111–120 of 216 posts
The problem is that you have to take them often to colonize your gut, so it becomes a bit expensive, and it won't work on everyone, depending on their gut (since scientists know too little about the gut).
I haven't studied this topic however.
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Definitely going to try this too. I go though periods of acid reflux and it wakes me up. I sleep with 2 pillows so raise my head and shoulders to prevent it waking me which helps most of the time. But will give the probiotics a try. Thanks.
Curious - are you a back sleeper? (Or what type of sleeper are you?)
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The community has grown a lot. A ton of junk is posted (a ton, browse new for a while) but the real deal here is that sometimes enough people upvote the junk to frontpage it. I don't know why but I think sometimes some people just want certain things to be true.
I'm speaking from anecdotal evidence here but I have seen a lot of research that indicate the digestive tract is basically the primary storage of serotonin. And whenever I get chronically depressed I also get chronically constipated. I don't necessarily think probiotics are a magical cure but I think anything that aids with digestion and moving things through the digestive tract can help.
Gut motility is driven by the autonomic nervous system. The sympathetic nervous system controls colon motility, and the parasympathetic controls digestion and stomach emptying. Depending on the type of depression you have, it can alter the HPA axis up or down. Let's say you have the "don't want to get out of bed and do anything" type. In that case your HPA axis is likely underactive. That results in reduced sympathetic nervous system activation (as it operates in parallel with the HPA axis). That then results in reduced colon motility and constipation.
Sometimes often I get constipation at weekends for this reason. I'm not depressed, but if I don't do much at the weekend after a busy week then (I assume) my HPA axis reduces, and that causes constipation.
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Are you sure you don't have sleep apnea? I did... or rather I do, but if I sleep with a CPAP machine, I wake up with a feeling like you describe. I hate that machine, but it works.
I'm pretty sure I don't. I suppose I could try one out or get a test.
Incidentally I had it and never knew about it until I had the sleep study. I never woke up gasping for breath or anything like that.
https://forbetterscience.com/2022/06/17/schneider-shorts-17-...
Sample size of 1 here, but just hear me out. Probiotics are a cheap and low-risk. If you have any general inflammation type issues that don't seem to have a cause, it might be worthwhile to just try probiotics. My Dr. told me to try them for a digestive issue - and they sort of helped that. But a handful of other things unexpectedly improved. Acid reflux went from really bad to barely noticeable, and my skin really c…
What's the brand/dosage you use? There's so many different brands out there.
I take one every other day.
Full paper here: https://www.nature.com/articles/s41398-022-01977-z Skip down to Figure 1 to see the chart. Note that the response to placebo is normally extremely strong in depression studies, so it’s normal to see both groups improve drastically like this. The only thing that jumps out to me is that the probiotic group started with HAM-D depression inventory scores that were notably higher. When measuring absolute…
HN users seem to have a habit of posting crap science wrapped up in impressive sounding news stories, and it's kind of annoying. This is meant to be a group of intelligent people who should have the ability to click on the link to the article and look at the actual results.
I don't have a blood glucose problem particularly, but I am hoping to reduce inflammation. The manufacturer offers several probiotic supplements, and Sugar Shift seems to be the most comprehensive.
[0] https://biotiquest.com/pages/sugar-shift [1] https://biotiquest.com/blogs/blog/sugar-shift-challenge-the-... [2] https://drdavisinfinitehealth.com/
Sample size of 1 here, but just hear me out. Probiotics are a cheap and low-risk. If you have any general inflammation type issues that don't seem to have a cause, it might be worthwhile to just try probiotics. My Dr. told me to try them for a digestive issue - and they sort of helped that. But a handful of other things unexpectedly improved. Acid reflux went from really bad to barely noticeable, and my skin really c…
Quoting directly from [1] "Effect of Probiotic Use on Antibiotic Administration Among Care Home Residents: A Randomized Clinical Trial"
"...participants who were randomized to the probiotic group were administered significantly more antibiotics for lower respiratory tract infections, had small but statistically significant lower self-reported generic well-being/capability scores at 3 months, and a prespecified sensitivity analysis found a significant increase in cumulative systemic antibiotic days.
These findings should be interpreted with caution, given multiple testing. However, this study does not rule out harm from probiotics. Certain probiotics may delay the return of the host gut microbiome to its normal state after antibiotic treatment,[2] and a retrospective single-center study found probiotic exposure was associated with C difficile infection in hospitalized patients.[3]"
[1] Butler CC, Lau M, Gillespie D, et al. Effect of Probiotic Use on Antibiotic Administration Among Care Home Residents: A Randomized Clinical Trial. JAMA. 2020;324(1):47–56. doi:10.1001/jama.2020.8556
[2] Suez J , Zmora N , Zilberman-Schapira G , et al Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT. Cell. 2018;174(6):1406-1423.e1416. doi:10.1016/j.cell.2018.08.047
[3] Carvour ML , Wilder SL , Ryan KL , et al. Predictors of Clostridium difficile infection and predictive impact of probiotic use in a diverse hospital-wide cohort. Am J Infect Control. 2019;47(1):2-8. doi:10.1016/j.ajic.2018.07.014