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Mammals can breathe through their intestines (2021)

science.org

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Re: Mammals can breathe through their intestines (2021)

#121

Post by krageon »

virgildotcodes wrote: post #115

> To find out, Takanori Takebe, a gastroenterologist from Cincinnati Children's Hospital, and his colleagues tested several approaches to ventilating the intestines of mice and pigs that were deprived briefly of oxygen. In one group of 11 mice, four had their intestines scrubbed to thin the mucosal lining and improve oxygen absorption. Next, the researchers injected pure, pressurized oxygen into the rectums of the sc…

Some ethics board out there looked at this proposal and thought "well, that looks fine to me!". That thought is almost as horrifying as the torture these scientists visited upon these defenseless mice.

Re: Mammals can breathe through their intestines (2021)

#122

Post by micromacrofoot »

virgildotcodes wrote: post #115

> To find out, Takanori Takebe, a gastroenterologist from Cincinnati Children's Hospital, and his colleagues tested several approaches to ventilating the intestines of mice and pigs that were deprived briefly of oxygen. In one group of 11 mice, four had their intestines scrubbed to thin the mucosal lining and improve oxygen absorption. Next, the researchers injected pure, pressurized oxygen into the rectums of the sc…

Yeah not sure the ends justify the means here, that's for sure.

Re: Mammals can breathe through their intestines (2021)

#123

Post by Psyladine »

virgildotcodes wrote: post #115

> To find out, Takanori Takebe, a gastroenterologist from Cincinnati Children's Hospital, and his colleagues tested several approaches to ventilating the intestines of mice and pigs that were deprived briefly of oxygen. In one group of 11 mice, four had their intestines scrubbed to thin the mucosal lining and improve oxygen absorption. Next, the researchers injected pure, pressurized oxygen into the rectums of the sc…

If you don't want to know how the sausage is made, mate...you may think different if you will end up laid up with non-functioning lungs and only this niche medical apparatus available.

Re: Mammals can breathe through their intestines (2021)

#124

Post by thirtyfivecent »

virgildotcodes wrote: post #115

> To find out, Takanori Takebe, a gastroenterologist from Cincinnati Children's Hospital, and his colleagues tested several approaches to ventilating the intestines of mice and pigs that were deprived briefly of oxygen. In one group of 11 mice, four had their intestines scrubbed to thin the mucosal lining and improve oxygen absorption. Next, the researchers injected pure, pressurized oxygen into the rectums of the sc…

No post body was provided.

Re: Mammals can breathe through their intestines (2021)

#125

Post by jamal-kumar »

virgildotcodes wrote: post #115

> To find out, Takanori Takebe, a gastroenterologist from Cincinnati Children's Hospital, and his colleagues tested several approaches to ventilating the intestines of mice and pigs that were deprived briefly of oxygen. In one group of 11 mice, four had their intestines scrubbed to thin the mucosal lining and improve oxygen absorption. Next, the researchers injected pure, pressurized oxygen into the rectums of the sc…

What ever works in a bio lab before? There are devices that are made to turn live mice into a fine slurry to study their contents

Re: Mammals can breathe through their intestines (2021)

#126

Post by niemandhier »

micromacrofoot wrote: post #122
virgildotcodes wrote: post #115

> To find out, Takanori Takebe, a gastroenterologist from Cincinnati Children's Hospital, and his colleagues tested several approaches to ventilating the intestines of mice and pigs that were deprived briefly of oxygen. In one group of 11 mice, four had their intestines scrubbed to thin the mucosal lining and improve oxygen absorption. Next, the researchers injected pure, pressurized oxygen into the rectums of the sc…

Yeah not sure the ends justify the means here, that's for sure.

They do. If this can be extended to humans, the resulting technology would have saved hundreds of lives during Covid alone, not to think of burn victims.

Re: Mammals can breathe through their intestines (2021)

#127

Post by belorn »

dandare wrote: post #97

Anybody else concerned about the ethics of scrubbing intestines, injecting gas into intestines, then suffocation the mammals to death? Are animals in these procedures routinely anaesthetised?

Animal trials usually involve a ethics committee. The big problem is that outside of mathematical/computer experiments, it is almost impossible to do medical testing in an ethical way. With exception to experiments done on brain dead (which still involve some measure of uncertainty), on who or what should test be conducted on. In the past we used war criminals or criminals sentenced to death, but that has an obviously ethically problem. We could use military recruits that volunteers, or poor people who would volunteer in exchange for monetary compensation, but how well understand is the consent and how ethical is it use people like that? We could use patients who are out of options, but how ethical is it to exploit people who has no realistic choices?

It is hard to view animal testing as anything else than cruelty to animals. I can only hope that it was there was no other options, and that they indeed got anaesthetised.

(Someone here mentioned experiments in breathing in oxygen-rich perfluorocarbons that used navy recruits. I have seen discussions about how much those consent should actually count considering the power balance and hierarchical culture that exist in the military).

Re: Mammals can breathe through their intestines (2021)

#128

Post by jensenbox »

Traubenfuchs wrote: post #40
jensenbox wrote: post #28

Earlier quoted context omitted.

I had the exact same though - this could make the suits a reality - providing that the traveller does not need to take large doses of morphine to deal with the pain or are dosed with amyl nitrite. I bet you would be "gassy" for weeks on end - with a dangerous combination of both pure oxygen and methane - sounds like a party to me.

Liquid breathing hurts?

The article is not referring to using your lungs to breath...

I can only imagine they way they are indicating the administration of the oxygen would be painful.

Re: Mammals can breathe through their intestines (2021)

#129

Post by LinuxBender »

0des wrote: post #8
mbrundle wrote: post #2

This reminds me of the scene in The Abyss where the rat is forced to breathe in oxygen-rich perfluorocarbons[1]. I think this idea of introducing oxygen through perfluorocarbons has been explored but not sure it’s made much headway in humans to date [2]. This paper seems like a clever idea to introduce the liquid anally where oxygen can diffuse through the linings, and to also use same liquid (because of its viscosit…

I wonder what effects emerge from chronically removing intestinal mucosa

I've done it. Inflammation, sensitivity to bacterium, gut pain. The mucus regenerates but takes some time. I found that in my case diet cranberry juice and mastic gum helped until the mucus regenerated.

Some people with severe IBS get to experience this often. I am thankful to not be one of them.

Re: Mammals can breathe through their intestines (2021)

#130

Post by kayodelycaon »

Traubenfuchs wrote: post #40
jensenbox wrote: post #28

Earlier quoted context omitted.

I had the exact same though - this could make the suits a reality - providing that the traveller does not need to take large doses of morphine to deal with the pain or are dosed with amyl nitrite. I bet you would be "gassy" for weeks on end - with a dangerous combination of both pure oxygen and methane - sounds like a party to me.

Liquid breathing hurts?

Having gas pumped into you intestines is quite unpleasant. (Woke up mid-colonoscopy, not fun.)
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