151–160 of 303 posts
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How do you define "psychoactive"?
This is so disingenuous. Psilocybin directly affects levels of different neurotransmitters in the brain. Aspirin is an anti inflammatory.
I'm sort of surprised they didn't extract/synthesize psilocybin directly and administer that. Decades ago, I grew a few batches of P. Cubensis. Even amongst mushrooms from the same rice cake, the dosage wildly varies. You could have a "trip" from a tiny mushroom or eat a handful of duds.
This is the main reason with psychoactive mushrooms overall. You can't dose exact via bio material so overdosing happens regular and could be actually harmful.
Been doing it for some months on & off, this shit is legit. Altough 0,5g has me tripping so I rarely dose above 100 milligrams. Get up early, do a workout, take cold shower, meditate and then pop a microdose shrooms, feels great. Microdosing is like steroids for meditation. Especially helpful for the programmer logic types of people like me, gets you out of your head for some time and helps you connect with your emot…
> Been doing it for some months on & off, this shit is legit The linked study seems to contradict you: >> According to our findings, low doses of psilocybin mushrooms can result in noticeable subjective effects and altered EEG rhythms, but without evidence to support enhanced well-being, creativity and cognitive function. We conclude that expectation underlies at least some of the anecdotal benefits attributed to mic…
Microdosing is great but not for everyone. It can actually increase your anxiety if you take too high a dose. Personally, I take a micro dose of LSD every other Friday, drink a cup of coffee and hit the gym. It does wonders. And definitely not addicting.
/jealous.
Been doing it for some months on & off, this shit is legit. Altough 0,5g has me tripping so I rarely dose above 100 milligrams. Get up early, do a workout, take cold shower, meditate and then pop a microdose shrooms, feels great. Microdosing is like steroids for meditation. Especially helpful for the programmer logic types of people like me, gets you out of your head for some time and helps you connect with your emot…
Yeah, drugs feel great, news at 11. If psychiatry was just a matter of giving people a constant buzz, it would be solved a century ago. I'm not judging you for wanting to be high all the time, I've been there myself. But be intellectually honest and call it that, at least. Because it's not some kind of psychological panacea, and I wish people would stop implying it is. And yes, I've tried it. It made me high, but gen…
If it made you high, you didn't microdose.
(It's strange that we're using the term microdose, even in scientific contexts - prefixes have meanings - it should be called a decidose.) Anecdotally, I've had a degree of short term success treating my depression with smallish doses of mushrooms, but I've never had the continuing access required for a microdosing regiment. It'd be nice if the government were willing to come to the table on this, but alas. That said…
Why do you want to change your condition with a thing, when the answer is inside you?
Anecdotally in the past I have felt major differences in my mood right after and over the next few months since after taking mushrooms containing psilocybin (liberty caps locally picked growing in nature). The quantity was anything but microdoses though. Each time I had them the amount ranged from 6x to 10x individual dried caps (over a period of 4-5 hours each time). I'm not sure about its impact on my creativity th…
It's not clear what you mean here? I've taken magic mushrooms quite a few times, and it definitely had an impact on negativity right after and for many weeks. For me, negativity was down regulated . This might not be true of everyone's experience though.
In studies such as these with huge intersubject variability, and probably also quite large intrasubject variability from day to day on many scales, it makes sense to look at change from baseline for individuals in the various groups rather than just differences in raw scores between treatment groups. It seems by a cursory glance that most analyses done were of the latter kind, and I think then a study such as this, w…
That’s called cherry picking. Results are always noisy. You could give two groups of people the same tests on different days without any drugs at all and some subset would show “improvement”. If you start focusing on the individuals that show the result you want to see, you cherry-pick your way into false results.
This is a well-known way for researchers to abuse variable or noisy data sets to misleadingly show the result they want to show.
> I am almost certain that e.g. none of the approved and quite convincingly working SSRI:s would have shown any efficacy in a study with this design and similar N.
Thats not true. SSRI studies with ~30 people will show a trend toward improvement in the SSRI group that exceeds the placebo group. I think you’re confusing the different statistical measures.
This study showed that expectations and placebo effect were the predictor of micro-dosing success. The blinded group and unblinded group showed completely different results.
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Can confirm, especially mushrooms. I had one trip on them and what my main take away was: It's exhausting to trip on mushrooms and after 4-5 hours I wanted to be sober again. I'll probably do it again in a few month but for me it's a whole-weekend kind of deal and hardly a party drug
my main issue with mushrooms is how nauseous i get -- also, i lose all my appetite for at least 12h (last time, it took 24h for me to be actually hungry again).
what are you eating the day beforehand / how is your diet in general? (like, lots of greasy, heavy food the day before / day of, or more on the lighter, healthier side of things?) this can really impact a body’s response to mushrooms on a gastrointestinal level.
those being more fundamental, I would say - but on top of that, could consider a hot-water infusion with anti-emetic herbs like ginger. tends to be smoother on the GI (provided you haven’t filled your stomach contents as way as well). tends to come on more quickly as well.
something else to consider is that gastrointestinal distress with psilocybin can be an indication of unprocessed emotional material and / or trauma. there’s different ways to work with that, in that context.