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Probiotics can support the effect of antidepressants

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Re: Probiotics can support the effect of antidepressants

#61

Post by SaintGhurka »

pcarolan wrote: post #52
SaintGhurka wrote: post #21

Sample size of 1 here, but just hear me out. Probiotics are a cheap and low-risk. If you have any general inflammation type issues that don't seem to have a cause, it might be worthwhile to just try probiotics. My Dr. told me to try them for a digestive issue - and they sort of helped that. But a handful of other things unexpectedly improved. Acid reflux went from really bad to barely noticeable, and my skin really c…

Can you recommend at good product at that price point?

The only one I've ever taken is "Culturelle Digestive Daily Probiotic". It comes to $0.50 per pill. There are much cheaper generics but I haven't had the guts (no pun intended) to switch away from what's working to try them.

Re: Probiotics can support the effect of antidepressants

#62

Post by cpncrunch »

PragmaticPulp wrote: post #41

Full paper here: https://www.nature.com/articles/s41398-022-01977-z Skip down to Figure 1 to see the chart. Note that the response to placebo is normally extremely strong in depression studies, so it’s normal to see both groups improve drastically like this. The only thing that jumps out to me is that the probiotic group started with HAM-D depression inventory scores that were notably higher. When measuring absolute…

HN users seem to have a habit of posting crap science wrapped up in impressive sounding news stories, and it's kind of annoying. This is meant to be a group of intelligent people who should have the ability to click on the link to the article and look at the actual results.

Re: Probiotics can support the effect of antidepressants

#63

Post by [deleted] »

PragmaticPulp wrote: post #41

Full paper here: https://www.nature.com/articles/s41398-022-01977-z Skip down to Figure 1 to see the chart. Note that the response to placebo is normally extremely strong in depression studies, so it’s normal to see both groups improve drastically like this. The only thing that jumps out to me is that the probiotic group started with HAM-D depression inventory scores that were notably higher. When measuring absolute…

[deleted]

Re: Probiotics can support the effect of antidepressants

#64

Post by SaintGhurka »

chasebank wrote: post #53
SaintGhurka wrote: post #21

Sample size of 1 here, but just hear me out. Probiotics are a cheap and low-risk. If you have any general inflammation type issues that don't seem to have a cause, it might be worthwhile to just try probiotics. My Dr. told me to try them for a digestive issue - and they sort of helped that. But a handful of other things unexpectedly improved. Acid reflux went from really bad to barely noticeable, and my skin really c…

I have a sample size of 1 as well. Probiotics didn’t help me but I’ve dealt with digestive issues for the last 4 years after a bout of food poisoning. I used to think gut flora / microbiome was quackery but I recently did an oral FMT (fecal microbiata transplant) the results were unreal. For reference, I’m a 37 y/o fit male and donor was 18 y/o female. After 2nd week I got the deepest sleep since I was a child (slept…

Are you sure you don't have sleep apnea? I did... or rather I do, but if I sleep with a CPAP machine, I wake up with a feeling like you describe.

I hate that machine, but it works.

Re: Probiotics can support the effect of antidepressants

#65

Post by guerrilla »

cpncrunch wrote: post #62
PragmaticPulp wrote: post #41

Full paper here: https://www.nature.com/articles/s41398-022-01977-z Skip down to Figure 1 to see the chart. Note that the response to placebo is normally extremely strong in depression studies, so it’s normal to see both groups improve drastically like this. The only thing that jumps out to me is that the probiotic group started with HAM-D depression inventory scores that were notably higher. When measuring absolute…

HN users seem to have a habit of posting crap science wrapped up in impressive sounding news stories, and it's kind of annoying. This is meant to be a group of intelligent people who should have the ability to click on the link to the article and look at the actual results.

The community has grown a lot. A ton of junk is posted (a ton, browse new for a while) but the real deal here is that sometimes enough people upvote the junk to frontpage it. I don't know why but I think sometimes some people just want certain things to be true.

Re: Probiotics can support the effect of antidepressants

#66

Post by SaintGhurka »

philliphaydon wrote: post #60
SaintGhurka wrote: post #38

Earlier quoted context omitted.

Culturelle. Just their basic "Digestive Daily Probiotic". It's a single strain Lactobacillus rhamnosus. My Dr. suggested either that or Align. The first thing I tried worked so I haven't tried anything else. A friend of mine had the same problem and he buys generic bulk acidophilus from amazon and he says it works for him. I didn't expect it to work, but I didn't want to wonder if it failed because I cheaped out, so…

Definitely going to try this too. I go though periods of acid reflux and it wakes me up. I sleep with 2 pillows so raise my head and shoulders to prevent it waking me which helps most of the time. But will give the probiotics a try. Thanks.

Good luck. I hope it works for you.

Re: Probiotics can support the effect of antidepressants

#67

Post by enviclash »

PragmaticPulp wrote: post #41

Full paper here: https://www.nature.com/articles/s41398-022-01977-z Skip down to Figure 1 to see the chart. Note that the response to placebo is normally extremely strong in depression studies, so it’s normal to see both groups improve drastically like this. The only thing that jumps out to me is that the probiotic group started with HAM-D depression inventory scores that were notably higher. When measuring absolute…

Very good insights. Still I am surprised by one point: why do you use the verb "afford" for probiotics? Kefir from milk is home-made and 1.5 buck per liter at most.

Re: Probiotics can support the effect of antidepressants

#68

Post by [deleted] »

MezzoDelCammin wrote: post #18
mrfusion wrote: post #12

How to find the best probiotics?

The original study [1] uses Vivomixx in about double dose. According to them it's because it is easily accessible and has multiple strains of bacteria in it (they were not trying to go for one strain in particular). 1 : chapter "Study intervention" of https://www.nature.com/articles/s41398-022-01977-z

[deleted]

Re: Probiotics can support the effect of antidepressants

#69

Post by Mountain_Skies »

loufe wrote: post #59
chasebank wrote: post #53

Earlier quoted context omitted.

I have a sample size of 1 as well. Probiotics didn’t help me but I’ve dealt with digestive issues for the last 4 years after a bout of food poisoning. I used to think gut flora / microbiome was quackery but I recently did an oral FMT (fecal microbiata transplant) the results were unreal. For reference, I’m a 37 y/o fit male and donor was 18 y/o female. After 2nd week I got the deepest sleep since I was a child (slept…

This was a fascinating read, thank you for sharing. Were there really no lasting effects? I'm curious why the introduced bacteria didn't flourish and permanently change your microbiome. Can anybody weigh in?

It might be that they have to hit a certain critical mass to become self-sustaining. Or they require a particular environment to thrive, which exists in the donor but not in the donee. It's such a new field, at least for prescriptive medicine, that it'll probably be a while before we get a good base of understand of what lives in our gut, what it does, and how to keep it healthy.

Re: Probiotics can support the effect of antidepressants

#70

Post by pionar »

vecter wrote: post #32
ianstormtaylor wrote: post #24

Anyone have recommendations for which probiotics are the best ones to buy? I always get confused while looking at all the various options, and this seems like a good place to find someone who’s done a lot of research.

I've had bad gas most of my life. I just kind of assumed it was me and there was nothing I could do about it. I started on 10 Billion CFUs of Lactobacillus Acidophilus [0] a few weeks ago and my gas went away in literally one day. I take 10B CFUs every day or every other day now (every other is probably sufficient), and it's still gone. I'm literally amazed. I started taking it because I saw a video from Dr. Eric Ber…

It should be noted that Eric Berg is a known quack and conspiracy theorist. I'd be careful taking what he says as fact.

He is not a medical doctor, he is a chiropractor.

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