n=40, seems a bit small. But this fits into a lot of anecdotal accounts I've heard. Gut flora is very complex and not well understood.
What is an adequate sample size depends entirely on the effect size.
Probiotics can support the effect of antidepressants
51–60 of 216 posts
Re: Probiotics can support the effect of antidepressants
#52Sample size of 1 here, but just hear me out. Probiotics are a cheap and low-risk. If you have any general inflammation type issues that don't seem to have a cause, it might be worthwhile to just try probiotics. My Dr. told me to try them for a digestive issue - and they sort of helped that. But a handful of other things unexpectedly improved. Acid reflux went from really bad to barely noticeable, and my skin really c…
Can you recommend at good product at that price point?
Re: Probiotics can support the effect of antidepressants
#53Sample size of 1 here, but just hear me out. Probiotics are a cheap and low-risk. If you have any general inflammation type issues that don't seem to have a cause, it might be worthwhile to just try probiotics. My Dr. told me to try them for a digestive issue - and they sort of helped that. But a handful of other things unexpectedly improved. Acid reflux went from really bad to barely noticeable, and my skin really c…
I have a sample size of 1 as well. Probiotics didn’t help me but I’ve dealt with digestive issues for the last 4 years after a bout of food poisoning. I used to think gut flora / microbiome was quackery but I recently did an oral FMT (fecal microbiata transplant) the results were unreal.
For reference, I’m a 37 y/o fit male and donor was 18 y/o female. After 2nd week I got the deepest sleep since I was a child (slept for 11 hours straight - went to bed, teleported to the morning) and woke up with this hard to describe feeling. I literally felt like I was 16 again. This sort of optimism / happiness I hadn’t felt in years. And I’m a generally happy dude! All my symptoms went away and the euphoric feeling persisted. Whatever the bacteria did was truly remarkable. The bad news is a few weeks after the FMT was finished, things went back to the way they were before. I’d continue to do them forever but it was very expensive, $1400 for the month. Fwiw, I tried it again with another donor with zero results so I could have been a fluke.
I do think I’ll try it again with the original donor. It was a spectacular month. I really think the microbiome is a major key to our health and wellness. Remember the blood boy from Silicon Valley? I bet we see ‘fecal boys’ for rich people in the near future.
If you’re interested, I’ll link the source and study I based my dosage off below. The guy who runs the fmt operation very passionate about the concept.
Re: Probiotics can support the effect of antidepressants
#54Anyone have recommendations for which probiotics are the best ones to buy? I always get confused while looking at all the various options, and this seems like a good place to find someone who’s done a lot of research.
I think the market is flooded with supplements, while you can help your gut bacteria with natural products like kefir (kind of buttermilk), kombucha, kimchi like products. I happen to love all those mentioned.
Those are all very bad recommendations. Buttermilk is loaded with cholesterol and saturated fat, kombucha with sugar, and fermented vegetables like kimchi have shown to increase prostate adenocarcinoma. You want to regulate your gut flora with a variety of whole plant-based foods, not quick fixes like pills and a jar of stinky cabbage.
Re: Probiotics can support the effect of antidepressants
#55> Probiotics maintained microbial diversity and increased the abundance of the genus Lactobacillus, indicating the effectivity of the probiotics to increase specific taxa. The increase of the Lactobacillus was associated with decreased depressive symptoms in the probiotics group. [0] So, yogurt everybody ? [1] [2] [0] https://www.nature.com/articles/s41398-022-01977-z [1] https://en.wikipedia.org/wiki/Yogurt#Health_r…
As long as it's not cow's milk yogurt, sure.
https://pubmed.ncbi.nlm.nih.gov/20389060/
https://pubmed.ncbi.nlm.nih.gov/23415826/
Also, the citations in the wikipedia article are hilariously biased.
> Presented at the satellite symposium “First Global Summit on the Health Effects of Yogurt." The conference was organized by the ASN, the Nutrition Society, Danone Institute International, and the Dairy Research Institute
Another paper was straight up one paid consultant writing an industry-funded article. Here's who edited and reviewed it:
> Editorial assistance was provided by Chill Pill Media LLP, which was contracted and funded by Danone Institute International.
It's hilarious how desperate the dairy industry is to cook science.
Re: Probiotics can support the effect of antidepressants
#56[deleted]
Re: Probiotics can support the effect of antidepressants
#57Sample size of 1 here, but just hear me out. Probiotics are a cheap and low-risk. If you have any general inflammation type issues that don't seem to have a cause, it might be worthwhile to just try probiotics. My Dr. told me to try them for a digestive issue - and they sort of helped that. But a handful of other things unexpectedly improved. Acid reflux went from really bad to barely noticeable, and my skin really c…
I have a sample size of 1 as well. Probiotics didn’t help me but I’ve dealt with digestive issues for the last 4 years after a bout of food poisoning. I used to think gut flora / microbiome was quackery but I recently did an oral FMT (fecal microbiata transplant) the results were unreal. For reference, I’m a 37 y/o fit male and donor was 18 y/o female. After 2nd week I got the deepest sleep since I was a child (slept…
Thank you for that. I've wondered if those transplants stick.
Hopefully this becomes an area of major research because all the anecdotes sound so promising.
Re: Probiotics can support the effect of antidepressants
#58Sample size of 1 here, but just hear me out. Probiotics are a cheap and low-risk. If you have any general inflammation type issues that don't seem to have a cause, it might be worthwhile to just try probiotics. My Dr. told me to try them for a digestive issue - and they sort of helped that. But a handful of other things unexpectedly improved. Acid reflux went from really bad to barely noticeable, and my skin really c…
> Probiotics are a cheap and risk-free. Not entirely risk-free, but the side effects of a negative reaction don’t last too long at least. I felt notably worse for about a week after trying one of the mainstream probiotic brands with strange brain fog I couldn’t shake. This effect was repeatable and I could start the malaise again by resuming the probiotic. The same effect didn’t happen with another antibiotic with di…
I believe it's not risk-free. For example, I read that immuno-suppressed people should avoid consuming kombucha, kefir, etc.
Re: Probiotics can support the effect of antidepressants
#59Sample size of 1 here, but just hear me out. Probiotics are a cheap and low-risk. If you have any general inflammation type issues that don't seem to have a cause, it might be worthwhile to just try probiotics. My Dr. told me to try them for a digestive issue - and they sort of helped that. But a handful of other things unexpectedly improved. Acid reflux went from really bad to barely noticeable, and my skin really c…
I have a sample size of 1 as well. Probiotics didn’t help me but I’ve dealt with digestive issues for the last 4 years after a bout of food poisoning. I used to think gut flora / microbiome was quackery but I recently did an oral FMT (fecal microbiata transplant) the results were unreal. For reference, I’m a 37 y/o fit male and donor was 18 y/o female. After 2nd week I got the deepest sleep since I was a child (slept…
This was a fascinating read, thank you for sharing. Were there really no lasting effects? I'm curious why the introduced bacteria didn't flourish and permanently change your microbiome. Can anybody weigh in?
Re: Probiotics can support the effect of antidepressants
#60Earlier quoted context omitted.
> But a handful of other things unexpectedly improved. Acid reflux went from really bad to barely noticeable What are you even buying if you don't mind me asking? I don't get acid reflux often, but I definitely want to prevent it happening so often, because it continues for days when I do get it. There's all sorts of things that say they have / are probiotics, including a few different sodas out there.
Culturelle. Just their basic "Digestive Daily Probiotic". It's a single strain Lactobacillus rhamnosus. My Dr. suggested either that or Align. The first thing I tried worked so I haven't tried anything else. A friend of mine had the same problem and he buys generic bulk acidophilus from amazon and he says it works for him. I didn't expect it to work, but I didn't want to wonder if it failed because I cheaped out, so…
Definitely going to try this too. I go though periods of acid reflux and it wakes me up. I sleep with 2 pillows so raise my head and shoulders to prevent it waking me which helps most of the time. But will give the probiotics a try. Thanks.