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Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

nature.com

31–40 of 303 posts

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#32

Been doing it for some months on & off, this shit is legit. Altough 0,5g has me tripping so I rarely dose above 100 milligrams. Get up early, do a workout, take cold shower, meditate and then pop a microdose shrooms, feels great. Microdosing is like steroids for meditation. Especially helpful for the programmer logic types of people like me, gets you out of your head for some time and helps you connect with your emot…

Yeah, drugs feel great, news at 11. If psychiatry was just a matter of giving people a constant buzz, it would be solved a century ago. I'm not judging you for wanting to be high all the time, I've been there myself. But be intellectually honest and call it that, at least. Because it's not some kind of psychological panacea, and I wish people would stop implying it is. And yes, I've tried it. It made me high, but gen…

That's an uncharitable reading. OP is just sharing what works with her/him. Which is ok. From what I understood from your comment, for you it doesn't. Which is ok too, as now you know yourself a bit better. Two personal experiments with very different outcomes. There's no need for moral judgments either way.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#34

Earlier quoted context omitted.

Microdose = sub-perceptual dose Threshold dose = dose at which effects can barely be perceived Low dose = dose at which effects become definitely perceptible The people in this study were taking something between a threshold dose and a low dose, given some interpersonal variability.

.5 is definitely a low dose for anyone who has experienced it more than a few times or an actual low dose at least once. Realistically, I'd expect only a first timer could possibly think .5 is imperceptible.

[deleted]

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#35

Been doing it for some months on & off, this shit is legit. Altough 0,5g has me tripping so I rarely dose above 100 milligrams. Get up early, do a workout, take cold shower, meditate and then pop a microdose shrooms, feels great. Microdosing is like steroids for meditation. Especially helpful for the programmer logic types of people like me, gets you out of your head for some time and helps you connect with your emot…

Yeah, drugs feel great, news at 11. If psychiatry was just a matter of giving people a constant buzz, it would be solved a century ago. I'm not judging you for wanting to be high all the time, I've been there myself. But be intellectually honest and call it that, at least. Because it's not some kind of psychological panacea, and I wish people would stop implying it is. And yes, I've tried it. It made me high, but gen…

I get what you’re saying, but I think the GP may see being less productive as a positive thing (productivity not being a universal value)

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#36

Earlier quoted context omitted.

Yeah, drugs feel great, news at 11. If psychiatry was just a matter of giving people a constant buzz, it would be solved a century ago. I'm not judging you for wanting to be high all the time, I've been there myself. But be intellectually honest and call it that, at least. Because it's not some kind of psychological panacea, and I wish people would stop implying it is. And yes, I've tried it. It made me high, but gen…

Trust me I tried all kinds of drugs and psychedelics are not the kind that get you hooked. Stimulants are especially addictive in my opinion. Psychs are the kind of drugs you say I have enough for a while if you overdo. On top of it they build tolerance immediately.

Can confirm, especially mushrooms. I had one trip on them and what my main take away was: It's exhausting to trip on mushrooms and after 4-5 hours I wanted to be sober again. I'll probably do it again in a few month but for me it's a whole-weekend kind of deal and hardly a party drug

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#37
post #28
post #25

Earlier quoted context omitted.

Some people may also just be more sensitive to serotonergics, therefore it's simply easier for them to identify

But regardless of what enabled them to identify it - even if just a 50:50 guess, but a correct one - thinking they were on it (vs. thinking they were not) made it a significant enhancement? That seems like a 'bigger' result to me than what's claimed. (Which is why I'm not sure I'm understanding it correctly.)

You could see it that way. More intuitive to me though is that the ones who guessed correctly, had a stronger subjective effect, therefore were more successful in guessing. Does that make sense?

I hate these "two seemingly valid and contradictory ways of looking at it" things.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#38
post #6
post #3

(It's strange that we're using the term microdose, even in scientific contexts - prefixes have meanings - it should be called a decidose.) Anecdotally, I've had a degree of short term success treating my depression with smallish doses of mushrooms, but I've never had the continuing access required for a microdosing regiment. It'd be nice if the government were willing to come to the table on this, but alas. That said…

> It's strange that we're using the term microdose, even in scientific contexts - prefixes have meanings - it should be called a decidose. Not really - its from the Greek for small, rather than a SI prefix in this context. If the suffix were quantitative then you might have a case, but we talk quite happily about microphones and microscopes. Microdose is useful because it is not conditional on a particular regular do…

Also, 1 microbe is 1/1000000 of be.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#39

Earlier quoted context omitted.

Yeah, drugs feel great, news at 11. If psychiatry was just a matter of giving people a constant buzz, it would be solved a century ago. I'm not judging you for wanting to be high all the time, I've been there myself. But be intellectually honest and call it that, at least. Because it's not some kind of psychological panacea, and I wish people would stop implying it is. And yes, I've tried it. It made me high, but gen…

That's an uncharitable reading. OP is just sharing what works with her/him. Which is ok. From what I understood from your comment, for you it doesn't. Which is ok too, as now you know yourself a bit better. Two personal experiments with very different outcomes. There's no need for moral judgments either way.

I'm not saying her experience is invalid. If it works for her, great. But there is this tendency of microdosing proponents to oversell what is effectively a high(nothing wrong with that, I love getting high) as some sort of profound self-help tool. It's a high. That's fine. Getting high can have positive effects too. Call it that, though.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#40

Earlier quoted context omitted.

This is a common fallacy perpetuated by people who have only experienced the alcohol drug. Microdoses of psychedelics are not impairing. On the contrary, they can improve performance, especially in abstract problem solving.

This study doesn't bear that out, nor have any other placebo-controlled trials. Also, I've experienced about 40 different psychoactive drugs, including both micro and megadoses of psychedelics. And my experience tracks with GP in that it does cognitively impair you. Maybe don't make blanket statements about people you disagree with, it doesn't make your argument look any stronger.

This aligns with my experiences. Especially for me, how low my productivity was during the come down, which could sometimes last a week or four!
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