If wealth disparity continues to increase these treatments will likely be unavailable to average people. Get rich or support economic policies that prevent oligarchs and billionaires.
Ask HN: What can I do today to prepare for anti-aging tech of the future?
31–40 of 52 posts
Re: Ask HN: What can I do today to prepare for anti-aging tech of the future?
#32Earlier quoted context omitted.
Having children or grandchildren is even more of a reason to be interested in research that prevents the diseases of aging (longevity). When you get the diseases of aging that precede death, like Alzheimer’s or cancer or heart disease or just simply becoming frail, your children and grandchildren suffer greatly. What is narcissistic about not wanting your children and grandchildren to watch you suffer one or more of…
The history of extending human life through sanitation, disease prevention (vaccines and antibiotics), and treatment for chronic conditions has so far led to even worse conditions brought on by age. Centuries ago almost no one lived long enough to die from heart disease, cancer, or dementia. Now those are common, diseases of old age, imposing tremendous costs. I don’t propose going back to 35 year lifespans or some k…
I think that’s the big difference between how medicine up until now has approached aging and how longevity research approaches aging. Longevity research is about preventing the state that causes people to get those diseases of aging in the first place, not trying to find bandaids once people are already sick. Can’t imagine how preventing Alzheimer’s, cancer, and heart disease could be a bad thing.
Re: Ask HN: What can I do today to prepare for anti-aging tech of the future?
#33The NIH Interventions Testing Program has identified 6 compounds that significantly extend HEALTHY life (in model animals). Some of these compounds have been tested in multiple model animals and the effect is conserved across all of them. Human trials are expensive and obviously take multiple decades, so you’ll be dead before to see that data. The compounds so far are: rapamycin, acarbose, 17-alpha-estradiol, canagli…
So where does one ingest these?
Astaxanthin is a relatively safe, readily available supplement.
For the rest of those, you really would want to be under the supervision of a doctor.
https://www.rapamycin.news/t/doctors-who-prescribe-rapamycin...
Re: Ask HN: What can I do today to prepare for anti-aging tech of the future?
#34Re: Ask HN: What can I do today to prepare for anti-aging tech of the future?
#35Avoid accidents that could trivially kill you. Cycling and motorcycles are ones people underestimate the danger of.
Re: Ask HN: What can I do today to prepare for anti-aging tech of the future?
#36IIRC the longest living people kept doing physical activity. So I second that.
Also having good relations with people around you can take you miles.
Re: Ask HN: What can I do today to prepare for anti-aging tech of the future?
#37Earlier quoted context omitted.
Having children or grandchildren is even more of a reason to be interested in research that prevents the diseases of aging (longevity). When you get the diseases of aging that precede death, like Alzheimer’s or cancer or heart disease or just simply becoming frail, your children and grandchildren suffer greatly. What is narcissistic about not wanting your children and grandchildren to watch you suffer one or more of…
The history of extending human life through sanitation, disease prevention (vaccines and antibiotics), and treatment for chronic conditions has so far led to even worse conditions brought on by age. Centuries ago almost no one lived long enough to die from heart disease, cancer, or dementia. Now those are common, diseases of old age, imposing tremendous costs. I don’t propose going back to 35 year lifespans or some k…
> Centuries ago almost no one lived long enough to die from heart disease, cancer, or dementia.
Right, they were dying of infections, starvation, childbirth and cholera, appendicitis and anthrax, typhoid and typhus, polio and tetanus. Are you saying that those were better?
Re: Ask HN: What can I do today to prepare for anti-aging tech of the future?
#38Among the most promising anti-aging drugs is metformin. Type 2 diabetics on metformin live 15% longer than non-diabetics. This is remarkable considering how big a health disadvantage diabetes itself is. Metformin seems to mimic fasting somehow, by interfering with mitochondrial function. For more information I refer you to David Sinclair's numerous discussions on this topic. He takes 1 gram of metformin per day with…
Seems like simply fasting should yeild the same results without the side effects. Any reason not to recommend fasting then?
It seems to mimic exercise, too. Not just fasting.
Metformin has numerous other effects: it reduces carbohydrate absorption in the gut, changes the gut microbiome, increases insulin sensitivity, reduces the liver's conversion of proteins to glucose, changes the way proteins accumulate in the brain (thereby making dementia less likely), etc.
When you're on metformin you can feel the physiological stress. It's like a mild attack on your whole body, a persistent slight discomfort. It's like a very mild poison.
Re: Ask HN: What can I do today to prepare for anti-aging tech of the future?
#39If wealth disparity continues to increase these treatments will likely be unavailable to average people. Get rich or support economic policies that prevent oligarchs and billionaires.
Nope, I dont agree, if this kind of cancellation was a motive our progress in academic research should already slowed down.
Re: Ask HN: What can I do today to prepare for anti-aging tech of the future?
#40The NIH Interventions Testing Program has identified 6 compounds that significantly extend HEALTHY life (in model animals). Some of these compounds have been tested in multiple model animals and the effect is conserved across all of them. Human trials are expensive and obviously take multiple decades, so you’ll be dead before to see that data. The compounds so far are: rapamycin, acarbose, 17-alpha-estradiol, canagli…
> meclizine
The anti-nausea drug?