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We could have universal Covid vaccines soon

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Re: We could have universal Covid vaccines soon

#211

Earlier quoted context omitted.

What are those attitudes and behaviors, exactly?

Refusing to wear a mask indoors, attending large social gatherings sans mask, not getting vaccinated, and so on. It boils down to breathing into other people's faces a lot, which is what I call "exposure".

How long should be wear masks indoors and refuse to attend large indoor social gatherings? The rest of our lives?

Re: We could have universal Covid vaccines soon

#212
post #113

Earlier quoted context omitted.

So what's your plan then for groceries to magically appear in someone's house without driving or delivery? And if you say walk or bike or bus you clearly have very different shopping than I do - let me see you carry 2 cases of 15 bottles of seltzer, and a cart full of groceries on any of those.

When a supermarket is only a 10 minute walk away (20 minutes round trip), you just go more often and carry smaller amounts. Even if you suddenly needed 30 bottles of seltzer in the same day, you can just walk there and back twice.

If the supermarket is only 0.5 miles away, it's going to be quite small.

Normal sized supermarkets are in the range of 5 or so miles apart.

I am not interested in living in a place where tiny stores are my only option.

Also, why would I want to waste my time walking 20 minutes multiple times a week, plus time in the store? That sounds dreadful, why would you want that?

Re: We could have universal Covid vaccines soon

#213
well we already have this protein based vaccine Novavax 2373 with cross immune response based on prototype developed 2.5 years ago. because it not only has full representation of spike protein (unlike mRNA taking shortcut to represent S protein) but also cleavage site which is omicron BA5 immune escape from. However big pharma politics slowed down the approval, purpose delaying US P3 trial, introducing CMC requirement 1 month before formally submitting the application. Novavax 2373 has shown superb efficacy results since Jan 2021 UK trial and follow up study showed long term protection (titers half life 9months compared to mRNA 3months). no myocarditis risk. still FDA only approved it now half year after submission blaming the company's manufacture issue while it has been distributing hundred of millions of doses worldwide mRNA is not vaccine. it is only genetic therapy

Re: We could have universal Covid vaccines soon

#214

We could just approve Corbevax in the US. It's a more traditional vaccine and includes more of the virus than spike proteins. It's also unpatented and cheap. The cynic in me says there is huge interest in having an annual Covid vaccine like the flu one. They'll just change spike proteins every year in a never ending game of cat and mouse. With mRNA that game is easy and profitable.

Incorrect; according to Wikipedia, Corbevax just includes the receptor binding domain of the spike protein. It doesn't include other parts of the virus - were you confused by the adjuvants? Anyway, you might be interested in Novavax if you're looking for a nice, classic covid vaccine. It's not any more effective than the mRNA vaccines, but it's FDA-approved.

Novavax UK results on par with mRNA vaccine while trials conducted with variants alpha/beta already circulating. due to unbinding or cross over we cannot really measure long term protection. but several studies show 2373 is better but nobody knows it

Re: We could have universal Covid vaccines soon

#215

Earlier quoted context omitted.

Vaccines are not only supposed to benefit the recipient. Vaccination is a public health program . If vaccinating under fives reduces the risk to preschool carers and enables us to maintain higher preschool capacity then that's a public benefit that has nothing. to do with whether it affects the individual outcomes of five year olds who contract covid.

This gives me Omelas vibes. Is it really a good idea to increase risk of harm (via side effects) in our youngest for "the greater good"?

No post body was provided.

Re: We could have universal Covid vaccines soon

#216
post #86
post #4

> In the US, roughly as many vaccinated people in the US die from COVID every day as there are total deaths across the country in motor vehicle accidents. It's truly shocking that we're not doing more to reduce car dependency.

So here's what the pandemic should've made patently clear: people weigh up human lives against inconveniencce all the time. What is wearing a mask? it's an inconvenience. It clearly reduces transmission rates and would thus save lives but many don't want to be inconvenienced. Even taking the vaccine is merely on the level of inconvenience. After billions of dollars, the scaremongering horror stories about "side effec…

>After billions of dollars, the scaremongering horror stories about "side effects" and "long term effects" have of course never eventuated.

Never eventuated, like you mean Astrazeneca was never suspended in eighteen countries on three continents? and Nordics never suspended Moderna?

That never happened in your reality? Wild.

Re: We could have universal Covid vaccines soon

#217

Earlier quoted context omitted.

I had it, before a vaccine was available, and it was a nothing burger, like it was for most 30-somethings. If you already have natural immunity, or 1-2 doses of the vaccine, there’s no point worry about it.

I had the original strain and then delta 9 months later. I was 33-ish, decent BMI and I get more exercise than 99% of people. Both times I had two full weeks of extremely high fevers and I was the most fatigued I’ve ever been in my life, to the point where it was an incredible challenge to feed myself or go to the bathroom. The first time my around my lungs hurt enough where I could barely take a full breath and I de…

Am curious what blood test showed for antibodies after your first infection.

I had it 1.5 years ago. I just got another blood test and the IgG antibodies are still strong.

Re: We could have universal Covid vaccines soon

#218

Earlier quoted context omitted.

> Half the country demonized the other half of the country And also demonized Australia - "fascist"! "authoritarian"! - for being 6 months behind in COVID and still giving a shit when the USA already didn't. For us in Australia, early 2020 was 6 months of the USA looking like a disaster movie while almost noone had it here.

But did Australia's draconian lockdowns actually even accomplish anything other than delaying the inevitable? Hasn't COVID been going strong there since Christmas, despite everything they put their citizens through?

Pretty much, ripping through my city now. There isn't a lot of sentiment for liberty/freedoms here, so the authoritarians had a field day. We'll probably do it all again next time too.

Re: We could have universal Covid vaccines soon

#219

Earlier quoted context omitted.

> In dense cities like NY, I would say at least 20% of the city is infected right now. Workers. People on the street. The subway is disgusting, there is at least one infected person per carriage coughing over everyone and refusing to wear a mask. You walk around and hear that infected lung with light mucus cough. It’s everywhere. If you are to insult people's intelligence then don't use your own germophobic anecdotal…

Bob Wachter, who is the chair of medicine at UCSF periodically publishes the UCSF asymptomatic test positive rate. Everyone who is admitted to UCSF takes a Covid test. This rate is the fraction of people who are admitted without Covid symptoms, that test positive. IMO this is a very good number because it's a somewhat randomized population that is being tested in a controlled way, without too much bias. The latest nu…

And that’s asymptomatic! I caught 3 trains today, and in all of them someone was visibility sick and didn’t care. Someone was having a coughing fit on the platform, no mask of course. I went shopping, and several of the staff and shoppers were also visibility sick. One shopper started coughing in front of everyone and they completely ignored it and carried on. At a fast food restaurant (outdoors) there were at least 2 tables with people visibly sick eating their food.

Really, going out in public is quite a risk these days. The sheer number of infected all around you is quite troubling.

Re: We could have universal Covid vaccines soon

#220

We can't vaccinate our way out of this virus. Even without the issues of compliance, eradication is likely impossible with a respiratory virus like this. Even if you have a pan coronavirus nasal vaccine the NAbs will wane and people will get infected again. It doesn't matter if we use more mRNAs than just spike for more targets or anything else. It'll mutate, NAbs will wane, people won't get vaccinated and the virus…

> We can't vaccinate our way out of this virus...

because it transmits between humans and cats and deer.

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