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New antibody neutralizes all known SARS-CoV-2 variants in lab tests

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Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#41
post #9
post #8

Earlier quoted context omitted.

Reducing the spread of existing variants reduces the number of replications the virus can make, which in turn reduces the occurrence of mutations.

But it is always going to continue to spread won’t it? A vaccine may slow it down which is good but my fear is that long term non-live vaccines like this could just make things worse when used with such a volatile virus.

Precisely the reverse: attenuated virus (live virus) vaccines regularly allow mutation back to pathological forms. See: polio. This is because an attenuated virus is still replicating viral particles and every replication is a lottery ticket that the virus might mutate back.

mRNA vaccines, by contrast, causes no viral replication so the virus doesn't get these lottery tickets.

Of course, either type of vaccine is going to place evolutionary pressure on a disease to evolve an escape. That's just what happens.

One side note: one of the things about mRNA vaccines is that they can be very specific. Now, that may not be great for Covid where we would like to be more general. However, that may be absolutely essential against Epstein-Barr where a chunk of the virus looks like nervous system proteins. A standard vaccine is likely to prime the immune system just like the virus and cause multiple sclerosis as a side effect. An mRNA vaccine, by contrast, could target only those sections of the E-B virus that look sufficiently different from the nervous system and prime the immune system without risking friendly fire.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#42

From the article: The researchers have applied for patents on both the antibodies and the mouse model used to produce them. They hope to see their work developed commercially. ... followed by This work was supported by the Howard Hughes Medical Institute, the Bill & Melinda Gates Foundation (INV-021989), the National institutes of Health (NIAID Consortia for HIV/AIDS Vaccine Development UM1-AI144371, P01 AI158571, Ma…

[deleted]

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#44
post #7

Can anyone with more knowledge on this topic than me (I’m no expert) assuage my fears: by giving human populations such artificial resistances (non-live vaccines) we run the risk of selecting for viruses that are even harder for even our own immune systems to detect and destroy. Current Covid strains don’t seem all that bad, basically everyone I know has been infected now. Might we run the risk of making things worse…

> by giving human populations such artificial resistances (non-live vaccines) we run the risk of selecting for viruses that are even harder for even our own immune systems to detect and destroy

I can put your fears to bed. That shouldn't happen. How vaccines work is they teach a very specific signature to our bodies so it can be destroyed as soon as it appears. . Therefore, any selection pressure would just be to not have that signature. But, since that signature is only valuable because it is recognized, there's no great loss if it becomes meaningless. So no supervirus issues. This is different from overusing antibiotics, because the selection there is not on signatures, but instead a more general "robustness" to the poison (well, poison to the bacteria).

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#45

From the article: The researchers have applied for patents on both the antibodies and the mouse model used to produce them. They hope to see their work developed commercially. ... followed by This work was supported by the Howard Hughes Medical Institute, the Bill & Melinda Gates Foundation (INV-021989), the National institutes of Health (NIAID Consortia for HIV/AIDS Vaccine Development UM1-AI144371, P01 AI158571, Ma…

Alternatively, why don't researchers just take investment in place of grants?

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#46
post #32

From the article: The researchers have applied for patents on both the antibodies and the mouse model used to produce them. They hope to see their work developed commercially. ... followed by This work was supported by the Howard Hughes Medical Institute, the Bill & Melinda Gates Foundation (INV-021989), the National institutes of Health (NIAID Consortia for HIV/AIDS Vaccine Development UM1-AI144371, P01 AI158571, Ma…

I think it would make a lot of sense if "any patents arising from research done with monies given by will confer on a lifetime perpetual non-exclusive right to use and re-license said patent on what ever terms they deem acceptable." If this were implemented, wouldn't it just be the case that no one would take your money?

Perhaps, I haven't been personally involved in a university lab looking for grant money so I don't know if they would turn down a grant if it required that any patentable work be also licensed to the grantor organization.

And to be clear, I don't expect this situation to change any time soon. Just annoyed by it.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#47
post #16

Earlier quoted context omitted.

I'm going to wait for actual careful human testing .... could be that 5% of the human (but not mouse) population have a variant of some critical metabolic path that this anti-body attacks ..... But yes, once we know it's safe sign me up too

Did you follow this safety protocol with the current covid vaccines?

Everyone did. The COVID vaccines were developed in like a month. The rest of that time was careful human testing.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#48
post #5

Hopefully this proves to be effective -- and hopefully it doesn't merely encourage this particular binding site to mutate more rapidly.

I was under the impression that we can mutate it into a corner because there are only so many shapes it can mutate into before it doesn't work and the virus can't get into cells.

I'm not sure about that. There are probably hundreds or thousands of still-viable mutations it might come up with at random, and we don't want to inject dozens of vaccine candidates to deal with them. Or maybe we do? A lot of adults have probably had a dozen or two dozen varying flu shots.

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#49
post #40

From the article: The researchers have applied for patents on both the antibodies and the mouse model used to produce them. They hope to see their work developed commercially. ... followed by This work was supported by the Howard Hughes Medical Institute, the Bill & Melinda Gates Foundation (INV-021989), the National institutes of Health (NIAID Consortia for HIV/AIDS Vaccine Development UM1-AI144371, P01 AI158571, Ma…

Why would Pfizer drop a few billion on getting the vaccine to market if the funders would then relicense it?

Because they could make more than $XB by selling it afterwards?

Also, who's to say that Pfizer can't make an additional deal, or funding, for this effort?

Re: New antibody neutralizes all known SARS-CoV-2 variants in lab tests

#50
post #36
post #20

Earlier quoted context omitted.

Evolution is climbing mount improbable. And natural selection (even in the face of in this case intelligently designed selectors) funnels organisms into potential dead ends which they can’t evolve out of - they’ve gone up the ‘north face’ and in order to reach fitness in the face of their selectors, they actually need to be on a completely different mountain. An antibody that dead ends all current evolutionary trends…

How are we sure it is a dead end and how sure are we? It sounds as if this would put extraordinary selective pressures on the virus, if we are wrong I’d fear we would just make things worse

Well if it isn't then you just make other antibodies that treat the one that you can't deal with. Like it's a dead end at current time with current understanding. And as for making things worse, well it could or it could make things better by becoming lesser variant.
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