone overdosed in anti-ageing drug, do they turn into baby.
genuine question: why would someone want to live longer than the average? Edit: I ask because I personally don't see a reason to stay alive while people I love are dying, I don't see a reason to stay alive in an already fucked up planet, while we empty all the resources, etc. But you guys are so smart, intelligent and clever, why even bother.
Because I'm so "so smart, intelligent and clever" and the alternative is unknown to me. Simple 1+1