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Modern city dwellers have lost about half their gut microbes

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Re: Modern city dwellers have lost about half their gut microbes

#111

Earlier quoted context omitted.

> People are becoming even lactose intolerant. This isn't new, and certainly isn't some crisis of the last 100 years. Historically only a minority of the planet has ever been lactase persistent into adulthood. It's a well-understood genetic trait, not some product of gut microbes.

You are correct. It's likely that the majority of humans have been lactose intolerant for human history. It's primarily people of Northern European descent that are not lactose intolerant, but lactose intolerance is very common outside of those groups

and west african; by two entirely separate mechanisms, which i’ve always found to be quite cool.

Re: Modern city dwellers have lost about half their gut microbes

#112

Earlier quoted context omitted.

Well, it's either a pill, or moving out of the city, or a fecal transplant (assuming that the urban / rural divide is relevant, and not just a proxy for diet). I don't live in the city, but if I were told that I would be healthier with more of these microbes that my environment doesn't support, I'd opt for the pill.

The study compares humans (who happen to live in cities) to primates (who definitely don't live in cities). It doesn't compare between human populations.

The content I replied to implied that the article was a submarine advertisement for pills.

If there is a problem in need of a solution, and it isn't diet related, I'd much prefer the pill over there other options.

Re: Modern city dwellers have lost about half their gut microbes

#113

Earlier quoted context omitted.

There's a guy (Jasper Lawrence, who had a horrible allergy problem) had heard of a study where they were testing to see if allergies was related to parasites. He was rejected from the study, so, long story short, he ended up flying to northern Africa and walking around barefoot to get hookworm. He now monitors and manages his hookworm infection with low doses of anti-parasite medication, and he sells soil infected wi…

Please, for the love of all that is good and holy, do not give yourself hookworms.

I get they are bad, but you seem to speak from experience, either yours or others. Out of curiosity, why not? What can happen?

Re: Modern city dwellers have lost about half their gut microbes

#114

Earlier quoted context omitted.

You are correct. It's likely that the majority of humans have been lactose intolerant for human history. It's primarily people of Northern European descent that are not lactose intolerant, but lactose intolerance is very common outside of those groups

and west african; by two entirely separate mechanisms, which i’ve always found to be quite cool.

> and west african; by two entirely separate mechanisms, which i’ve always found to be quite cool.

What's the separate mechanism? I'm only aware of one set of genes coding for adult lactase production.

Re: Modern city dwellers have lost about half their gut microbes

#115
post #45

Pretty much every culture around the world 100 years ago had some staple fermented food. Nowadays, a lot of people in western culture at least outright refuse yogurt or other fermented foods like saurkraut or pickled cabbage that used to be staples in these people's ancestor's diets a few generations ago. People are becoming even lactose intolerant. You have to fertilize your microbes so to speak and eat these sorts…

> You have to fertilize your microbes so to speak and eat these sorts of foods [citation needed]. It seems unlikely that fermented foods are not consumed in urban areas at all. I’ve also no idea if other primates consume any fermented foods, but I’d guess probably not. > People are becoming even lactose intolerant Do any other primates drink milk after infancy? If not, that’s not really a valid concern in the context…

The study is of US cities.

I would be curious to see if you took, say, South Korean cities, what the results would be. (Seoul is one of the largest megacities in the world, and kimchi is an extremely common fermented food.)

Re: Modern city dwellers have lost about half their gut microbes

#116
post #20

Does anyone know of probiotics with a variety of bacteria? Currently they (and yoghurts) seem to be just a single type, which doesn't make a lot of sense to me. If there are unusual bacteria out there where do they come from and how can we get them? I've done a bunch of anti-biotics in the last few years so what to get back to what I was.

"Does anyone know of probiotics with a variety of bacteria?"

Home fermenting and raw products (honey, fruit, veggies, etc) are probably a good place for variety. You may have a primary strain you're fermenting with, but there are likely other minority strains present too.

Re: Modern city dwellers have lost about half their gut microbes

#117

I think the consensus is nobody really knows and nutritional science is largely trendy pseudoscience…

I've always been shocked at how crappy the research into nutrition is and how there's very little consensus beyond "vegetables are good" and how shoddy a lot of the professional training is for dieticians. Nearly everybody eats nearly every day, how have we not figured this out?

Everyone wants to be the one eating - no one wants to be the foodless researcher.

Re: Modern city dwellers have lost about half their gut microbes

#118
post #99

Earlier quoted context omitted.

> People are becoming even lactose intolerant. This isn't new, and certainly isn't some crisis of the last 100 years. Historically only a minority of the planet has ever been lactase persistent into adulthood. It's a well-understood genetic trait, not some product of gut microbes.

You can think of this being evolutionary beneficial, if some milk is bad, the whole village don't all get sick. Also a possible reason for why people have different taste preferences.

It seems that lactose tolerance is the new thing here.

Lactose intolerance is normal, but for a few people, presumably dairy animal farmers, something happened to their genes and they became tolerant, and it was an evolutionary avantage because they had access to all that milk. But because access to farmed milk is relatively recent from an evolutionary standpoint and people can live with lactose intolerance, the trait hasn't spread to all of humanity.

Re: Modern city dwellers have lost about half their gut microbes

#119
post #99

Earlier quoted context omitted.

> People are becoming even lactose intolerant. This isn't new, and certainly isn't some crisis of the last 100 years. Historically only a minority of the planet has ever been lactase persistent into adulthood. It's a well-understood genetic trait, not some product of gut microbes.

You can think of this being evolutionary beneficial, if some milk is bad, the whole village don't all get sick. Also a possible reason for why people have different taste preferences.

What does lactose tolerance have to do with "bad" milk?

Re: Modern city dwellers have lost about half their gut microbes

#120

Earlier quoted context omitted.

Eating yogurt or sauerkraut will not render you (once again) lactose tolerant. Lactase (the enzyme that breaks down lactose) production is regulated by a human gene; how would a probiotic like yogurt alter a gene? https://biologydictionary.net/lactase/

Epigenetic reversal of some inhibitory histone marks at the promoter region of the enzyme? Driven by some yet-to-be-discovered signaling cascade induced by reintroduction of lactose and proliferation of lactose loving microbes? Just spitballing, this is pure speculation, but is plausible.

I have noticed pseudosciences are becoming fashionable again.
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